公开(公告)号：WO0074763A3

公开(公告)日：2001-07-05

申请号：PCT/US0015312

申请日：2000-06-02

Applicant: GEORGIA TECH RES INST

Inventor： PRAUSNITZ MARK R ,  ALLEN MARK G ,  HENRY SEBASTIEN ,  MCALLISTER DEVIN V ,  ACKLEY DONALD E ,  GUJRAL INDER-JEET ,  JACKSON THOMAS

IPC: A61B5/00 ,  A61B5/15 ,  A61B17/20 ,  A61M5/172 ,  A61M5/42 ,  A61M37/00 ,  B81C1/00 ,  A61B10/00

CPC classification number: B81C1/00111 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150274 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150946 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/157 ,  A61B10/0045 ,  A61B17/205 ,  A61B2010/008 ,  A61K9/0021 ,  A61M5/1723 ,  A61M5/422 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0053 ,  B81B2201/055

Abstract: Microneedle devices are provided for delivery of drugs across biological tissue and for controlled sampling of biological fluids in a minimally-invasive, painless, and convenient manner. The devices permit 1) drug delivery at clinically relevant rates across or into skin or other tissue barriers, and/or 2) in vivo sensing or withdrawal of biological fluids from the body, particularly from or through the skin or other tissue barriers. Drug delivery devices preferably include a plurality of hollow microneedles attached to or integrated into a substrate, and at least one reservoir (containing drug) selectably in communication with the microneedles, wherein the amount of drug to be delivered can be selectively altered. Withdrawal or sensing microneedle devices preferably include microneedles attached to or integrated into a substrate, and at least one collection chamber and/or sensor in communication with the microneedles.

Abstract translation: 提供微针装置用于在生物组织之间递送药物，并以微创，无痛和方便的方式对生物流体进行受控采样。 这些装置允许1）在临床相关的速率穿过或进入皮肤或其他组织屏障的药物递送，和/或2）生物体液体从身体，特别是从皮肤或通过皮肤或其他组织屏障的体内检测或撤出。 药物递送装置优选地包括附接到基底上或整合到基底中的多个中空微针，以及可选地与微针连通的至少一个储存器（含有药物），其中可以选择性地改变待递送的药物的量。 提取或感测微针装置优选地包括附接到或集成到基底中的微针，以及与微针通信的至少一个收集室和/或传感器。

公开(公告)号：EP1086214A4

公开(公告)日：2007-05-02

申请号：EP99928580

申请日：1999-06-10

Applicant: GEORGIA TECH RES INST

Inventor： PRAUSNITZ MARK R ,  ALLEN MARK G ,  MCALLISTER DEVIN V ,  HENRY SEBASTIEN ,  CROS FLORENT PAUL MARCEL

IPC: C12N15/09 ,  A61B5/00 ,  A61B5/15 ,  A61B17/20 ,  A61K9/70 ,  A61M35/00 ,  A61M37/00 ,  A61N1/30 ,  B81C1/00 ,  C12N15/00

CPC classification number: B81C1/00111 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150984 ,  A61B17/205 ,  A61K9/0021 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  A61N1/303 ,  B81B2201/055

Abstract: Microneedle devices are provided for transport of therapeutic and biological molecules across tissue barriers. In a preferred embodiment, the microneedle devices permit drug delivery (or removal or sensing of body fluids) at clinically relevant rates across skin or other tissue barriers, without damage, pain, or irritation to the tissue. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver fluid material into or across a biological barrier from one or more chambers in fluid connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.

公开(公告)号：AU2005200910A1

公开(公告)日：2005-03-24

申请号：AU2005200910

申请日：2005-03-01

Applicant: GEORGIA TECH RES INST

Inventor： JACKSON THOMAS ,  GUJRAL INDER-JEET ,  ACKLEY DONALD E ,  MCALLISTER DEVIN V ,  HENRY SEBASTIEN ,  ALLEN MARK G ,  PRAUSNITZ MARK R

IPC: A61B10/00 ,  A61M37/00

公开(公告)号：AU5461300A

公开(公告)日：2000-12-28

申请号：AU5461300

申请日：2000-06-02

Applicant: GEORGIA TECH RES INST

Inventor： PRAUSNITZ MARK R ,  ALLEN MARK G ,  HENRY SEBASTIEN ,  MCALLISTER DEVIN V ,  ACKLEY DONALD E ,  GUJRAL INDER-JEET ,  JACKSON THOMAS

IPC: A61B5/00 ,  A61B5/15 ,  A61B17/20 ,  A61M5/172 ,  A61M5/42 ,  A61M37/00 ,  B81C1/00 ,  A61B10/00

公开(公告)号：CA2376128A1

公开(公告)日：2000-12-14

申请号：CA2376128

申请日：2000-06-02

Applicant: GEORGIA TECH RES INST

Inventor： PRAUSNITZ MARK R ,  ALLEN MARK G ,  HENRY SEBASTIEN ,  ACKLEY DONALD E ,  GUJRAL INDER-JEET ,  MCALLISTER DEVIN V ,  JACKSON THOMAS

