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    COTTON THREAD AS A LOW-COST MULTI-ASSAY DIAGNOSTIC PLATFORM
    1.
    发明专利
    COTTON THREAD AS A LOW-COST MULTI-ASSAY DIAGNOSTIC PLATFORM 未知

    公开(公告)号：CA2719322C

    公开(公告)日：2018-11-27

    申请号：CA2719322

    申请日：2009-03-27

    Applicant: HARVARD COLLEGE

    Inventor： RECHES MEITAL ,  DICKEY MICHAEL D ,  BUTTE MANISH J ,  WHITESIDES GEORGE M

    IPC: G01N35/00 ,  G01N33/48 ,  G01N33/49 ,  G01N33/493 ,  G01N33/50

    Abstract: Hydrophilic threads as platforms for inexpensive, low volume, portable diagnostic systems, and methods of making the same are described. A diagnostic system includes a hydrophilic loading thread having an inlet zone at a proximal end; a testing zone at a distal end; and an intermediate zone located between the inlet zone and the testing zone, wherein the testing zone does not directly contact the inlet zone. In another aspect, a diagnostic system includes (i) a hydrophilic loading thread that includes an inlet zone at a proximal end and an intermediate zone at a distal end; and (ii) one or more additional hydrophilic threads that contact the intermediate zone of the loading thread. A method of detecting the presence or absence of an analyte in a fluid sample includes applying the sample to an inlet zone of a diagnostic system that includes a hydrophilic loading thread with an inlet zone at a proximal end; an intermediate zone; and a testing zone at a distal end; wherein the testing zone does not directly contact the inlet zone.

    SYSTEMS AND METHODS FOR ASSEMBLY VIA CONTACT ELECTRIFICATION
    5.
    发明申请
    SYSTEMS AND METHODS FOR ASSEMBLY VIA CONTACT ELECTRIFICATION 审中-公开
    通过接触电气组装的系统和方法

    公开(公告)号：WO2008127649A3

    公开(公告)日：2009-06-04

    申请号：PCT/US2008004704

    申请日：2008-04-11

    Applicant: HARVARD COLLEGE ,  WHITESIDES GEORGE M ,  MCCARTY LOGAN S ,  THOMAS SAMUEL W ,  RECHES MEITAL ,  KAUFMAN GEORGE K

    Inventor： WHITESIDES GEORGE M ,  MCCARTY LOGAN S ,  THOMAS SAMUEL W ,  RECHES MEITAL ,  KAUFMAN GEORGE K

    IPC: C08J5/12 ,  B05D1/04 ,  C08J7/00

    CPC classification number: C08J5/12 ,  B05D3/14 ,  B05D7/02 ,  B05D2401/32 ,  C08J7/047 ,  C08J2327/18 ,  C08J2433/12

    Abstract: The present invention generally relates to the charging of materials via contact electrification, including systems and methods of assembly using contact electrification. One aspect of the present invention is directed to systems and methods of identifying and synthesizing nonionic polymeric materials that can be charged using contact electrification. Another aspect of the present invention is directed to methods of localizing charged particles or other materials on such surfaces, for example, in the presence of a controlled humidity environment. Yet another aspect of the present invention is directed to a surface comprising positively and negatively charged regions. Oppositely charged materials may be attracted to those regions. Other aspects of the invention are directed to methods of making, using, and promoting such materials, or kits containing such materials.

    Abstract translation: 本发明一般涉及通过接触带电充电材料，包括使用接触带电装配的系统和组装方法。 本发明的一个方面涉及鉴定和合成可以使用接触带电充电的非离子聚合物材料的系统和方法。 本发明的另一方面涉及将带电粒子或其它材料定位在这些表面上的方法，例如在受控湿度环境的存在下。 本发明的另一方面涉及包括正带电和带负电荷的区域的表面。 对这些区域可能会吸引相反电荷的材料。 本发明的其它方面涉及制造，使用和促进这些材料或包含这种材料的试剂盒的方法。

    COTTON THREAD AS A LOW-COST MULTI-ASSAY DIAGNOSTIC PLATFORM
    6.
    发明申请
    COTTON THREAD AS A LOW-COST MULTI-ASSAY DIAGNOSTIC PLATFORM 审中-公开
    棉线作为低成本多测量诊断平台

    公开(公告)号：WO2009121043A3

    公开(公告)日：2010-01-07

    申请号：PCT/US2009038702

    申请日：2009-03-27

    Applicant: HARVARD COLLEGE ,  RECHES MEITAL ,  DICKEY MICHAEL D ,  BUTTE MANISH J ,  WHITESIDES GEORGE M

    Inventor： RECHES MEITAL ,  DICKEY MICHAEL D ,  BUTTE MANISH J ,  WHITESIDES GEORGE M

    IPC: G01N35/00 ,  G01N33/48 ,  G01N33/49 ,  G01N33/493 ,  G01N33/50

    CPC classification number: B01L3/5023 ,  B01L3/5088 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2300/0825 ,  B01L2300/0845 ,  B01L2300/087 ,  B01L2300/12 ,  B01L2300/161 ,  B01L2400/0406 ,  G01N33/54386

    Abstract: Hydrophilic threads as platforms for inexpensive, low volume, portable diagnostic systems, and methods of making the same are described. A diagnostic system includes a hydrophilic loading thread having an inlet zone at a proximal end; a testing zone at a distal end; and an intermediate zone located between the inlet zone and the testing zone, wherein the testing zone does not directly contact the inlet zone. In another aspect, a diagnostic system includes (i) a hydrophilic loading thread that includes an inlet zone at a proximal end and an intermediate zone at a distal end; and (ii) one or more additional hydrophilic threads that contact the intermediate zone of the loading thread. A method of detecting the presence or absence of an analyte in a fluid sample includes applying the sample to an inlet zone of a diagnostic system that includes a hydrophilic loading thread with an inlet zone at a proximal end; an intermediate zone; and a testing zone at a distal end; wherein the testing zone does not directly contact the inlet zone.

    Abstract translation: 描述了作为廉价，低容量，便携式诊断系统的平台的亲水丝线及其制造方法。 诊断系统包括在近端具有入口区域的亲水加载螺纹; 远端的测试区; 以及位于入口区域和测试区域之间的中间区域，其中测试区域不直接接触入口区域。 在另一方面，诊断系统包括（i）亲水加载线，其包括在近端处的入口区域和在远端处的中间区域; 和（ii）接触加载螺纹的中间区域的一个或多个附加亲水丝线。 检测流体样品中分析物的存在或不存在的方法包括将样品施加到诊断系统的入口区域，诊断系统的入口区域包括具有近端的入口区域的亲水加载螺纹; 中间区 和远端的测试区; 其中所述测试区域不直接接触所述入口区域。

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