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公开(公告)号：JPH1169977A
公开(公告)日：1999-03-16
申请号：JP18370598
申请日：1998-06-30
Applicant: HOECHST AG
Inventor： THEN JOHANN , BARTSCH KLAUS , DEGER HANS-MATTHIAS , GRABLEY SUSANNE , MARQUARDT RUEDIGER
IPC: C12N15/09 , C12N1/20 , C12N1/21 , C12N9/10 , C12N15/00 , C12N15/54 , C12P13/04 , C12P13/06 , C12R1/01 , C12R1/05 , C12R1/185 , C12R1/19 , C12R1/38 , C12R1/425 , C12R1/465
Abstract: PROBLEM TO BE SOLVED: To efficiently produce L-tertiary leucine useful for an asymmetric synthesis or the like of an amino acid derivative in good efficiency, high purity and high yield by carrying out an amino exchange of dimethyloxobutanoic acid (salt) in the presence of an amino acid by using a microorganism. SOLUTION: 3,3-Dimethyl-2-oxobutanoic acid (salt) is subjected to an amino exchange in the presence of an amino acid as an amino group donor by using a microorganism such as Alcaligenes faecalis DSM 4115, for example, at pH 5-9, preferably 7-8.5 to provide the objective L-tertiary leucine in the method for producing the objective L-tertiary leucine. Preferably, the amino group donor and 3,3-dimethyl-2-oxobutanoic acid are used in the ratio of (1/1)-(2/1), and the amino exchange reaction is carried out by using a cell-extract, an isolated total protein or a purified transaminase.
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公开(公告)号：TR9801862T2
公开(公告)日：1998-12-21
申请号：TR9801862
申请日：1997-03-07
Applicant: HOECHST AG
Inventor： BARTLETT ROBERT , THEN JOHANN
IPC: A61K31/167 , A61K31/00 , A61K31/275 , A61K31/42 , A61P11/00 , A61P11/06 , A61P17/00 , A61P17/06 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P37/08 , C07D261/18
CPC classification number: C07D261/18 , A61K31/42 , A61K31/275 , A61K2300/00
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公开(公告)号：TR199801862T2
公开(公告)日：1998-12-21
申请号：TR9801862
申请日：1997-03-07
Applicant: HOECHST AG
Inventor： BARTLETT ROBERT , THEN JOHANN
IPC: A61K31/167 , A61K31/00 , A61K31/275 , A61K31/42 , A61P11/00 , A61P11/06 , A61P17/00 , A61P17/06 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P37/08 , C07D261/18
Abstract: A solid composition comprising 5-methyl-4'-trifluoromethyl-4-isoxazole carboxanilide and N-(4-trifluoromethylphenyl)-2-cyano-3-hydroxycrotonic acid amide, suitable for treatment of immunological and cancerous diseases.
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公开(公告)号：CZ9802985A3
公开(公告)日：1998-12-16
申请号：CZ298598
申请日：1997-03-07
Applicant: HOECHST AG
Inventor： BARTLETT ROBERT , THEN JOHANN
IPC: A61K31/167 , A61K31/00 , A61K31/275 , A61K31/42 , A61P11/00 , A61P11/06 , A61P17/00 , A61P17/06 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P37/08 , C07D261/18
CPC classification number: C07D261/18 , A61K31/42 , A61K31/275 , A61K2300/00
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公开(公告)号：NO984343D0
公开(公告)日：1998-09-18
申请号：NO984343
申请日：1998-09-18
Applicant: HOECHST AG
Inventor： BARTLETT ROBERT , THEN JOHANN
IPC: A61K31/167 , A61K31/00 , A61K31/275 , A61K31/42 , A61P11/00 , A61P11/06 , A61P17/00 , A61P17/06 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P37/08 , C07D261/18
Abstract: A solid composition comprising 5-methyl-4'-trifluoromethyl-4-isoxazole carboxanilide and N-(4-trifluoromethylphenyl)-2-cyano-3-hydroxycrotonic acid amide, suitable for treatment of immunological and cancerous diseases.
