公开(公告)号：WO2005026137A3

公开(公告)日：2005-07-21

申请号：PCT/US2004029206

申请日：2004-09-07

Applicant: VERTEX PHARMA ,  MILLER MARK T ,  HADIDA RUAH SARA S ,  SINGH ASHAVINI K ,  CLEVELAND THOMAS ,  MAKINGS LEWIS R ,  HAMILTON MATTHEW ,  GROOTENHUIS PETER D J

Inventor： MILLER MARK T ,  HADIDA RUAH SARA S ,  SINGH ASHAVINI K ,  CLEVELAND THOMAS ,  MAKINGS LEWIS R ,  HAMILTON MATTHEW ,  GROOTENHUIS PETER D J

IPC: A61K31/426 ,  A61K31/427 ,  A61P43/00 ,  C07D263/48 ,  C07D277/46 ,  C07D277/82 ,  C07D417/02 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12

CPC classification number: A61K31/426 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/5377 ,  C07D263/48 ,  C07D277/46 ,  C07D277/82 ,  C07D295/15 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  G01N33/5076

Abstract: The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including CF Transmembrane Regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Abstract translation: 本发明涉及ATP结合盒（“ABC”）转运体或其片段的调节剂，包括CF跨膜调节剂（“CFTR”），其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。

公开(公告)号：WO2005035514A2

公开(公告)日：2005-04-21

申请号：PCT/US2004033367

申请日：2004-10-08

Applicant: VERTEX PHARMA ,  HADIDA RUAH SARA S ,  SINGH ASHVANI K ,  MILLER MARK T ,  HAMILTON MATTHEW ,  GROOTENHUIS PETER D J

Inventor： HADIDA RUAH SARA S ,  SINGH ASHVANI K ,  MILLER MARK T ,  HAMILTON MATTHEW ,  GROOTENHUIS PETER D J

IPC: A61K31/00 ,  A61K31/335 ,  A61K31/38 ,  A61K31/40 ,  A61K31/41 ,  A61K31/435 ,  A61K31/495 ,  A61K45/06 ,  C07C233/11 ,  C07C233/22 ,  C07C233/60 ,  C07C233/65 ,  C07C233/73 ,  C07C235/34 ,  C07C235/46 ,  C07C235/48 ,  C07C307/00 ,  C07C311/16 ,  C07C311/17 ,  C07C323/60 ,  C07D209/42 ,  C07D213/82 ,  C07D215/54 ,  C07D215/56 ,  C07D217/26 ,  C07D231/14 ,  C07D231/56 ,  C07D237/28 ,  C07D261/20 ,  C07D307/68 ,  C07D307/85 ,  C07D307/87 ,  C07D333/32 ,  C07D333/70 ,  C07D407/12 ,  C07D307/00

CPC classification number: C07D307/87 ,  A61K31/00 ,  A61K31/335 ,  A61K31/38 ,  A61K31/40 ,  A61K31/41 ,  A61K31/435 ,  A61K31/495 ,  A61K45/06 ,  C07C233/22 ,  C07C233/60 ,  C07C233/65 ,  C07C233/73 ,  C07C235/34 ,  C07C235/46 ,  C07C235/48 ,  C07C311/16 ,  C07C311/17 ,  C07C323/60 ,  C07C2601/08 ,  C07D209/42 ,  C07D213/82 ,  C07D215/54 ,  C07D217/26 ,  C07D231/14 ,  C07D231/56 ,  C07D237/28 ,  C07D261/20 ,  C07D307/68 ,  C07D307/85 ,  C07D333/32 ,  C07D333/70 ,  C07D407/12

Abstract: The present invention provides compounds of Formula (I) useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein R , n, B, R , R , R , A, and Z are described generally and in classes and subclasses below. The present invention also provides pharmaceutical compositions, methods and kits associated with Formula (I), useful for as modulators, and for the treatments of disease and disease conditions associated with ABC transporter proteins.

Abstract translation: 本发明提供可用作ABC转运蛋白活性调节剂的式（I）化合物或其药学上可接受的盐，其中R b，n，B，R c，R d，R e， A和Z一般在下面的类和子类中进行描述。 本发明还提供与式（I）相关的药物组合物，方法和试剂盒，其可用作调节剂，以及用于治疗与ABC转运蛋白相关的疾病和疾病状况。

公开(公告)号：AU2016388305A1

公开(公告)日：2017-08-24

申请号：AU2016388305

申请日：2016-01-20

Applicant: VALDERRABANO VICTOR ,  NUNLEY JAMES ,  DEORIO JAMES ,  EASLEY MARK ,  HAMILTON MATTHEW ,  DIEP PHONG

Inventor： VALDERRABANO VICTOR ,  NUNLEY JAMES ,  DEORIO JAMES ,  EASLEY MARK ,  HAMILTON MATTHEW ,  DIEP PHONG

IPC: A61F2/42

公开(公告)号：AU2008100746A4

公开(公告)日：2008-09-11

申请号：AU2008100746

申请日：2008-08-09

Applicant: HAMILTON MATTHEW ,  HOPE KIRSTI

Inventor： HOPE KIRSTI ,  HAMILTON MATTHEW

IPC: G01B3/02

公开(公告)号：AU2002364547A1

公开(公告)日：2003-11-11

申请号：AU2002364547

申请日：2002-12-09

Applicant: HAMILTON MATTHEW

Inventor： KINNIER ALEX ,  HAMILTON MATTHEW ,  WALTERS RUSSEL

IPC: B05D1/18 ,  B05D5/04 ,  B05D5/06 ,  B41M1/30 ,  B41M1/34 ,  B41M3/00 ,  B32B7/00 ,  G03C11/08

Abstract: It is an object of the present invention to provide novel signs and visual displays produced by different behavior of liquids applied to hydrophilic and hydrophobic surfaces on patterned surfaces. It is also an object of the present invention to provide articles baring logos and alphanumeric text produced by application of liquids to patterned material surfaces. There is further provided a method for producing novel signs and visual displays by producing patterned hydrophobic and hydrophilic surfaces. Also provided are processes for producing patterned surfaces.