公开(公告)号：DK0581250T3

公开(公告)日：1999-09-27

申请号：DK93112006

申请日：1993-07-27

Applicant: HOECHST AG ,  AVENTIS RES & TECH GMBH & CO

Inventor： KRETZSCHMAR GERHARD DR ,  MEIWES JOHANNES DR ,  SCHUDOK MANFRED DR ,  HAMMANN PETER DR ,  LERCH ULRICH DR ,  GRABLEY SUSANNE DR

IPC: C07D233/64 ,  C07D333/24 ,  C07D333/28 ,  C07D333/42 ,  C07D409/06 ,  C07K1/00 ,  C12P13/04 ,  C12P13/06 ,  C12P17/00 ,  C12R1/01 ,  C12R1/19

Abstract: The preparation of L-thienylalanine takes place by the hydantoin or azlactone route. 2-Hydroxy-3-thienylacrylic acids are used as starting material for the biotransformation. The innovative step comprises the transamination of the enol form of 2-hydroxy-3-thienylacrylic acids to give L-thienylalanines by means of the biotransformation. The transamination takes place in the presence of L-aspartic or L-glutamic acid as amino donor.

公开(公告)号：CS276179B6

公开(公告)日：1992-04-15

申请号：CS212687

申请日：1987-03-27

Applicant: HOECHST AG

Inventor： HOCK FRANZ DR ,  SCHOLTHOLT JOSEF PROF DR ,  URBACH HANSJORG DR ,  HENNING RAINER DR ,  LERCH ULRICH DR ,  NICKEL WOLF-ULRICH DR ,  RUGER WOLFGANG DR

IPC: C07K14/81 ,  A61K38/00 ,  A61P9/12 ,  A61P25/28 ,  C07C235/02 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07C237/00

Abstract: The invention relates to novel compounds having a nootropic activity, the use of ACE inhibitors as medicaments having nootropic activity, agents containing them, and their use in the treatment and prophylaxis of cognitive malfunctions.

公开(公告)号：CS212687A3

公开(公告)日：1992-04-15

申请号：CS212687

申请日：1987-03-27

Applicant: HOECHST AG

Inventor： HOCK FRANZ DR ,  SCHOLTHOLT JOSEF PROF DR ,  URBACH HANSJORG DR ,  HENNING RAINER DR ,  LERCH ULRICH DR ,  NICKEL WOLF-ULRICH DR ,  RUGER WOLFGANG DR

IPC: C07K14/81 ,  A61K38/00 ,  A61P9/12 ,  A61P25/28 ,  C07C235/02 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07C233/50 ,  C07C233/68

Abstract: The invention relates to novel compounds having a nootropic activity, the use of ACE inhibitors as medicaments having nootropic activity, agents containing them, and their use in the treatment and prophylaxis of cognitive malfunctions.

公开(公告)号：DE3347173A1

公开(公告)日：1985-07-04

申请号：DE3347173

申请日：1983-12-27

Applicant: HOECHST AG

Inventor： HENNING RAINER DR ,  LERCH ULRICH DR ,  KAISER JOACHIM DR

IPC: A61K31/54 ,  A61K31/5415 ,  A61P3/00 ,  A61P9/00 ,  C07D279/16 ,  C07D317/00 ,  C07D417/04 ,  C07D417/12 ,  C07D417/10

Abstract: Benzothiazine derivatives of the formula I (I) with (R(1), R(1)', R(1)'', R(4) and R(4)' equal to hydrogen, alkyl, alkoxy, halogen, nitro, hydroxyl, acetamido or amino; R(2) equal to hydrogen, alkyl, alkenyl, phenyl; R(3) equal to hydrogen, alkyl, alkenyl, phenyl; R(5) equal to hydrogen or (C1-C3)-alkyl; R(6) equal to one of the following groups, with R(7) and R(8) equal to hydrogen, alkyl, cycloalkyl, phenyl; R(9) equal to hydrogen, alkyl, phenyl, pyridyl, pyrimidinyl or benzoyl; R(10) equal to hydrogen, alkyl, phenyl; R(11) equal to hydrogen, hydroxyl, alkoxy or, together with R(12), a bond; and R(12) equal to hydrogen or, together with R(11), a bond; m equal to 1, 2, 3 or 4; n equal to 0 or 1; p equal to 0, 1, 2, 3 or 4, and X equal to oxygen or two hydrogen atoms, and salts of the compounds of the formula I with physiologically tolerated acids and a process for the preparation of compounds I, likewise a method of treatment of disturbances of the calcium balance of a human body are described.

