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公开(公告)号：AU2016266584B2
公开(公告)日：2020-09-10
申请号：AU2016266584
申请日：2016-03-04
Applicant: HARVARD COLLEGE
Inventor： LEVNER DANIEL , HINOJOSA CHRISTOPHER DAVID , VAN DER MEER ANDRIES , VAN DER HELM MARINKE , JAIN ABHISHEK , INGBER DONALD E , ZAMANI MARJON
Abstract: Systems and methods for measuring dynamic hydraulic conductivity and permeability associated with a cell layer are disclosed. Some systems include a microfluidic device, one or more working-fluid reservoirs, and one or more fluid-resistance element. The microfluidic device includes a first microchannel, a second microchannel, and a barrier therebetween. The barrier includes a cell layer adhered thereto. The working fluids are delivered to the microfluidic device. The fluid-resistance elements are coupled to one or more of the fluid paths and provide fluidic resistance to cause a pressure drop across the fluid-resistance elements. Mass transfer occurs between the first microchannel and the second microchannel, which is indicative of the hydraulic conductivity and/or dynamic permeability associated with the cells.
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2.发明专利
公开(公告)号：AU2014287013B2
公开(公告)日：2020-01-23
申请号：AU2014287013
申请日：2014-07-11
Applicant: HARVARD COLLEGE
Inventor： INGBER DONALD E , LEVNER DANIEL , THOMPSON III GUY , FERNANDEZ-ALCON JOSE , HINOJOSA CHRISTOPHER DAVID
Abstract: Systems and methods interconnect cell culture devices and/or fluidic devices by transferring discrete volumes of fluid between devices. A liquid-handling system collects a volume of fluid from at least one source device and deposits the fluid into at least one destination device. In some embodiments, a liquid-handling robot actuates the movement and operation of a fluid collection device in an automated manner to transfer the fluid between the at least one source device and the at least one destination device. In some cases, the at least one source device and the at least one destination device are cell culture devices. The at least one source device and the at least one destination device may be microfluidic or non-microfluidic devices. In some cases, the cell culture devices may be microfluidic cell culture devices. In further cases, the microfluidic cell culture devices may include organ-chips.
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公开(公告)号：AU2015289999A1
公开(公告)日：2017-03-09
申请号：AU2015289999
申请日：2015-07-10
Applicant: HARVARD COLLEGE
Inventor： HINOJOSA CHRISTOPHER DAVID , SLIZ JOSIAH , THOMPSON GUY , GEISLER HUBERT , FERNANDEZ-ALCON JOSE , INGBER DONALD E , LEVNER DANIEL
Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.
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公开(公告)号：CA2980287A1
公开(公告)日：2016-09-22
申请号：CA2980287
申请日：2016-03-17
Applicant: HARVARD COLLEGE
Inventor： FREAKE JACOB , GOMES JOSH , HINOJOSA CHRISTOPHER DAVID , LEVNER DANIEL , SABIN DOUG , THOMPSON GUY II
Abstract: An incubator assembly includes an incubator enclosure having an internal chamber in which a controlled environment is maintained and which is defined by one or more walls. The incubator assembly further includes a jacket assembly mounted adjacent to at least one of the walls and having an internal airspace in which an internal fluid is enclosed for maintaining a homogenous temperature within the internal chamber. The jacket assembly further has a vent movable between a plurality of positions including an open position in which the internal fluid is allowed to exit the internal airspace into an ambient environment.
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公开(公告)号：WO2014210364A3
公开(公告)日：2015-10-29
申请号：PCT/US2014044417
申请日：2014-06-26
Applicant: HARVARD COLLEGE
Inventor： INGBER DONALD E , HINOJOSA CHRISTOPHER DAVID , LEVNER DANIEL , RESNIKOFF JOSH ISAAC NIELSEN , THOMPSON III GUY
CPC classification number: B01L3/563 , B01J19/0093 , B01J2219/00813 , B01J2219/00988 , B01L3/502715 , B01L2200/025 , B01L2200/027 , B01L2200/04 , B01L2200/0684 , B01L2200/0689 , B01L2200/10 , B01L2200/141 , B01L2300/047 , B01L2300/069 , B01L2300/0861 , B01L2300/0864 , B01L2300/0887 , B01L2300/089 , B01L2300/12 , B01L2300/123 , B01L2300/16 , C12M23/16 , C12M23/40 , C12M29/00
Abstract: An interconnect adaptor for connecting a microfluidic device to a fluidic system. The interconnect adapter includes a base substrate and a nozzle array. The base substrate includes a first side and a second side. The nozzle array includes two or more nozzles extending away from the base substrate. Each nozzle includes an opening with a channel extending therefrom. The channels are configured to transport fluid between the microfluidic device and the fluidic system. Each of the nozzles is configured to be inserted into a respective hole in the microfluidic device. In some embodiments, the insertion forms a radially sealed connection between each nozzle and respective hole when the nozzles are inserted a predetermined distance into the respective holes.
