公开(公告)号：KR790000101B1

公开(公告)日：1979-03-15

申请号：KR740001508

申请日：1974-02-15

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： HASHIMETO MASASHI ,  KAMIYA TAKASHI ,  TERACHI TSUDOMU

Abstract: The penams(I) and cephams(II) (e.g. R =PhCH2, PhOCH2, 2-thienylmethyl, protected phCHNH2; R1 = CH2CCl3, Me; R2 = Cl, Br, OAc, OMe, SCN), useful as antimicrobial agent, were prepd. by cyclizing(III) with a suitable reagent for providing R2. III was prepd. by reaction of thiol compound and 2-methyl-2-lower alkyl-6-substituted penam-3-carboxylicacid-1-oxide. Subsequent reaction of I and II included deacylation, ester hydrolysis, S-oxidn. and substitution at R2..

公开(公告)号：KR820001611B1

公开(公告)日：1982-09-08

申请号：KR820002707

申请日：1982-06-17

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： KURODA YOSHIO ,  IKUCHI EIGO ,  IMANAKA HIROSHI ,  OKUHARA MASAKURI ,  AOKI HASTUO ,  KAMIYA TAKASHI

IPC: C07F9/40

Abstract: The title compds.(If; R1α = lower alkenoyl; A = lower alkyene), useful as antibiotics and bactericides, were prepd. by the reaction of Ie≮HN(OH)AP(O)(OH)2≉ and R1α-OH. phosphonylation of R1N(0R2)AX1≮R1 = olwer alkoxycarbonyl, a enesulfonyl; R2 = ar(lower)alkyl; X1 = acid residue≉wich POR3(0R3)2 [R3 = H, ester residue; R3 α=ester residue, followed by hy2 drolysis to give If.

公开(公告)号：KR810001351B1

公开(公告)日：1981-10-15

申请号：KR810003177

申请日：1981-08-28

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： KAMIYA TAKASHI ,  NAKAKUCHI OSAMU ,  TERAJI TSUTOMU ,  OKU TERUO ,  TAKAYA TAKAO ,  HASHIMOTO MASASHI

IPC: C07D501/60

公开(公告)号：KR820001610B1

公开(公告)日：1982-09-08

申请号：KR770001737

申请日：1977-07-27

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： KURODA YOSHIO ,  IKUCHI EIGO ,  IMANAKA HIROSHI ,  OKUHAMA MASAKUNI ,  AOKI HASTUO ,  KAMIYA TAKASHI

IPC: C07F9/40

Abstract: The title compds.(If; R1α = olwer alkanoyl; A = lower alkylene or lower alkenyiene),useful as antibiotics and bactericides, were prepd. by the reaction of HN(OH)AP(O)(0H)2≮Ie≉and R1α-OH. Ie was prepd. by the hydrolysis of R1N(OR2)A-P(O)(OR3α)2 ≮Ib; R1 = H, lower alkoxycarbonyl, arene suifonyl ; R2 = H, ar(olwer)alkyl, lower alkoxycarbonyl; R3α = ester residue obtained from the reaction of X2AP(O)(OR3α)2 2≮ X2 = acid residue≉and R1NH(OR2).

公开(公告)号：KR810001350B1

公开(公告)日：1981-10-15

申请号：KR770001493

申请日：1977-06-28

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： HASHIMOTO MASASHI ,  KAMIYA TAKASHI ,  OKU TERUO ,  NAKAKUCHI OSAMU ,  TERAJI TSUTOMU ,  TAKAYA TAKAO

IPC: C07D501/60

公开(公告)号：KR790001314B1

公开(公告)日：1979-09-24

申请号：KR780002192

申请日：1978-07-14

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： KAMIYA TAKASHI ,  TERAZI TSUTOMU ,  NAGAKUCHI MOSHAMU ,  HASHIMOTO MASHASHI

Abstract: Title compd. I(R1 = amino or substd. amino, R2 = carboxyl or substd. carboxyl, R3 = lower alkyl, Y = residue of nucleophile) was prepared from compd. II(Z = radical which is convertible to residue of nucleophile) or compd. III, which were prepared by reacting 2-methyl-2-lower alkyl-6- substd. penam-3-carboxylic acid-1-oxide with thiol or reacting above product with ammonia or amine. compd. I has antibacterial activity.

