公开(公告)号：WO2021257069A1

公开(公告)日：2021-12-23

申请号：PCT/US2020/038156

申请日：2020-06-17

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： NIELSEN, Jeffrey A. ,  SHKOLNIKOV, Viktor ,  MIDTTVEIT, Erica ,  PUGLIESE, Roberto A. ,  SMITH, Matthew D. ,  DAY, Michael J. ,  HAMMERSTAD, Diane R.

IPC: B01L3/00 ,  B81B1/00

Abstract: A method of detecting passage of a particle into a target location includes receiving a sample on a die including a microfluidic chamber, the microfluidic chamber including a microfluidic path coupling a reservoir to a foyer, and moving the sample from the reservoir to the foyer by firing a nozzle fluidically coupled to the foyer. The method further includes detecting passage of a particle of the sample from the reservoir to the foyer via a first sensor disposed within the microfluidic path, and detecting passage of the particle into the target location via a second sensor disposed between the first sensor and the nozzle. The method includes recording in a dispense map, an indication of whether the target location includes a single particle or multiple particles based on signals measured by the first sensor and the second sensor.

公开(公告)号：WO2021257068A1

公开(公告)日：2021-12-23

申请号：PCT/US2020/038154

申请日：2020-06-17

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： NIELSEN, Jeffrey, A. ,  MIDTTVEIT, Erica ,  CYR, Kathryn

IPC: B01L3/00 ,  B81B1/00

Abstract: A method of determining an error in detected passage of a target particle population into a target location includes receiving a sample on a die including a microfluidic chamber, the microfluidic chamber including a microfluidic path coupling a reservoir to a foyer, and moving the sample from the reservoir to the foyer by firing a nozzle fluidically coupled to the foyer. The method further includes detecting passage of a target particle population of the sample to the foyer and into a target location of a substrate via a first sensor located proximate to the foyer, and determining an error in the detected passage of the target particle population into the target location of the substrate based on a signal received from the first sensor. In response to the determination, the method includes classifying the target location as erroneous.