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    COTTON THREAD AS A LOW-COST MULTI-ASSAY DIAGNOSTIC PLATFORM
    2.
    发明专利
    COTTON THREAD AS A LOW-COST MULTI-ASSAY DIAGNOSTIC PLATFORM 未知

    公开(公告)号：CA2719322C

    公开(公告)日：2018-11-27

    申请号：CA2719322

    申请日：2009-03-27

    Applicant: HARVARD COLLEGE

    Inventor： RECHES MEITAL ,  DICKEY MICHAEL D ,  BUTTE MANISH J ,  WHITESIDES GEORGE M

    IPC: G01N35/00 ,  G01N33/48 ,  G01N33/49 ,  G01N33/493 ,  G01N33/50

    Abstract: Hydrophilic threads as platforms for inexpensive, low volume, portable diagnostic systems, and methods of making the same are described. A diagnostic system includes a hydrophilic loading thread having an inlet zone at a proximal end; a testing zone at a distal end; and an intermediate zone located between the inlet zone and the testing zone, wherein the testing zone does not directly contact the inlet zone. In another aspect, a diagnostic system includes (i) a hydrophilic loading thread that includes an inlet zone at a proximal end and an intermediate zone at a distal end; and (ii) one or more additional hydrophilic threads that contact the intermediate zone of the loading thread. A method of detecting the presence or absence of an analyte in a fluid sample includes applying the sample to an inlet zone of a diagnostic system that includes a hydrophilic loading thread with an inlet zone at a proximal end; an intermediate zone; and a testing zone at a distal end; wherein the testing zone does not directly contact the inlet zone.

    PAPER-BASED MICROFLUIDIC SYSTEMS
    4.
    发明专利
    PAPER-BASED MICROFLUIDIC SYSTEMS 未知

    公开(公告)号：CA2719800A1

    公开(公告)日：2009-10-01

    申请号：CA2719800

    申请日：2009-03-27

    Applicant: HARVARD COLLEGE

    Inventor： SIEGEL ADAM C ,  PHILLIPS SCOTT T ,  DICKEY MICHAEL D ,  ROZKIEWICZ DOROTA ,  WILEY BENJAMIN ,  WHITESIDES GEORGE M ,  MARTINEZ ANDRES W

    IPC: G01N35/00 ,  G01N27/26 ,  G01N33/48

    Abstract: The invention features an assay device, a microfluidic device, and a method of detecting the presence of high electrolyte concentration in a fluid sample. The assay device comprises a porous, hydrophilic substrate; a fluid-impermeable barrier defining a boundary of an assay region and a boundary of a main channel region, the main channel region fluidically connected to the assay region; and a strip of conductive material disposed on the porous, hydrophilic substrate. The microfluidic device comprises a porous, hydrophilic substrate; a fluid-impermeable barrier, the barrier permeating the thickness of the porous, hydrophilic substrate and defining within the porous, hydrophilic substrate a boundary of an open-ended channel having first and second lateral walls; and an electrically conductive pathway disposed on the porous, hydrophilic substrate, the electrically conductive pathway comprising (i) a strip of conductive material forming an open circuit in the absence of an electrically conductive material bridging the first and second lateral walls; and (ii) a battery, an electrically-responsive indicator, and a resistor electrically connected to the strip of conductive material.

    PAPER-BASED MICROFLUIDIC SYSTEMS
    7.
    发明申请
    PAPER-BASED MICROFLUIDIC SYSTEMS 审中-公开
    基于纸张的微流体系统

    公开(公告)号：WO2009121041A3

    公开(公告)日：2009-12-17

    申请号：PCT/US2009038699

    申请日：2009-03-27

    Applicant: HARVARD COLLEGE ,  SIEGEL ADAM C ,  PHILLIPS SCOTT T ,  DICKEY MICHAEL D ,  ROZKIEWICZ DOROTA ,  WILEY BENJAMIN ,  WHITESIDES GEORGE M ,  MARTINEZ ANDRES W

    Inventor： SIEGEL ADAM C ,  PHILLIPS SCOTT T ,  DICKEY MICHAEL D ,  ROZKIEWICZ DOROTA ,  WILEY BENJAMIN ,  WHITESIDES GEORGE M ,  MARTINEZ ANDRES W

    IPC: G01N35/00 ,  G01N27/26 ,  G01N33/48

    CPC classification number: B01L3/502707 ,  B01L2200/027 ,  B01L2200/0642 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2300/025 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0809 ,  B01L2300/0819 ,  B01L2300/087 ,  B01L2300/12 ,  B01L2300/126 ,  B01L2300/161 ,  B01L2300/1827 ,  B01L2400/0406 ,  Y10T436/25 ,  Y10T436/2575