公开(公告)号：KR790000710B1

公开(公告)日：1979-06-25

申请号：KR740001559

申请日：1974-02-19

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： KAMIYA TAKASHI ,  NAKAGUTSI OSAMU ,  TERAJI TSUTOMU ,  OKU TERUO ,  HASHIMOTO MASASHI

Abstract: 2-alkyl-7-aminoacylamino-2(or 3)-cephem-4-carboxylic acid(I; R1 = acyl aminoacylamino; R2 = alkyl; X = S, SO) and their CO2H derivs., having antibacterial property, were prepd. by elimination of amino protecting group in the 2-alkyl-7-substituted acylamino-2(or 3)-cephem-4-carboxylic acid (II; R1 = aminoacylamino), their CO2H derivs., or salts.

公开(公告)号：US3923977A

公开(公告)日：1975-12-02

申请号：US45821174

申请日：1974-04-05

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： AOKI HATSUO ,  HOSODA JUNJI ,  KOMORI TADAAKI ,  IZEKI MANABU ,  KUBOCHI YOSHIAKI ,  KAMIYA TAKASHI ,  IMANAKA HIROSHI

IPC: A61K35/74 ,  C07D205/08 ,  C07G11/00 ,  A61K35/00

CPC classification number: C07D205/08 ,  C07G11/00 ,  Y10S435/872

Abstract: An antibiotic FR-1923 substance which is active against a pathogenic bacteria and useful as an effective antimicrobial agent in treatment of infections disease caused by bacteria, the antibiotic FR-1923 substance being produced by fermentation of Nocardia uniformis var. tsuyamanensis ATCC 21806 and its mutant in a nutrient medium.

Abstract translation: 抗菌素FR-1923物质，其对病原菌具有活性，可用作治疗由细菌引起的感染性疾病的有效抗微生物剂，抗生素FR-1923物质是由诺卡氏菌发酵制备的。 tsuyamanensis ATCC 21806及其在营养培养基中的突变体。

公开(公告)号：US3923790A

公开(公告)日：1975-12-02

申请号：US46338274

申请日：1974-04-23

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： IMANAKA HIROSHI ,  KAMIYA TAKASHI ,  MAENO SHIZUO ,  MIYOSHI TOSHIO ,  MIYAIRI NORIMASA ,  AOKI HATSUO ,  KOHSAKA MASANOBU ,  KOMORI TADAAKI ,  SAKAI HEIICHI

IPC: A61K35/74 ,  C07D498/08 ,  C07H9/06 ,  C12P1/06 ,  C12R1/465

CPC classification number: C07D498/08 ,  C07H9/06 ,  Y10S435/886

Abstract: An antibiotic WS-4545 and the acyl derivatives thereof, which are active against a pathogenic bacteria and useful as an effective antimicrobial agent in treatment of infectious diseases caused by bacteria, the antibiotic WS-4545 being produced by fermentation of Streptomyces sapporonensis ATCC 21532 and its mutants in a nutrient medium and the acyl derivatives of said antibiotic being prepared by acylating said antibiotic with an acylating agent.

Abstract translation: 抗生素WS-4545及其酰基衍生物，其对病原菌具有活性并且可用作治疗由细菌引起的感染性疾病的有效抗微生物剂，抗生素WS-4545是通过发酵链霉菌（Streptomyces sapporonensis）ATCC 21532及其 营养培养基中的突变体和所述抗生素的酰基衍生物通过用酰化剂酰化所述抗生素来制备。

公开(公告)号：US3904607A

公开(公告)日：1975-09-09

申请号：US41825973

申请日：1973-11-23

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： KAMIYA TAKASHI ,  TERAJI TSUTOMU ,  HASHIMOTO MASASHI

IPC: A61K31/41 ,  C07D20060101 ,  C07D499/04 ,  C07D499/06 ,  C07D499/12 ,  C07D499/21 ,  C07D499/24 ,  C07D499/28 ,  C07D499/32 ,  C07D499/42 ,  C07D499/44 ,  C07D499/48 ,  C07D499/74 ,  C07D499/90 ,  C07D99/16

CPC classification number: C07D499/04 ,  C07D499/44 ,  Y02P20/55

Abstract: Compounds having the formula

WHEREIN R1 is amino or a substituted amino, R2 is carboxy or a protected carboxy, R3 is lower alkyl, R4 is lower alkylene and X is -S- or

These compounds possess antimicrobial activities and are useful for the preparation of pharmaceutical compositions containing the same.