Abstract translation: 用于将微流体装置连接到流体系统的互连适配器。 互连适配器包括基底基板和喷嘴阵列。 基底基板包括第一面和第二面。 喷嘴阵列包括远离基底基板延伸的两个或更多个喷嘴。 每个喷嘴包括具有从其延伸的通道的开口。 通道构造成在微流体装置和流体系统之间输送流体。 每个喷嘴构造成插入到微流体装置中的相应孔中。 在一些实施例中，当喷嘴在相应的孔中插入预定距离时，插入件在每个喷嘴和相应的孔之间形成径向密封的连接。
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Patent Agency Ranking6.发明公开
公开(公告)号：EP3019588A4
公开(公告)日：2017-02-22
申请号：EP14823434
申请日：2014-07-11
Applicant: HARVARD COLLEGE
Inventor： INGBER DONALD E , LEVNER DANIEL , THOMPSON III GUY , FERNANDEZ-ALCON JOSE , HINOJOSA CHRISTOPHER DAVID
CPC classification number: C12M29/10 , B01L3/0293 , B01L3/502715 , B01L2200/027 , B01L2300/0816 , C12M21/08 , C12M23/16 , C12M23/38 , C12M23/58 , C12M29/00 , C12M29/20 , C12M37/04 , C12M41/48
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公开(公告)号：EP3169626A4
公开(公告)日：2018-04-04
申请号：EP15822409
申请日：2015-07-10
Applicant: HARVARD COLLEGE
Inventor： HINOJOSA CHRISTOPHER DAVID , SLIZ JOSIAH , LEVNER DANIEL , THOMPSON GUY , GEISLER HUBERT , FERNANDEZ ALCON JOSE , INGBER DONALD E
CPC classification number: C12M23/16 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L2200/027 , B01L2200/0605 , B01L2200/0684 , B01L2300/044 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/14 , B01L2400/0487 , B01L2400/084 , B82Y15/00 , C12M21/08 , C12M33/12 , C12M41/00 , C12M41/40 , C12M41/46 , G01N33/5005
Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.
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公开(公告)号：CA2980287C
公开(公告)日：2022-08-16
申请号：CA2980287
申请日：2016-03-17
Applicant: HARVARD COLLEGE
Inventor： FREAKE JACOB , GOMES JOSH , HINOJOSA CHRISTOPHER DAVID , LEVNER DANIEL , SABIN DOUG , THOMPSON GUY
Abstract: An incubator assembly includes an incubator enclosure having an internal chamber in which a controlled environment is maintained and which is defined by one or more walls. The incubator assembly further includes a jacket assembly mounted adjacent to at least one of the walls and having an internal airspace in which an internal fluid is enclosed for maintaining a homogenous temperature within the internal chamber. The jacket assembly further has a vent movable between a plurality of positions including an open position in which the internal fluid is allowed to exit the internal airspace into an ambient environment.
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公开(公告)号：WO2014133624A3
公开(公告)日：2014-11-13
申请号：PCT/US2013074123
申请日：2013-12-10
Applicant: HARVARD COLLEGE
Inventor： THOMPSON GUY , LEVNER DANIEL , HINOJOSA CHRISTOPHER DAVID
IPC: G05D7/00
CPC classification number: B01L3/50273 , B01L2200/025 , B01L2200/027 , B01L2200/10 , B01L2300/0848 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , B01L2400/082 , F04B19/006 , F04B43/12
Abstract: Described herein are fluid-flow control devices for transferring a fluid from a place to another and/or controlling a fluid flow. In some embodiments, fluid-flow control devices described herein can be used as pumping devices to transfer a fluid by peristaltic motion and/or as valve devices to control fluid flow for various applications, e.g., in a microfluidic platform.
Abstract translation: 这里描述的是用于将流体从一个地方转移到另一个地方和/或控制流体流动的流体流动控制装置。 在一些实施例中，本文描述的流体流量控制装置可以用作泵送装置以通过蠕动运动传送流体和/或用作阀装置以控制用于各种应用的流体流动，例如在微流体平台中。
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公开(公告)号：EP3024582A4
公开(公告)日：2017-03-08
申请号：EP14829645
申请日：2014-07-22
Applicant: HARVARD COLLEGE
Inventor： INGBER DONALD E , LEVNER DANIEL , THOMPSON GUY II , HINOJOSA CHRISTOPHER DAVID
IPC: B01L3/00
CPC classification number: B01L3/502715 , B01L3/502707 , B01L3/56 , B01L2200/027 , B01L2200/0684 , B01L2200/0689 , B01L2200/12 , B01L2300/0645 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0655
Abstract: According to aspects of the present invention, a cartridge assembly for transporting fluid into or out of one or more fluidic devices includes a first layer and a second layer. The first layer includes a first surface. The first surface includes at least one partial channel disposed thereon. The second layer abuts the first surface, thereby forming a channel from the at least one partial channel. At least one of the first layer and the second layer is a resilient layer formed from a pliable material. At least one of the first layer and the second layer includes a via hole. The via hole is aligned with the channel to pass fluid thereto. The via hole is configured to pass fluid through the first layer or the second layer substantially perpendicularly to the channel. Embossments are also used to define aspects of a fluidic channel.
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