公开(公告)号：KR840001989B1

公开(公告)日：1984-10-26

申请号：KR840003711

申请日：1984-06-29

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： DAKAYA DAKAO ,  MATSUGI DAKASHI ,  KAWABADA KOJI ,  DAKASUGI HISASHI ,  YAMANAKA HIDEAKI

IPC: C07D501/22

公开(公告)号：KR840001988B1

公开(公告)日：1984-10-26

申请号：KR840003709

申请日：1984-06-29

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： DAKAYA DAKAO ,  MATSUGI DAKASHI ,  KAWABADA KOJI ,  DAKASUGI HISASHI ,  YAMANAKA HIDEAKI

IPC: C07D501/22

公开(公告)号：KR840001987B1

公开(公告)日：1984-10-26

申请号：KR840003708

申请日：1984-06-29

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： DAKAYA DAKAO ,  MATSUGI DAKASHI ,  KAWABADA KOJI ,  DAKASUGI HISASHI ,  YAMANAKA HIDEAKI

IPC: C07D501/22

公开(公告)号：KR840002008B1

公开(公告)日：1984-10-27

申请号：KR840003707

申请日：1984-06-29

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： DAKAYA DAKAO ,  MATSUGI DAKASHI ,  KAWABADA KOJI ,  DAKASUGI HISASHI ,  YAMANAKA HIDEAKI

IPC: C07D501/22

公开(公告)号：KR840002009B1

公开(公告)日：1984-10-27

申请号：KR840003710

申请日：1984-06-29

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： DAKAYA DAKAO ,  MATSUGI DAKASHI ,  KAWABADA KOJI ,  DAKASUGI HISASHI ,  YAMANAKA HIDEAKI

IPC: C07D501/22

公开(公告)号：KR840001990B1

公开(公告)日：1984-10-26

申请号：KR840003712

申请日：1984-06-29

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： DAKAYA DAKAO ,  MATSUGI DAKASHI ,  KAWABADA KOJI ,  DAKASUGI HISASHI ,  YAMANAKA HIDEAKI

IPC: C07D501/22

公开(公告)号：KR840001827B1

公开(公告)日：1984-10-22

申请号：KR800004426

申请日：1980-11-19

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： DAKAYA DAKAO ,  MATSUGI DAKASHI ,  KAWABADA KOJI ,  DAKASUGI HISASHI ,  YAMANAKA HIDEAKI

IPC: C07D501/22

公开(公告)号：FR2534922A1

公开(公告)日：1984-04-27

申请号：FR8314220

申请日：1983-09-06

Applicant: FUJISAWA PHARMACEUTICAL CO ,  FUJISAWA PHARMACEUTICAL CO

Inventor： TAKAYA TAKAO ,  TAKAO TAKAYA HISASHI TAKASUGI HIDEAKI YAMANAKA KENJI MIYAI ET YOSHIKAZU INOUE ,  TAKASUGI HISASHI ,  YAMANAKA HIDEAKI ,  MIYAI KENJI ,  INOUE YOSHIKAZU

IPC: A61K31/54 ,  A61K31/545 ,  A61K20060101 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/14 ,  C07D501/18 ,  C07D501/20 ,  C07D501/22 ,  C07D501/24 ,  C07D501/48

Abstract: DES COMPOSES DE CEPHEM AYANT LA FORMULE: (CF DESSIN DANS BOPI) OU R EST UN GROUPE AMINO OU ACYLAMINO, R EST UN GROUPE ALKYLE INFERIEUR ET Y EST CH OU N, ET LEURS SELS PHARMACEUTIQUEMENT ACCEPTABLES, SONT DES PRODUITS UTILISES COMME AGENTS ANTIBACTERIENS.

公开(公告)号：JPH06279452A

公开(公告)日：1994-10-04

申请号：JP20155091

申请日：1991-05-10

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： TAKATANI TAKAO ,  TAKASUGI HISASHI ,  MASUGI TAKASHI ,  YAMANAKA HIDEAKI ,  KAWABATA KOJI

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D209/48 ,  C07D213/75 ,  C07D239/42 ,  C07D257/06 ,  C07D271/06 ,  C07D271/07 ,  C07D277/20 ,  C07D277/46 ,  C07D277/48 ,  C07D277/56 ,  C07D285/08 ,  C07D417/12 ,  C07D501/06 ,  C07D501/18 ,  C07D501/20 ,  C07D501/22 ,  C07D501/24 ,  C07D501/36 ,  C07F9/6561

Abstract: PURPOSE:To obtain a novel compound which is an intermediate for synthesizing a 7-acylamino-3-vinylcephalosporic acid useful as an antibiotic. CONSTITUTION:A compound of formula I [RA is group of formula II or formula III (R is protected amino; R is protected carboxy; R is amino; R is lower alkyl, carboxyl, etc.,) RB is either one in the group of formulae: CH2-X , CH2 P (R )3.X , CH=P(R )3 (R is aryl; X , X are each halogen); R is carboxyl], e.g.7-(5-benzamide-5-benzhydryloxycarbonyl pentanamide)-3-chloromethyl-3- cephem-4-carboxylic acid benzhydryl ester. The compound of formula I is obtained by reacting a compound of formula IV with a halogenating agent (e.g. phosphorus pentachloride) in the presence of a base (e.g. pyridine) in a solvent (e.g. methylene chloride) under cooling to heating.

公开(公告)号：JPH05222058A

公开(公告)日：1993-08-31

申请号：JP6913392

申请日：1992-02-17

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： YAMANAKA HIDEAKI ,  NAGAHISA YOSHITERU ,  OGAWA TAKAHIRO ,  SAKANE KAZUO

IPC: A61K31/545 ,  A61P31/04 ,  C07D519/00 ,  C07D519/06

Abstract: PURPOSE:To obtain a new compound capable of preventing growth of diffuse pathogenic bacteria including Gram-negative bacteria, Gram-positive bacteria and useful as antimicrobial agents, etc. CONSTITUTION:A compound of formula I [R is (protected)amino; R is H or organic group; R is (substituted)pyrrolopyridium; R is (protected)carboxy or COO ; X is N or CH; Y is anion; n is 0 or 1], e.g. 7-beta-[2-(2-aminothiazol-4- yl)-2-methoxyimino-acetamido]-3-[4-)1H-pyrrolo[3,2--4]pyridinio)]methy l-3- cephem-4-carboxylate. Furthermore, the compound of formula I is obtained by reacting a compound of formula II with a compound of formula III in an organic solvent such as acetonitrile in the presence of a condensing agent such as N,N'-dicyclohexylcarbodiimide.