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公开(公告)号：KR790000101B1
公开(公告)日：1979-03-15
申请号：KR740001508
申请日：1974-02-15
Applicant: FUJISAWA PHARMACEUTICAL CO
Inventor： HASHIMETO MASASHI , KAMIYA TAKASHI , TERACHI TSUDOMU
Abstract: The penams(I) and cephams(II) (e.g. R =PhCH2, PhOCH2, 2-thienylmethyl, protected phCHNH2; R1 = CH2CCl3, Me; R2 = Cl, Br, OAc, OMe, SCN), useful as antimicrobial agent, were prepd. by cyclizing(III) with a suitable reagent for providing R2. III was prepd. by reaction of thiol compound and 2-methyl-2-lower alkyl-6-substituted penam-3-carboxylicacid-1-oxide. Subsequent reaction of I and II included deacylation, ester hydrolysis, S-oxidn. and substitution at R2..
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