IPC: A61B5/00 ,  A61B5/15 ,  A61B17/20 ,  A61M5/172 ,  A61M5/42 ,  A61M37/00 ,  B81C1/00 ,  A61B10/00

Abstract: Microneedle devices are provided for delivery of drugs across biological tissue and for controlled sampling of biological fluids in a minimally- invasive, painless, and convenient manner. The devices permit 1) drug delive ry at clinically relevant rates across or into skin or other tissue barriers, and/or 2) in vivo sensing or withdrawal of biological fluids from the body, particularly from or through the skin or other tissue barriers. Drug deliver y devices preferably include a plurality of hollow microneedles attached to or integrated into a substrate, and at least one reservoir (containing drug) selectably in communication with the microneedles, wherein the amount of dru g to be delivered can be selectively altered. Withdrawal or sensing microneedl e devices preferably include microneedles attached to or integrated into a substrate, and at least one collection chamber and/or sensor in communicatio n with the microneedles.

公开(公告)号：CA2376128C

公开(公告)日：2009-01-06

申请号：CA2376128

申请日：2000-06-02

Applicant: GEORGIA TECH RES INST

Inventor： HENRY SEBASTIEN ,  MCALLISTER DEVIN V ,  JACKSON THOMAS ,  ACKLEY DONALD E ,  GUJRAL INDER-JEET ,  ALLEN MARK G ,  PRAUSNITZ MARK R

IPC: A61M37/00 ,  A61B5/00 ,  A61B5/15 ,  A61B5/151 ,  A61B5/157 ,  A61B17/20 ,  A61F7/00 ,  A61M5/172 ,  A61M5/42 ,  A61N1/04 ,  A61N5/06 ,  B81C1/00

Abstract: Microneedle devices are provided for delivery of drugs across biological tissue and for controlled sampling of biological fluids in a minimally-invasive, painless, and convenient manner. The devices permit 1) drug delivery at clinically relevant rates across or into skin or other tissue barriers, and/or 2) in vivo sensin g or withdrawal of biological fluids from the body, particularly from or through the skin or other tissue barriers. Drug delivery devices preferably include a plurality of hollow microneedles attached to or integrated into a substrate, and at least one reservoir (containing drug) selectably in communication with the microneedles, wherein the amount of drug to be delivered can be selectively altered. Withdrawal or sensing microneedle devices preferably include microneedles attached to or integrated into a substrate, and at leas t one collection chamber and/or sensor in communication with the microneedles.

公开(公告)号：AU2008200252A1

公开(公告)日：2008-02-07

申请号：AU2008200252

申请日：2008-01-18

Applicant: GEORGIA TECH RES INST

Inventor： CROS FLORENT PAUL MARCEL ,  MCALLISTER DEVIN V ,  PRAUSNITZ MARK R ,  HENRY SEBASTIEN ,  ALLEN MARK G

IPC: C12N15/00

公开(公告)号：CA2510389A1

公开(公告)日：1999-12-16

申请号：CA2510389

申请日：1999-06-10

Applicant: GEORGIA TECH RES INST

Inventor： ALLEN MARK G ,  PRAUSNITZ MARK R ,  MCALLISTER DEVIN V ,  HENRY SEBASTIEN ,  CROS FLORENT PAUL MARCEL

IPC: A61M5/158 ,  A61M37/00 ,  B29C45/00

公开(公告)号：CA3016984A1

公开(公告)日：2016-10-20

申请号：CA3016984

申请日：2016-04-18

Applicant: GEORGIA TECH RES INST

Inventor： MCALLISTER DEVIN V ,  PRAUSNITZ MARK R ,  HENRY SEBASTIEN

IPC: A61M37/00

Abstract: The devices 400, 500 include microneedles 450, 550 that may be separable from the drug delivery devices, control drug release rate and/or direction, or a combination thereof. When the microneedles are separable, a force applied to the drug delivery devices may be effective to penetrate a biological tissue with the microneedles and then to separate the microneedles from the drug delivery devices. The drug delivery devices may be capable of achieving discrete periods of drug release.

公开(公告)号：DE69941696D1

公开(公告)日：2010-01-07

申请号：DE69941696

申请日：1999-06-10

Applicant: GEORGIA TECH RES INST

Inventor： PRAUSNITZ MARK R ,  ALLEN MARK G ,  MCALLISTER DEVIN V ,  HENRY SEBASTIEN ,  CROS FLORENT PAUL

IPC: C12N15/00 ,  A61B5/00 ,  A61B5/15 ,  A61B17/20 ,  A61K9/70 ,  A61M37/00 ,  A61N1/30 ,  B81C1/00

Abstract: Microneedle devices are provided for transport of molecules across tissue barriers and for use as microflameholders. In a preferred embodiment for transport across tissue, the microneedles are formed of a biodegradable polymer. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver material into or across a biological barrier from chambers in connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.