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1.发明申请DEVICES AND METHODS FOR ENHANCED MICRONEEDLE PENETRATION OF BIOLOGICAL BARRIERS 审中-公开用于增强生物障碍的微生物渗透的装置和方法
公开(公告)号：WO0074763A3
公开(公告)日：2001-07-05
申请号：PCT/US0015312
申请日：2000-06-02
Applicant: GEORGIA TECH RES INST
Inventor： PRAUSNITZ MARK R , ALLEN MARK G , HENRY SEBASTIEN , MCALLISTER DEVIN V , ACKLEY DONALD E , GUJRAL INDER-JEET , JACKSON THOMAS
CPC classification number: B81C1/00111 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150099 , A61B5/150221 , A61B5/150229 , A61B5/150274 , A61B5/150389 , A61B5/150412 , A61B5/150946 , A61B5/150969 , A61B5/150984 , A61B5/157 , A61B10/0045 , A61B17/205 , A61B2010/008 , A61K9/0021 , A61M5/1723 , A61M5/422 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0053 , B81B2201/055
Abstract: Microneedle devices are provided for delivery of drugs across biological tissue and for controlled sampling of biological fluids in a minimally-invasive, painless, and convenient manner. The devices permit 1) drug delivery at clinically relevant rates across or into skin or other tissue barriers, and/or 2) in vivo sensing or withdrawal of biological fluids from the body, particularly from or through the skin or other tissue barriers. Drug delivery devices preferably include a plurality of hollow microneedles attached to or integrated into a substrate, and at least one reservoir (containing drug) selectably in communication with the microneedles, wherein the amount of drug to be delivered can be selectively altered. Withdrawal or sensing microneedle devices preferably include microneedles attached to or integrated into a substrate, and at least one collection chamber and/or sensor in communication with the microneedles.
Abstract translation: 提供微针装置用于在生物组织之间递送药物，并以微创，无痛和方便的方式对生物流体进行受控采样。 这些装置允许1）在临床相关的速率穿过或进入皮肤或其他组织屏障的药物递送，和/或2）生物体液体从身体，特别是从皮肤或通过皮肤或其他组织屏障的体内检测或撤出。 药物递送装置优选地包括附接到基底上或整合到基底中的多个中空微针，以及可选地与微针连通的至少一个储存器（含有药物），其中可以选择性地改变待递送的药物的量。 提取或感测微针装置优选地包括附接到或集成到基底中的微针，以及与微针通信的至少一个收集室和/或传感器。
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公开(公告)号：EP1086214A4
公开(公告)日：2007-05-02
申请号：EP99928580
申请日：1999-06-10
Applicant: GEORGIA TECH RES INST
Inventor： PRAUSNITZ MARK R , ALLEN MARK G , MCALLISTER DEVIN V , HENRY SEBASTIEN , CROS FLORENT PAUL MARCEL
IPC: C12N15/09 , A61B5/00 , A61B5/15 , A61B17/20 , A61K9/70 , A61M35/00 , A61M37/00 , A61N1/30 , B81C1/00 , C12N15/00
CPC classification number: B81C1/00111 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150282 , A61B5/150984 , A61B17/205 , A61K9/0021 , A61M37/0015 , A61M2037/003 , A61M2037/0053 , A61N1/303 , B81B2201/055
Abstract: Microneedle devices are provided for transport of therapeutic and biological molecules across tissue barriers. In a preferred embodiment, the microneedle devices permit drug delivery (or removal or sensing of body fluids) at clinically relevant rates across skin or other tissue barriers, without damage, pain, or irritation to the tissue. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver fluid material into or across a biological barrier from one or more chambers in fluid connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.
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公开(公告)号：DE60044084D1
公开(公告)日：2010-05-12
申请号：DE60044084
申请日：2000-06-02
Applicant: GEORGIA TECH RES INST
Inventor： PRAUSNITZ MARK R , ALLEN MARK G , HENRY SEBASTIEN , MCALLISTER DEVIN V , ACKLEY DONALD E , GUJRAL INDER-JEET , JACKSON THOMAS
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公开(公告)号：CA2330207C
公开(公告)日：2005-08-30
申请号：CA2330207
申请日：1999-06-10
Applicant: GEORGIA TECH RES INST
Inventor： PRAUSNITZ MARK R , ALLEN MARK G , CROS FLORENT PAUL MARCEL , HENRY SEBASTIEN , MCALLISTER DEVIN V
IPC: C12N15/09 , A61B5/00 , A61B5/15 , A61B17/20 , A61K9/70 , A61M35/00 , A61M37/00 , A61N1/30 , B81C1/00 , A61M5/158 , A61M5/00 , C12N15/00
Abstract: Microneedle devices for transport of therapeutic and diagnostic materials and/or energy across tissue barriers, and methods for manufacturing the devices, are provided. The microneedles are hollow and/or porous and have diameters between about l0nm and lmm. The microneedle devices permit drug delivery (or removal or sensing of body fluids) at clinically relevant rates across skin or other tissue barriers, without damage, pain, or irritation to the tissue. Microfabrication techniques are used to cost-effectively produce arrays of microneedles from metals, silicon, silicon dioxide, ceramic, and polymeric materials. Methods are provided for making porous or hollow microneedles.
