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公开(公告)号：DE59004397D1
公开(公告)日：1994-03-10
申请号：DE59004397
申请日：1990-09-18
Applicant: HOECHST AG
Inventor： BUCHHOLZ RAINER DR , GIANI CARLO DR , FRICKE ULRICH , RUEPPEL DIETER DR , WALCH AXEL DR , BAYER THOMAS DR , KURRLE ROLAND DR , KRAUSE DIETER , LANG WIEGAND , REICHE ASMUS DR
Abstract: The invention relates to a process for the culture of cells which are entrapped in hollow microbeads and are densely packed in a fixed bed and are supplied with nutrients discontinuously or continuously in a vessel by the medium flow. The suitable hollow microbeads have a membrane composed of a polysaccharide gel or of a polyelectrolyte.
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公开(公告)号：DK0418796T3
公开(公告)日：1994-04-11
申请号：DK90117893
申请日：1990-09-18
Applicant: HOECHST AG
Inventor： KURRLE ROLAND DR , BUCHHOLZ RAINER DR , GIANI CARLO DR , FRICKE ULRICH , WALCH AXEL DR , BAYER THOMAS DR , KRAUSE DIETER , LANG WIEGAND , REICHE ASMUS DR
Abstract: The invention relates to a process for the culture of cells which are entrapped in hollow microbeads and are densely packed in a fixed bed and are supplied with nutrients discontinuously or continuously in a vessel by the medium flow. The suitable hollow microbeads have a membrane composed of a polysaccharide gel or of a polyelectrolyte.
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公开(公告)号：AT91506T
公开(公告)日：1993-07-15
申请号：AT89100294
申请日：1989-01-10
Applicant: HOECHST AG
Inventor： BAYER THOMAS DR , BUCHHOLZ RAINER DR , DEGER HANS-MATTHIAS DR , WINK JOACHIM DR
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公开(公告)号：DE59107275D1
公开(公告)日：1996-02-29
申请号：DE59107275
申请日：1991-09-04
Applicant: HOECHST AG
Inventor： BAYER THOMAS DR , SAUBER KLAUS DR
Abstract: A process for the continuous conversion of cephalosporin derivatives into glutaryl-7-aminocephalosporanic acid derivatives A process for the continuous conversion of cephalosporin derivatives into the corresponding glutaryl-7-aminocephalosporanic acid derivatives in the presence of a catalyst containing D-amino-acid oxidase is described. The product yield can be increased, where appropriate, by addition of hydrogen peroxide.
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公开(公告)号：DE3931433A1
公开(公告)日：1991-04-04
申请号：DE3931433
申请日：1989-09-21
Applicant: HOECHST AG
Inventor： BUCHHOLZ RAINER DR , GIANI CARLO DR , FRICKE ULRICH DIPL ING , RUEPPEL DIETHER DR , WALCH AXEL DR , BAYER THOMAS DR
Abstract: The invention relates to a process for the culture of cells which are entrapped in hollow microbeads and are densely packed in a fixed bed and are supplied with nutrients discontinuously or continuously in a vessel by the medium flow. The suitable hollow microbeads have a membrane composed of a polysaccharide gel or of a polyelectrolyte.
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Patent Agency Ranking
公开(公告)号：DK0474211T3
公开(公告)日：1996-05-20
申请号：DK91114933
申请日：1991-09-04
Applicant: HOECHST AG
Inventor： BAYER THOMAS DR , SAUBER KLAUS DR
Abstract: A process for the continuous conversion of cephalosporin derivatives into glutaryl-7-aminocephalosporanic acid derivatives A process for the continuous conversion of cephalosporin derivatives into the corresponding glutaryl-7-aminocephalosporanic acid derivatives in the presence of a catalyst containing D-amino-acid oxidase is described. The product yield can be increased, where appropriate, by addition of hydrogen peroxide.
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公开(公告)号：GR3018713T3
公开(公告)日：1996-04-30
申请号：GR950403689
申请日：1996-01-18
Applicant: HOECHST AG
Inventor： BAYER THOMAS DR , SAUBER KLAUS DR
Abstract: A process for the continuous conversion of cephalosporin derivatives into glutaryl-7-aminocephalosporanic acid derivatives A process for the continuous conversion of cephalosporin derivatives into the corresponding glutaryl-7-aminocephalosporanic acid derivatives in the presence of a catalyst containing D-amino-acid oxidase is described. The product yield can be increased, where appropriate, by addition of hydrogen peroxide.
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公开(公告)号：DE3801588A1
公开(公告)日：1989-08-10
申请号：DE3801588
申请日：1988-01-21
Applicant: HOECHST AG
Inventor： BAYER THOMAS DR , BUCHHOLZ RAINER DR , DEGER HANS-MATTHIAS DR , WINK JOACHIM DR
IPC: A23L5/41 , A61K31/365 , A61K36/06 , C09B61/00 , C12N1/14 , C12P1/02 , C12P17/02 , C12P17/18 , C12R1/645
Abstract: The process entails cultivation of a microorganism of the genus Monascus in a water-depleted, sterilisable fluidised bed fermenter as has been proposed in German Patent Application P 36 25 698.6. The microorganism itself - in pellet form or grown on carriers - is used as fluidisable particle and can be supplied with nutrients by spraying substrate solutions in. The dyes and/or active substances are isolated by extraction with organic solvents.
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公开(公告)号：ES2083495T3
公开(公告)日：1996-04-16
申请号：ES91114933
申请日：1991-09-04
Applicant: HOECHST AG
Inventor： BAYER THOMAS DR , SAUBER KLAUS DR
Abstract: A process for the continuous conversion of cephalosporin derivatives into glutaryl-7-aminocephalosporanic acid derivatives A process for the continuous conversion of cephalosporin derivatives into the corresponding glutaryl-7-aminocephalosporanic acid derivatives in the presence of a catalyst containing D-amino-acid oxidase is described. The product yield can be increased, where appropriate, by addition of hydrogen peroxide.
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公开(公告)号：AT133204T
公开(公告)日：1996-02-15
申请号：AT91114933
申请日：1991-09-04
Applicant: HOECHST AG
Inventor： BAYER THOMAS DR , SAUBER KLAUS DR
Abstract: A process for the continuous conversion of cephalosporin derivatives into glutaryl-7-aminocephalosporanic acid derivatives A process for the continuous conversion of cephalosporin derivatives into the corresponding glutaryl-7-aminocephalosporanic acid derivatives in the presence of a catalyst containing D-amino-acid oxidase is described. The product yield can be increased, where appropriate, by addition of hydrogen peroxide.
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