公开(公告)号：DE3340773A1

公开(公告)日：1985-05-30

申请号：DE3340773

申请日：1983-11-11

Applicant: HOECHST AG

Inventor： LERCH ULRICH DR ,  RENGER BERND DR

IPC: C07C273/18 ,  C07D239/60 ,  C07D471/04 ,  A61K31/505

Abstract: The present invention relates to a novel process for the preparation of substituted 2-imino-3,4,6,7-tetrahydro-4H-pyrimido[6,1-a]isoquinolin-4-ones of the formula I Compared with the known preparation process, the process according to the invention is shorter and gives a higher total yield.

公开(公告)号：DE3301198A1

公开(公告)日：1984-07-19

申请号：DE3301198

申请日：1983-01-15

Applicant: HOECHST AG

Inventor： KNOLLE JOCHEN DR ,  LERCH ULRICH DR ,  RENGER BERND DR ,  SCHOELKENS BERNWARD DR

IPC: C07D213/64 ,  C07D213/85 ,  C07D263/06 ,  A61K31/44 ,  C07D213/61 ,  C07D213/69 ,  C07D213/84

Abstract: Racemic and optically active N-arylalkylamine-3-propoxypyridine derivatives of the formula I in which R to R have the meanings given, and their physiologically tolerable salts, process for the preparation of these compounds, their use in the treatment of cardiovascular diseases and pharmaceutical preparations based on these compounds.

公开(公告)号：CH637115A5

公开(公告)日：1983-07-15

申请号：CH1052078

申请日：1978-10-10

Applicant: HOECHST AG

Inventor： BARTMANN WILHELM DR ,  LERCH ULRICH DR ,  TEUFEL HERMANN DR ,  SCHOELKENS BERNWARD DR ,  BECK GERHARD DR

IPC: C07C405/00 ,  C07D317/72 ,  C07D339/06 ,  C07C177/00 ,  A61K31/557

公开(公告)号：DE3063556D1

公开(公告)日：1983-07-07

申请号：DE3063556

申请日：1980-01-21

Applicant: HOECHST AG

Inventor： BARTMANN WILHELM DR ,  KONZ ELMAR DR ,  LERCH ULRICH DR ,  SCHOLKENS BERNWARD DR

IPC: C07D307/935 ,  A61K31/34 ,  A61K31/343 ,  A61K31/557 ,  A61P7/02 ,  C07D307/937

Abstract: What is disclosed are prostacyclin analogs of the general formula I I which have a more specific action and/or a longer action than the naturally occurring prostacyclin PGI2, as well as intermediate products for their preparation and a process for their preparation. The compounds of formula I are distinguished by inhibitory action on thrombocyte aggregation and by relaxation of the vascular walls, in particular of the coronary arteries. They can thus be used as medicaments.

公开(公告)号：DE2962192D1

公开(公告)日：1982-03-25

申请号：DE2962192

申请日：1979-07-05

Applicant: HOECHST AG

Inventor： BARTMANN WILHELM DR ,  BECK GERHARD DR ,  LERCH ULRICH DR ,  BICKEL MARTIN DR

IPC: C07D317/72 ,  A61K31/557 ,  A61K31/5575 ,  A61P43/00 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D319/14 ,  C07D407/12 ,  C07F9/535 ,  C07F9/54 ,  C07C177/00

公开(公告)号：CH612936A5

公开(公告)日：1979-08-31

申请号：CH950975

申请日：1975-07-21

Applicant: HOECHST AG

Inventor： BECK GERHARD DR ,  BARTMANN WILHELM DR ,  LERCH ULRICH DR ,  SCHOELKENS BERNWARD DR

IPC: A61K31/21 ,  A61K31/557 ,  A61K31/5575 ,  A61P43/00 ,  C07C67/00 ,  C07C271/28 ,  C07C401/00 ,  C07C405/00 ,  C07D307/935 ,  C07C177/00

Abstract: The present invention relates to new analogues which do not occur naturally of prostanoic acids of the formula I I The compounds of the invention have spasmogenic, bronchodilatant and hypotensive properties. Therefore, they can be used as medicaments. This invention also relates to a process for preparing the compounds of the invention.