    Abstract: The invention features an assay device, a microfluidic device, and a method of detecting the presence of high electrolyte concentration in a fluid sample. The assay device comprises a porous, hydrophilic substrate; a fluid-impermeable barrier defining a boundary of an assay region and a boundary of a main channel region, the main channel region fluidically connected to the assay region; and a strip of conductive material disposed on the porous, hydrophilic substrate. The microfluidic device comprises a porous, hydrophilic substrate; a fluid-impermeable barrier, the barrier permeating the thickness of the porous, hydrophilic substrate and defining within the porous, hydrophilic substrate a boundary of an open-ended channel having first and second lateral walls; and an electrically conductive pathway disposed on the porous, hydrophilic substrate, the electrically conductive pathway comprising (i) a strip of conductive material forming an open circuit in the absence of an electrically conductive material bridging the first and second lateral walls; and (ii) a battery, an electrically-responsive indicator, and a resistor electrically connected to the strip of conductive material.

    Abstract translation: 本发明的特征在于测定装置，微流体装置和检测流体样品中高电解质浓度的存在的方法。 测定装置包括多孔亲水底物; 限定测定区域和主通道区域边界的流体不渗透屏障，主通道区域与流体连接到测定区域的主通道区域; 以及设置在多孔亲水基底上的导电材料条。 微流体装置包括多孔的亲水基底; 流体不可渗透的屏障，所述屏障渗透所述多孔亲水基底的厚度，并且在所述多孔亲水基底内限定具有第一和第二侧壁的开放式通道的边界; 以及设置在所述多孔亲水基底上的导电通路，所述导电路径包括（i）在桥接所述第一和第二侧壁的导电材料不存在的情况下形成开路的导电材料条; 以及（ii）电池，电响应指示器和电连接到导电材料条的电阻器。

    COTTON THREAD AS A LOW-COST MULTI-ASSAY DIAGNOSTIC PLATFORM
    9.
    发明申请
    COTTON THREAD AS A LOW-COST MULTI-ASSAY DIAGNOSTIC PLATFORM 审中-公开
    棉线作为低成本多测量诊断平台

    公开(公告)号：WO2009121043A3

    公开(公告)日：2010-01-07

    申请号：PCT/US2009038702

    申请日：2009-03-27

    Applicant: HARVARD COLLEGE ,  RECHES MEITAL ,  DICKEY MICHAEL D ,  BUTTE MANISH J ,  WHITESIDES GEORGE M

    Inventor： RECHES MEITAL ,  DICKEY MICHAEL D ,  BUTTE MANISH J ,  WHITESIDES GEORGE M

    IPC: G01N35/00 ,  G01N33/48 ,  G01N33/49 ,  G01N33/493 ,  G01N33/50

    CPC classification number: B01L3/5023 ,  B01L3/5088 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2300/0825 ,  B01L2300/0845 ,  B01L2300/087 ,  B01L2300/12 ,  B01L2300/161 ,  B01L2400/0406 ,  G01N33/54386

    Abstract: Hydrophilic threads as platforms for inexpensive, low volume, portable diagnostic systems, and methods of making the same are described. A diagnostic system includes a hydrophilic loading thread having an inlet zone at a proximal end; a testing zone at a distal end; and an intermediate zone located between the inlet zone and the testing zone, wherein the testing zone does not directly contact the inlet zone. In another aspect, a diagnostic system includes (i) a hydrophilic loading thread that includes an inlet zone at a proximal end and an intermediate zone at a distal end; and (ii) one or more additional hydrophilic threads that contact the intermediate zone of the loading thread. A method of detecting the presence or absence of an analyte in a fluid sample includes applying the sample to an inlet zone of a diagnostic system that includes a hydrophilic loading thread with an inlet zone at a proximal end; an intermediate zone; and a testing zone at a distal end; wherein the testing zone does not directly contact the inlet zone.

    Abstract translation: 描述了作为廉价，低容量，便携式诊断系统的平台的亲水丝线及其制造方法。 诊断系统包括在近端具有入口区域的亲水加载螺纹; 远端的测试区; 以及位于入口区域和测试区域之间的中间区域，其中测试区域不直接接触入口区域。 在另一方面，诊断系统包括（i）亲水加载线，其包括在近端处的入口区域和在远端处的中间区域; 和（ii）接触加载螺纹的中间区域的一个或多个附加亲水丝线。 检测流体样品中分析物的存在或不存在的方法包括将样品施加到诊断系统的入口区域，诊断系统的入口区域包括具有近端的入口区域的亲水加载螺纹; 中间区 和远端的测试区; 其中所述测试区域不直接接触所述入口区域。

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