公开(公告)号：CA2865744A1

公开(公告)日：2013-09-06

申请号：CA2865744

申请日：2013-02-28

Applicant: HARVARD COLLEGE

Inventor： SUPER MICHAEL ,  INGBER DONALD E ,  CARTWRIGHT MARK J ,  WATTERS ALEXANDER ,  WORKMAN JOHN SAMUEL ,  LEVNER DANIEL ,  ROTTMAN MARTIN

IPC: C12Q1/18 ,  C12Q1/02 ,  C12Q1/04

Abstract: Embodiments of various aspects described herein are directed to methods, compositions, kits and systems for rapid determination of antibiotic susceptibility of a microbe within hours after a sample is collected. In some embodiments, the methods, compositions, kits and systems described herein can allow determination of antibiotic susceptibility of a microbe based on a small number of microbes, e.g., as few as 5-10 microbes bound to a microbe-targeting substrate described herein.

公开(公告)号：HK1206066A1

公开(公告)日：2015-12-31

申请号：HK15106373

申请日：2015-07-03

Applicant: HARVARD COLLEGE

Inventor： SUPER MICHAEL ,  INGBER DONALD E ,  CARTWRIGHT MARK J ,  WATTERS ALEXANDER ,  WORKMAN JOHN SAMUEL ,  LEVNER DANIEL ,  ROTTMAN MARTIN

IPC: C12Q20060101

Abstract: Embodiments of various aspects described herein are directed to methods, compositions, kits and systems for rapid determination of antibiotic susceptibility of a microbe within hours after a sample is collected. In some embodiments, the methods, compositions, kits and systems described herein can allow determination of antibiotic susceptibility of a microbe based on a small number of microbes, e.g., as few as 5-10 microbes bound to a microbe-targeting substrate described herein.

公开(公告)号：AU2013225823A1

公开(公告)日：2014-09-18

申请号：AU2013225823

申请日：2013-02-28

Applicant: HARVARD COLLEGE

Inventor： SUPER MICHAEL ,  INGBER DONALD E ,  CARTWRIGHT MARK J ,  WATTERS ALEXANDER ,  WORKMAN JOHN SAMUEL ,  LEVNER DANIEL ,  ROTTMAN MARTIN

IPC: C12Q1/18 ,  C12Q1/02 ,  C12Q1/04

Abstract: Embodiments of various aspects described herein are directed to methods, compositions, kits and systems for rapid determination of antibiotic susceptibility of a microbe within hours after a sample is collected. In some embodiments, the methods, compositions, kits and systems described herein can allow determination of antibiotic susceptibility of a microbe based on a small number of microbes, e.g., as few as 5-10 microbes bound to a microbe-targeting substrate described herein.

公开(公告)号：WO2015095604A3

公开(公告)日：2015-11-12

申请号：PCT/US2014071293

申请日：2014-12-18

Applicant: HARVARD COLLEGE ,  WATTERS ALEXANDER ,  INGBER DONALD ,  CARTWRIGHT MARK ,  SUPER MICHAEL ,  ROTTMAN MARTIN

Inventor： WATTERS ALEXANDER ,  INGBER DONALD ,  CARTWRIGHT MARK ,  SUPER MICHAEL ,  ROTTMAN MARTIN ,  MURRAY EVANGELINA

IPC: C07K1/00 ,  C07H21/04 ,  C07K16/00 ,  C12P21/04 ,  C12P21/06

CPC classification number: C07K14/4737 ,  A61K38/00 ,  A61K47/42 ,  C07K14/4726 ,  C07K2319/30 ,  C07K2319/33 ,  G01N33/569 ,  G01N33/56911 ,  G01N33/56916 ,  G01N33/56938 ,  G01N33/56944 ,  G01N2333/4737

Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.

Abstract translation: 本文描述了工程化的微生物靶向分子，微生物靶向制品，包含其的试剂盒及其用途。 这样的微生物靶向分子，微生物靶向制品或包含其的试剂盒可以结合或捕获其微生物或微生物物质，因此可以用于各种应用中，例如诊断或治疗由微生物引起的感染 主题或任何环境表面。

公开(公告)号：WO2015009734A2

公开(公告)日：2015-01-22

申请号：PCT/US2014046716

申请日：2014-07-15

Applicant: HARVARD COLLEGE

Inventor： CARTWRIGHT MARK J ,  GAMINI NAZITA ,  INGBER DONALD E ,  ROTTMAN MARTIN ,  SUPER MICHAEL ,  TOMOLONIS JULIE A ,  SINCLAIR KAREN A

IPC: C12Q1/18

CPC classification number: G01N33/56911 ,  C12Q1/18 ,  G01N33/5695 ,  G01N33/56961 ,  G01N2333/4724 ,  G01N2400/00 ,  G01N2800/26 ,  G01N2800/52

Abstract: The disclosure provides methods, compositions, and kits for enhanced detection of microbes in samples and monitoring of antimicrobial activity in a subject.

