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公开(公告)号：WO2020159537A1
公开(公告)日：2020-08-06
申请号：PCT/US2019/016321
申请日：2019-02-01
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： GOVYADINOV, Alexander , SHKOLNIKOV, Viktor , HAMMERSTAD, Diane R.
Abstract: In one example in accordance with the present disclosure, a cellular analytic system is described. The cellular analytic system includes an analytic device. The analytic device includes a chamber to receive a cell to be analyzed. At least one lysing element agitates the cell and at least one sensor detects a change in the cell based on an agitation of the cell. The cellular analytic system also includes a controller to determine a rupture threshold of the cell based on parameters of the agitation when a cell membrane ruptures.
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公开(公告)号：WO2019236053A1
公开(公告)日：2019-12-12
申请号：PCT/US2018/035887
申请日：2018-06-04
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： NIELSEN, Jeffrey A. , DUDENHOEFER, Christie , THOMAS, Debora J. , PUGLIESE, Roberto A. , HAMMERSTAD, Diane R.
Abstract: In one example in accordance with the present disclosure, a fluidic die is described. The fluidic die includes a plurality of ejection subassemblies. Each ejection subassembly includes an ejection chamber to hold a volume of fluid and an opening through which the volume of fluid is ejected via a fluid actuator. A pitch of the ejection subassemblies aligns with a spatial arrangement of nanowells in an array of nanowel!s on a substrate.
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公开(公告)号：WO2021262191A1
公开(公告)日：2021-12-30
申请号：PCT/US2020/039789
申请日：2020-06-26
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： PUGLIESE, Roberto A. , CYR, Kathryn H. , DAY, Michael J. , HAMMERSTAD, Diane R.
IPC: G01N15/10 , G01N1/14 , G01N35/10 , G01N1/2035 , G01N1/40 , G01N15/0266 , G01N15/0656 , G01N2001/2064 , G01N35/1009
Abstract: In one example in accordance with the present disclosure, am ejection system is described. The ejection system includes a fluid feed slot to supply fluid to a number of fluid ejection channels where each fluid ejection channel is a recirculating channel. Each fluid ejection channel includes a sensor to detect, in the fluid, a target particle to be ejected and a fluid ejector to eject the target particle from the fluid ejection channel. The ejection system also includes a controller to selectively activate the fluid ejector when the target particle presence is detected. Non-target particles are returned to the fluid feed slot past the fluid ejector.
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公开(公告)号：WO2021257069A1
公开(公告)日：2021-12-23
申请号：PCT/US2020/038156
申请日：2020-06-17
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： NIELSEN, Jeffrey A. , SHKOLNIKOV, Viktor , MIDTTVEIT, Erica , PUGLIESE, Roberto A. , SMITH, Matthew D. , DAY, Michael J. , HAMMERSTAD, Diane R.
Abstract: A method of detecting passage of a particle into a target location includes receiving a sample on a die including a microfluidic chamber, the microfluidic chamber including a microfluidic path coupling a reservoir to a foyer, and moving the sample from the reservoir to the foyer by firing a nozzle fluidically coupled to the foyer. The method further includes detecting passage of a particle of the sample from the reservoir to the foyer via a first sensor disposed within the microfluidic path, and detecting passage of the particle into the target location via a second sensor disposed between the first sensor and the nozzle. The method includes recording in a dispense map, an indication of whether the target location includes a single particle or multiple particles based on signals measured by the first sensor and the second sensor.
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公开(公告)号：WO2020145995A1
公开(公告)日：2020-07-16
申请号：PCT/US2019/013411
申请日：2019-01-13
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： SHKOLNIKOV, Viktor , HAMMERSTAD, Diane R.
Abstract: A particle classification system may include a volume to contain a fluid having a suspended particle, electrodes proximate the volume to apply an electric field to rotate the suspended particle, a focused light source, a scattered light sensor to sense light from the focused light source that has scattered upon impinging the rotating suspended particle and a controller to classify the particle based at least in part upon signals from the scattered light sensor.
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Patent Agency Ranking
公开(公告)号：WO2019236054A1
公开(公告)日：2019-12-12
申请号：PCT/US2018/035891
申请日：2018-06-04
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Abstract: In one example in accordance with the present disclosure, a fluidic die is described. The fluidic die includes an array of ejection subassemblies. Each ejection subassembly is stationary during fluid deposition and includes 1) an ejection chamber to hold a volume of fluid, 2) an opening, and 3) a fluid actuator to eject the volume of fluid through the opening. In this example, a set of ejection subassemblies that match a pattern to be formed on a stationary substrate are activated.
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公开(公告)号：WO2009136905A1
公开(公告)日：2009-11-12
申请号：PCT/US2008/062662
申请日：2008-05-05
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. , BEERS, Ted , HAMMERSTAD, Diane R. , DEROCHER, Michael D. , BREWSTER, Jon A. , MANDIGO, Lonnie D. , MITCHELL, April S. , O'HARA, Kenton
Inventor： BEERS, Ted , HAMMERSTAD, Diane R. , DEROCHER, Michael D. , BREWSTER, Jon A. , MANDIGO, Lonnie D. , MITCHELL, April S. , O'HARA, Kenton
Abstract: An event management system is configured to provide a communications pathway between persons associated with a scheduled event prior to initiating the scheduled event.
Abstract translation: 事件管理系统被配置为在发起调度的事件之前提供与预定事件相关联的人之间的通信路径。
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公开(公告)号：WO2021015779A1
公开(公告)日：2021-01-28
申请号：PCT/US2019/043393
申请日：2019-07-25
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： GOVYADINOV, Alexander , SHKOLNIKOV, Viktor , HAMMERSTAD, Diane R.
Abstract: In example implementations, an apparatus is provided. The apparatus includes a channel, an energy source, and a transfection chamber. The channel includes an indentation to hold a cell. The energy source is to apply a shockwave to the cell in the channel to porate the cell. The transfection chamber is to store a reagent to be inserted into the cell after the cell is porated.
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公开(公告)号：WO2020032969A1
公开(公告)日：2020-02-13
申请号：PCT/US2018/046201
申请日：2018-08-10
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： GOVYADINOV, Alexander , HAMMERSTAD, Diane R. , SHKOLNIKOV, Viktor
Abstract: In one example in accordance with the present disclosure, a conductivity-based lysis monitor is described. The lysis monitoring device includes a lysing chamber to receive a cell to be lysed and at least one lysing device to rupture a cell membrane. At least one pair of electrodes are disposed in the lysing chamber to detect a level of conductivity in the lysing chamber. A controller of the device determines when the cell membrane has ruptured based on detected levels of conductivity in the lysing chamber.
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公开(公告)号：WO2019059936A1
公开(公告)日：2019-03-28
申请号：PCT/US2017/053121
申请日：2017-09-23
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： SHKOLNIKOV, Viktor , HAMMERSTAD, Diane R. , CUMBIE, Michael W.
Abstract: An electroporation system may include a well plate, a dispenser and a dispenser-well positioning system. The well plate may include wells, each of the wells including an interior, a first electrode adjacent the interior and a second electrode adjacent the interior and spaced from the first electrode. The first electrode and the second electrode are to apply an electrostatic field across the well. The dispenser is to dispense a cell having a diameter into each of the wells. The dispenser-well positioning system is to align each well and the dispenser such that the dispenser dispenses the cell into each well at a location spaced from the first electrode and the second electrode by a distance of at least 5 times the diameter of the cell.
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