公开(公告)号：AT555836T

公开(公告)日：2012-05-15

申请号：AT08826080

申请日：2008-06-30

Applicant: HARVARD COLLEGE

Inventor： PHILLIPS SCOTT ,  WHITESIDES GEORGE M ,  MIRICA KATHERINE ,  CARRILHO EMANUEL ,  MARTINEZ ANDRES ,  SHEVKOPLYAS SERGEY ,  SNYDER PHILLIP ,  PEREZ-CASTILLEJOS RAQUEL ,  GUPTA MALANCHA ,  WINKLEMAN ADAM ,  GUDIKSEN KATHERINE

IPC: B01D35/06 ,  B01L3/00

公开(公告)号：WO2008051432A3

公开(公告)日：2009-04-09

申请号：PCT/US2007022219

申请日：2007-10-18

Applicant: HARVARD COLLEGE ,  LAHAV MICHAL ,  WINKLEMAN ADAM ,  NAROVLYANSKY MAX ,  PEREZ-CASTILLEJOS RAQUEL ,  WEISS EMILY A ,  RODRIGUEZ LEONARD N J ,  WHITESIDES GEORGE M

Inventor： LAHAV MICHAL ,  WINKLEMAN ADAM ,  NAROVLYANSKY MAX ,  PEREZ-CASTILLEJOS RAQUEL ,  WEISS EMILY A ,  RODRIGUEZ LEONARD N J ,  WHITESIDES GEORGE M

IPC: G03F7/00

CPC classification number: G03F7/0002 ,  B82Y10/00 ,  B82Y40/00 ,  Y10T428/24479

Abstract: In one aspect, methods of patterning of thin films of an ionotropic polymer (e.g., poly(acrylic acid)) are provided. These processes can create micron or sub-micron-scale patterns of ionotropic polymers such as cation crosslinked poly(acrylic acid) (CCL- PAA). In one embodiment, patterning may be performed within microfluidic channels by flowing a solution of crosslinking agent (e.g., metal cations such as Ag+, Ca2+, Pd2+, Al3+, La3+, and Ti4+) that can crosslink a portion of an ionotropic polymer in contact with the solution. In another embodiment, methods of patterning ionotropic polymers involve photolithography. Upon patterning a positive photoresist (e.g., diazonaphthoquinone- novolac resin) on a film of CCL-PAA, the exposed regions of CCL-PAA can be etched by an aqueous solution. Advantageously, the patterned, crosslinked polymer may also serve as both a reactant and a matrix for subsequent chemistry. For example, in some embodiments, the initial crosslinking cation can be exchanged for a second cation that could not be patterned photolithographically. Patterned films of CCL-PAA can also be used to host and template the reduction of metallic cations to metallic nanoparticles, and to fabricate porous, low-k dielectric substrates.

Abstract translation: 一方面，提供了离子型聚合物（例如聚（丙烯酸））的薄膜图案化方法。 这些方法可以产生离子型聚合物如阳离子交联的聚（丙烯酸）（CCL-PAA）的微米级或亚微米级的图案。 在一个实施方案中，可以在微流体通道内通过使交联剂（例如金属阳离子如Ag +，Ca 2+，Pd 2+，Al 3+，La 3+和Ti 4+）的溶液流过微流体通道，所述溶液可以将部分离子型聚合物与 解决方案。 在另一个实施方案中，构图离子型聚合物的方法涉及光刻。 在CCL-PAA膜上形成正性光致抗蚀剂（例如重氮萘酚 - 酚醛清漆树脂）之后，CCL-PAA的曝光区域可以通过水溶液进行蚀刻。 有利地，图案化的交联聚合物也可以用作反应物和用于后续化学的基质。 例如，在一些实施方案中，可以将初始交联阳离子交换为不能光刻图案化的第二阳离子。 CCL-PAA的图案化膜也可用于将金属阳离子还原为金属纳米颗粒，并制备多孔，低k电介质基底。