Abstract translation: 本公开提供用于增强样品中微生物检测和监测受试者中抗微生物活性的方法，组合物和试剂盒。

公开(公告)号：EP3022314A4

公开(公告)日：2017-06-28

申请号：EP14826043

申请日：2014-07-15

Applicant: HARVARD COLLEGE

Inventor： CARTWRIGHT MARK J ,  GAMINI NAZITA ,  INGBER DONALD E ,  ROTTMAN MARTIN ,  SUPER MICHAEL ,  TOMOLONIS JULIE A ,  SINCLAIR KAREN A

IPC: C12Q1/18 ,  G01N33/569

CPC classification number: G01N33/56911 ,  C12Q1/18 ,  G01N33/5695 ,  G01N33/56961 ,  G01N2333/4724 ,  G01N2400/00 ,  G01N2800/26 ,  G01N2800/52

Abstract: The disclosure provides methods, compositions, and kits for enhanced detection of microbes in samples and monitoring of antimicrobial activity in a subject.

Abstract translation: 本公开内容提供用于增强检测样品中的微生物和监测受试者的抗微生物活性的方法，组合物和试剂盒。

公开(公告)号：EP3083658A4

公开(公告)日：2017-07-12

申请号：EP14872439

申请日：2014-12-18

Applicant: HARVARD COLLEGE

Inventor： WATTERS ALEXANDER ,  INGBER DONALD ,  CARTWRIGHT MARK ,  SUPER MICHAEL ,  ROTTMAN MARTIN ,  MURRAY EVANGELINA ,  DUSEL BRENDON

IPC: C07K1/00 ,  C07H21/04 ,  C07K16/00 ,  C12P21/04 ,  C12P21/06

CPC classification number: C07K14/4737 ,  A61K38/00 ,  A61K47/42 ,  C07K14/4726 ,  C07K2319/30 ,  C07K2319/33 ,  G01N33/569 ,  G01N33/56911 ,  G01N33/56916 ,  G01N33/56938 ,  G01N33/56944 ,  G01N2333/4737

Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.

Abstract translation: 本文描述了经改造的微生物靶向分子，微生物靶向制品，包含其的试剂盒及其用途。 这样的微生物靶向分子，微生物靶向制品或包含它们的试剂盒可以结合或捕获其微生物或微生物，并因此可以用于各种应用，例如诊断或治疗由微生物 主题或任何环境表面。

公开(公告)号：EP2820147A4

公开(公告)日：2015-10-14

申请号：EP13755202

申请日：2013-02-28

Applicant: HARVARD COLLEGE

Inventor： SUPER MICHAEL ,  INGBER DONALD E ,  CARTWRIGHT MARK J ,  WATTERS ALEXANDER ,  WORKMAN JOHN SAMUEL ,  LEVNER DANIEL ,  ROTTMAN MARTIN

IPC: C12Q1/18 ,  G01N33/569

CPC classification number: G01N33/56938 ,  C12Q1/18 ,  G01N33/56911 ,  G01N33/56916 ,  G01N2333/245 ,  G01N2333/31 ,  G01N2500/10

Abstract: Embodiments of various aspects described herein are directed to methods, compositions, kits and systems for rapid determination of antibiotic susceptibility of a microbe within hours after a sample is collected. In some embodiments, the methods, compositions, kits and systems described herein can allow determination of antibiotic susceptibility of a microbe based on a small number of microbes, e.g., as few as 5-10 microbes bound to a microbe-targeting substrate described herein.

Abstract translation: 本文描述的各个方面的实施方案涉及用于在收集样品后几小时内快速测定微生物的抗生素敏感性的方法，组合物，试剂盒和系统。 在一些实施方案中，本文所述的方法，组合物，试剂盒和系统可以允许基于少量微生物测定微生物的抗生素敏感性，例如与本文所述的微生物靶向底物结合的少至5-10个微生物。