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Patent Agency Ranking
公开(公告)号：CA1335658C
公开(公告)日：1995-05-23
申请号：CA538712
申请日：1987-06-03
Applicant: HOECHST AG
Inventor： THEN JOHANN , BARTSCH KLAUS , DEGER HANS-MATTHIAS , GRABLEY SUSANNE , MARQUARDT RUEDIGER
IPC: C12N15/09 , C12N1/20 , C12N1/21 , C12N9/10 , C12N15/00 , C12N15/54 , C12P13/04 , C12P13/06 , C12R1/01 , C12R1/05 , C12R1/185 , C12R1/19 , C12R1/38 , C12R1/425 , C12R1/465 , C07C229/08 , C07F9/30
Abstract: L-tertiary-Leucine and L-phosphinothricine are obtainable by transamination of the corresponding keto acids as a precursor in the presence of amino acids as amino group donors. The reaction is preferably carried out with microorganisms or their transaminases.
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公开(公告)号：AU602148B2
公开(公告)日：1990-10-04
申请号：AU7379487
申请日：1987-06-03
Applicant: HOECHST AG
Inventor： THEN JOHANN , BARTSCH KLAUS , DEGER HANS-MATTHIAS , GRABLEY SUSANNE , MARQUARDT RUDIGER
IPC: C12N15/09 , C12N1/20 , C12N1/21 , C12N9/10 , C12N15/00 , C12N15/54 , C12P13/04 , C12P13/06 , C12R1/01 , C12R1/05 , C12R1/185 , C12R1/19 , C12R1/38 , C12R1/425 , C12R1/465 , C07F9/30
Abstract: Prodn. of L-tert.-leucine (Ia) or L-phosphinothricin (Ib) is effected by tranamination of 3,3-dimethyl-2-oxobutyric acid (IIa) or (3-carboxy-3-oxopropyl)methylphosphinic acid (IIb), or their salts, with an amino acid (III) as amino gp. binder. Pref. the reaction is effected in the presence of a transaminase enzyme at pH 7-8.5 using a (III):(II) ratio of 1-5:1, esp. 1-2:1. The enzyme is used in pure form, in the form of a microorganism, or in the form of a cell extract or protein isolate derived from a microorganism. The microorganism is a Paracoccus, Alcaligenes, Pseudomonas, Serratia, Agrobacterium, Streptomyces or Enterbacterium strain, or a genetically manipulated microorganism, esp. E.coli ATCC 11303 transformed with a plasmid contg. a tyrB or 1lvE gene.
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公开(公告)号：FI883139A
公开(公告)日：1989-01-03
申请号：FI883139
申请日：1988-06-30
Applicant: HOECHST AG
Inventor： THEN JOHANN , HAMMANN PETER , WOEHNER GERHARD , MARQUARDT RUEDIGER , MIXICH JOHANN
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公开(公告)号：NO880278L
公开(公告)日：1988-07-25
申请号：NO880278
申请日：1988-01-22
Applicant: HOECHST AG
Inventor： BRAEU BARBARA , WOEHNER GERHARD , SEIBERT GERHARD , THEN JOHANN
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公开(公告)号：NO872332A
公开(公告)日：1987-12-07
申请号：NO872332
申请日：1987-06-03
Applicant: HOECHST AG
Inventor： THEN JOHANN , BARTSCH KLAUS , DEGER HANS-MATTHIAS , GRABLEY SUSANNE , MARQUARDT RUDIGER
IPC: C12N15/09 , C12N1/20 , C12N1/21 , C12N9/10 , C12N15/00 , C12N15/54 , C12P13/04 , C12P13/06 , C12R1/01 , C12R1/05 , C12R1/185 , C12R1/19 , C12R1/38 , C12R1/425 , C12R1/465 , C12P , C07C101/00 , C07F9/50
CPC classification number: C12P13/06 , C12N9/1096 , C12P13/04
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