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公开(公告)号：AU2004200303A1
公开(公告)日：2004-02-19
申请号：AU2004200303
申请日：2004-01-30
Applicant: GEORGIA TECH RES INST
Inventor： PRAUSNITZ MARK R , CROS FLORENT PAUL MARCELL , HENRY SEBASTIEN , MCALLISTER DEVIN V , ALLEN MARK G
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Patent Agency Ranking
公开(公告)号：ES2928783T3
公开(公告)日：2022-11-22
申请号：ES14848387
申请日：2014-09-30
Applicant: GEORGIA TECH RES INST
Inventor： MCALLISTER DEVIN , PRAUSNITZ MARK , HENRY SEBASTIEN , NORMAN JAMES J
IPC: A61M37/00
Abstract: Realizaciones de la presente solicitud proporcionan parches y sistemas de microagujas, y métodos para el uso de dichos parches y sistemas. En un aspecto, se proporciona un parche de microagujas que incluye una porción de lengüeta para manipular el parche de microagujas. En otro aspecto, se proporciona un sistema que incluye un parche de microagujas y una bandeja para alojar el parche de microagujas. En otro aspecto más, se proporcionan varios indicadores que proporcionan información antes, durante y después de la administración del parche de microagujas. Ventajosamente, los parches y sistemas de microagujas descritos proporcionan un manejo mejorado y facilidad de aplicación de los parches de microagujas a la piel para la administración de agentes terapéuticos. (Traducción automática con Google Translate, sin valor legal)
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公开(公告)号：CA2981974A1
公开(公告)日：2015-10-29
申请号：CA2981974
申请日：2015-04-24
Applicant: GEORGIA TECH RES INST
Inventor： MCALLISTER DEVIN , PRAUSNITZ MARK , HENRY SEBASTIEN , GUO XIN DONG
IPC: A61M5/158
Abstract: A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold.
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公开(公告)号：AT462468T
公开(公告)日：2010-04-15
申请号：AT00939538
申请日：2000-06-02
Applicant: GEORGIA TECH RES INST
Inventor： PRAUSNITZ MARK , ALLEN MARK , HENRY SEBASTIEN , MCALLISTER DEVIN , ACKLEY DONALD , GUJRAL INDER-JEET , JACKSON THOMAS
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公开(公告)号：AU2005200910A1
公开(公告)日：2005-03-24
申请号：AU2005200910
申请日：2005-03-01
Applicant: GEORGIA TECH RES INST
Inventor： JACKSON THOMAS , GUJRAL INDER-JEET , ACKLEY DONALD E , MCALLISTER DEVIN V , HENRY SEBASTIEN , ALLEN MARK G , PRAUSNITZ MARK R
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公开(公告)号：CA2376128C
公开(公告)日：2009-01-06
申请号：CA2376128
申请日：2000-06-02
Applicant: GEORGIA TECH RES INST
Inventor： HENRY SEBASTIEN , MCALLISTER DEVIN V , JACKSON THOMAS , ACKLEY DONALD E , GUJRAL INDER-JEET , ALLEN MARK G , PRAUSNITZ MARK R
IPC: A61M37/00 , A61B5/00 , A61B5/15 , A61B5/151 , A61B5/157 , A61B17/20 , A61F7/00 , A61M5/172 , A61M5/42 , A61N1/04 , A61N5/06 , B81C1/00
Abstract: Microneedle devices are provided for delivery of drugs across biological tissue and for controlled sampling of biological fluids in a minimally-invasive, painless, and convenient manner. The devices permit 1) drug delivery at clinically relevant rates across or into skin or other tissue barriers, and/or 2) in vivo sensin g or withdrawal of biological fluids from the body, particularly from or through the skin or other tissue barriers. Drug delivery devices preferably include a plurality of hollow microneedles attached to or integrated into a substrate, and at least one reservoir (containing drug) selectably in communication with the microneedles, wherein the amount of drug to be delivered can be selectively altered. Withdrawal or sensing microneedle devices preferably include microneedles attached to or integrated into a substrate, and at leas t one collection chamber and/or sensor in communication with the microneedles.
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