公开(公告)号：KR810001351B1

公开(公告)日：1981-10-15

申请号：KR810003177

申请日：1981-08-28

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： KAMIYA TAKASHI ,  NAKAKUCHI OSAMU ,  TERAJI TSUTOMU ,  OKU TERUO ,  TAKAYA TAKAO ,  HASHIMOTO MASASHI

IPC: C07D501/60

公开(公告)号：KR800001383B1

公开(公告)日：1980-11-26

申请号：KR760000266

申请日：1976-02-04

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： TAKASUGI HISASHI ,  TAKAYA TAKAO ,  MASUGI TAKASHI ,  KOUCHI HIROMU

IPC: A61K31/545 ,  C07D501/36

Abstract: Title compds.(I; R1 = H, halogen, hydroxy, nitro, lower alkoxy or acylamino; R2 = H, acy1; R3 = lower alkanoyloxy, lower alky1, carbamoyloxy), useful as bactericides, were prepared by reaction of 7-amino-3-substituted-3-cephem-4-carboxylic acid(II) and α,α-disubstituted acetic acid(III). Thus, acylation of 1.64 g 7-amino-3-cephem-4-carboxylic acid with 2.1 g bis(trimethylsily1)acetamide, followed by hydrolysis of the dichloroacety1 group to give I.

公开(公告)号：KR810001350B1

公开(公告)日：1981-10-15

申请号：KR770001493

申请日：1977-06-28

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： HASHIMOTO MASASHI ,  KAMIYA TAKASHI ,  OKU TERUO ,  NAKAKUCHI OSAMU ,  TERAJI TSUTOMU ,  TAKAYA TAKAO

IPC: C07D501/60

公开(公告)号：FR2534922A1

公开(公告)日：1984-04-27

申请号：FR8314220

申请日：1983-09-06

Applicant: FUJISAWA PHARMACEUTICAL CO ,  FUJISAWA PHARMACEUTICAL CO

Inventor： TAKAYA TAKAO ,  TAKAO TAKAYA HISASHI TAKASUGI HIDEAKI YAMANAKA KENJI MIYAI ET YOSHIKAZU INOUE ,  TAKASUGI HISASHI ,  YAMANAKA HIDEAKI ,  MIYAI KENJI ,  INOUE YOSHIKAZU

IPC: A61K31/54 ,  A61K31/545 ,  A61K20060101 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/14 ,  C07D501/18 ,  C07D501/20 ,  C07D501/22 ,  C07D501/24 ,  C07D501/48

Abstract: DES COMPOSES DE CEPHEM AYANT LA FORMULE: (CF DESSIN DANS BOPI) OU R EST UN GROUPE AMINO OU ACYLAMINO, R EST UN GROUPE ALKYLE INFERIEUR ET Y EST CH OU N, ET LEURS SELS PHARMACEUTIQUEMENT ACCEPTABLES, SONT DES PRODUITS UTILISES COMME AGENTS ANTIBACTERIENS.

公开(公告)号：FR2378786A1

公开(公告)日：1978-08-25

申请号：FR7739259

申请日：1977-12-27

Applicant: FUJISAWA PHARMACEUTICAL CO ,  FUJISAWA PHARMACEUTICAL CO

Inventor： TAKAYA TAKAO ,  TAKAO TAKAYA TAKASHI MASUGI TAKASHI OGINO ET KIYOSHI TSUJI ,  MASUGI TAKASHI ,  OGINO TAKASHI ,  TSUJI KIYOSHI

IPC: A61K20060101 ,  A61K31/545 ,  C07D501/34 ,  A61K31/546 ,  A61P31/04 ,  C07C20060101 ,  C07D279/10 ,  C07D279/12 ,  C07D327/06 ,  C07D339/06 ,  C07D339/08 ,  C07D501/20 ,  C07D501/36

Abstract: L'invention concerne de nouveaux dérivés de céphalosporine de formule :

公开(公告)号：FR2313069A1

公开(公告)日：1976-12-31

申请号：FR7616707

申请日：1976-06-02

Applicant: FUJISAWA PHARMACEUTICAL CO ,  FUJISAWA PHARMACEUTICAL CO

Inventor： KOCHI HIROMU ,  TAKAYA TAKAO ,  TAKAO TAKAYA TAKASHI MASUGI HISASHI TAKASUGI ET HIROMU KOCHI ,  MASUGI TAKASHI ,  TAKASUGI HISASHI

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/34 ,  C07D257/04 ,  C07D277/20 ,  C07D277/40 ,  C07D277/46 ,  C07D277/48 ,  C07D277/50 ,  C07D501/24 ,  C07D501/36

公开(公告)号：FR2383938A1

公开(公告)日：1978-10-13

申请号：FR7819377

申请日：1978-06-28

Applicant: FUJISAWA PHARMACEUTICAL CO ,  FUJISAWA PHARMACEUTICAL CO

Inventor： TAKAYA TAKAO ,  TAKAO TAKAYA TAKASHI MASUGI TAKASHI OGINO ET KIYOSHI TSUJI ,  MASUGI TAKASHI ,  OGINO TAKASHI ,  TSUJI KIYOSHI

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/34 ,  C07C20060101 ,  C07D279/10 ,  C07D279/12 ,  C07D327/06 ,  C07D339/06 ,  C07D339/08 ,  C07D501/20 ,  C07D501/36 ,  C07D283/00 ,  C07D339/00

Abstract: Acides acétiques disubstitués. Ces acides acétiques disubstitués ont la formule :

公开(公告)号：CA1339739C

公开(公告)日：1998-03-17

申请号：CA577072

申请日：1988-09-02

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： TAKAYA TAKAO ,  SAKANE KAZUO ,  MIYAI KENZI ,  KAWABATA KOHJI

IPC: C07D501/04 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/46 ,  C07F7/10

Abstract: There are described compounds of the formula (see fig. I) wherein R1 is amino or protected amino, R2 is lower alkyl or lower alkenyl, R3 is lower alkyl, hydroxy(lower)alkyl or protected hydroxy(lower)alkyl, R4 is amino, protected amino, lower alkylamino, protected lower alkylamino, carboxy-(lower)alkylamino, N-¢protected carboxy(lower)alkyl!amino and R7 is hydrogen or lower alkyl, and a pharmaceutically acceptable salt thereof. Process for the preparation of these compounds, pharmaceutical composition comprising same, as well as a method of treating infectious diseases in human beings and animals using these compounds are also described.

公开(公告)号：GR3024743T3

公开(公告)日：1997-12-31

申请号：GR970402388

申请日：1997-09-17

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： TAKAYA TAKAO ,  SAKANE KAZUO ,  MIYAI KENZI ,  KAWABATA KOHJI ,  OKUDA SHINYA ,  OHKI HIDENORI ,  YAMANAKA HIDEAKI

IPC: C07D501/48 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/00 ,  C07D501/46

公开(公告)号：CA1338820C

公开(公告)日：1996-12-31

申请号：CA616166

申请日：1991-09-18

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： TAKAYA TAKAO ,  SAKANE KAZUO ,  MIYAI KENZI ,  KAWABATA KOHJI

IPC: C07D501/18

Abstract: Compounds of the formula: wherein R3 is lower alkyl, hydroxy (lower) alkyl or a protected hydroxy (lower) alkyl, R4 is amino or a protected amino group, and R5 is hydrogen or lower alkyl. The salts of these compounds and the preparation of the compounds are also disclosed. These compounds are useful intermediates for the preparation of cephem compounds which are highly active against a number of pathogenic microorganisms.