公开(公告)号：EP2167216A4

公开(公告)日：2011-03-09

申请号：EP08826080

申请日：2008-06-30

Applicant: HARVARD COLLEGE

Inventor： PHILLIPS SCOTT T ,  WHITESIDES GEORGE M ,  MIRICA KATHERINE A ,  CARRILHO EMANUEL ,  MARTINEZ ANDRES W ,  SHEVKOPLYAS SERGEY S ,  SNYDER PHILLIP W ,  PEREZ-CASTILLEJOS RAQUEL ,  GUPTA MALANCHA ,  WINKLEMAN ADAM ,  GUDIKSEN KATHERINE L

IPC: B01D35/06 ,  B01L3/00

CPC classification number: G01N33/5434 ,  B01L3/502761 ,  B01L3/502776 ,  B01L3/50825 ,  B01L2200/0652 ,  B01L2300/045 ,  B01L2300/0877 ,  B01L2300/089 ,  B01L2400/043 ,  B01L2400/0457 ,  B01L2400/0487 ,  G01N33/54333 ,  G01R33/1269

公开(公告)号：WO2009006409A2

公开(公告)日：2009-01-08

申请号：PCT/US2008068797

申请日：2008-06-30

Applicant: HARVARD COLLEGE ,  PHILLIPS SCOTT T ,  WHITESIDES GEORGE M ,  MIRICA KATHERINE A ,  CARRILHO EMANUEL ,  MARTINEZ ANDRES W ,  SHEVKOPLYAS SERGEY S ,  SNYDER PHILLIP W ,  PEREZ-CASTILLEJOS RAQUEL ,  GUPTA MALANCHA ,  WINKLEMAN ADAM ,  GUDIKSEN KATHERINE L

Inventor： PHILLIPS SCOTT T ,  WHITESIDES GEORGE M ,  MIRICA KATHERINE A ,  CARRILHO EMANUEL ,  MARTINEZ ANDRES W ,  SHEVKOPLYAS SERGEY S ,  SNYDER PHILLIP W ,  PEREZ-CASTILLEJOS RAQUEL ,  GUPTA MALANCHA ,  WINKLEMAN ADAM ,  GUDIKSEN KATHERINE L

IPC: G01N33/53

CPC classification number: G01N33/5434 ,  B01L3/502761 ,  B01L3/502776 ,  B01L3/50825 ,  B01L2200/0652 ,  B01L2300/045 ,  B01L2300/0877 ,  B01L2300/089 ,  B01L2400/043 ,  B01L2400/0457 ,  B01L2400/0487 ,  G01N33/54333 ,  G01R33/1269

Abstract: The ability to levitate, to separate, and to detect changes in density using diamagnetic particles suspended in solutions containing paramagnetic cations using an inhomogeneous magnetic field is described. The major advantages of this separation device are that: i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) it is compatible with simple optical detection (provided that transparent materials are used to fabricate the containers/channels where separation occurs; iii) it is simple to collect the separated particles for further processing; iv) it does not require magnetic labeling of the particles/materials; and v) it is small, portable. The method and kits provided provide for separation and collection of materials of different densities, diagnostics for detection of analytes of interest, monitoring of solid-supported chemical reactions and determination of densities of solid and liquid mixtures.

Abstract translation: 描述了悬浮在使用不均匀磁场的含有顺磁性阳离子的溶液中的反磁性粒子悬浮，分离和检测密度变化的能力。 该分离装置的主要优点是：i）它是一种不需要电力的简单装置（一组永磁体和重力足以使抗磁分离和收集系统工作）; ii）它与简单的光学检测兼容（只要透明材料用于制造分离发生的容器/通道; iii）收集分离的颗粒以便进一步处理是简单的; iv）它不需要磁性标记颗粒/材料; 和v）它小巧便携。 所提供的方法和试剂盒用于分离和收集不同密度的物质，用于检测感兴趣分析物的诊断，固体支持的化学反应的监测以及固体和液体混合物密度的测定。