公开(公告)号：JPH1171323A

公开(公告)日：1999-03-16

申请号：JP13548798

申请日：1998-05-18

Applicant: HOECHST AG

Inventor： ARETZ WERNER ,  BOETTGER DIRK ,  SEIBERT GERHARD ,  TUMULKA ALOIS ,  WELZEL PETER ,  HOBERT KURT

IPC: A61K31/19 ,  A61P31/04 ,  C07C59/125 ,  C07C59/60 ,  C07F9/09 ,  C07F9/655 ,  C07H13/12 ,  C07H15/203 ,  C12N1/20 ,  C12N9/16 ,  C12N9/99 ,  C12P7/42 ,  C12P9/00 ,  C12P19/26 ,  C12P19/44 ,  C12R1/07

Abstract: PROBLEM TO BE SOLVED: To obtain a new compound useful as an antibacterial agent or its intermediate. SOLUTION: The objective compound is a cleavage product of a phosphoglycolipid antibiotic substance of the formula I (R is H; R is a 5-55C alkyl). A cultured product of Bacillus DSM 4675 or its processed product, especially a separated enzyme is usable for the decomposition of a phosphoglycolipid antibiotic substance, especially antibiotic substances of moenomycin group. Moenomycin A is incubated with moenomycinase preferably at pH 8.2-8.3 and 49-51 deg.C to obtain the compounds of the formula II and III and the compound of the formula III is incubated with an MBase preferably at pH 6-8 and 35-37 deg.C for 24 hr to obtain the compound of the formula IV. The reaction product can be used as an antibiotic substance (e.g. the compound of the formula III) or a basic unit (e.g. the compound of the formula II and IV) in the synthesis of a transglycosylase inhibitor.

公开(公告)号：FI81608C

公开(公告)日：1990-11-12

申请号：FI852696

申请日：1985-07-08

Applicant: HOECHST AG

Inventor： ARETZ WERNER ,  BERSCHEID HANS GERD ,  FEHLHABER HANS-WOLFRAM ,  BOETTGER DIRK ,  KRAEMER HANS PETER

IPC: C07C50/36 ,  A61K31/12 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P35/00 ,  C07C45/00 ,  C07C67/00 ,  C07H15/252 ,  C12P7/26 ,  C12P19/56 ,  C12R1/465 ,  C12P15/00 ,  C07H15/24

公开(公告)号：NO893327A

公开(公告)日：1990-02-21

申请号：NO893327

申请日：1989-08-18

Applicant: HOECHST AG

Inventor： ARETZ WERNER ,  BOETTGER DIRK ,  SEIBERT GERHARD ,  TUMULKA ALOIS ,  WELZEL PETER ,  HOBERT KURT

IPC: A61K31/19 ,  A61P31/04 ,  C07C59/125 ,  C07C59/60 ,  C07F9/09 ,  C07F9/655 ,  C07H13/12 ,  C07H15/203 ,  C12N1/20 ,  C12N9/16 ,  C12N9/99 ,  C12P7/42 ,  C12P9/00 ,  C12P19/26 ,  C12P19/44 ,  C12R1/07 ,  C12N9/14

CPC classification number: C07H13/12 ,  C07C59/125 ,  C07C59/60 ,  C07F9/091 ,  C07F9/6552 ,  C12N9/16 ,  C12P7/42 ,  C12P19/26 ,  C12P19/44 ,  C12R1/07

公开(公告)号：ZA865690B

公开(公告)日：1987-03-25

申请号：ZA865690

申请日：1986-07-30

Applicant: HOECHST AG

Inventor： ARETZ WERNER ,  BOETTGER DIRK ,  SAUBER KLAUS

IPC: C07D311/92 ,  C12P17/06 ,  C12R1/645 ,  C07D ,  A61K ,  C12P

Abstract: Forskolin analogues and derivatives are prepared by means of microbial transformations by microorganisms of the strain Neurospora crassa. The compounds prepared according to the invention have varied pharmacological effects and can therefore be used as medicaments.

公开(公告)号：ZA855154B

公开(公告)日：1986-02-26

申请号：ZA855154

申请日：1985-07-09

Applicant: HOECHST AG

Inventor： ARETZ WERNER ,  BERSCHEID HANS GERD ,  FEHLHABER HANS-WOLFRAM ,  BOETTGER DIRK ,  KRAEMER HANS PETER

IPC: C07C50/36 ,  A61K31/12 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P35/00 ,  C07C45/00 ,  C07C67/00 ,  C07H15/252 ,  C12P7/26 ,  C12P19/56 ,  C12R1/465 ,  A61K ,  C12R ,  C12P ,  C07H

Abstract: 1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Compounds of the formula I see diagramm : EP0167954,P12,F1 wherein a) R1 and R2 are identical and each represent the sugar combination Roa-Rod-Rod or Roa-dF=CinB, or b) R1 and R2 are different and each represent the sugar combination Roa-Rod-Rod and Roa-dF-Rod, or c) R1 and R2 are different, R1 representing the sugar combination Roa-dF-CinA and R2 representing the sugar combination Roa-Rod-Rod or Roa-Rod-Acu, or R1 representing the sugar combination Roa-Rod-Acu and R2 representing the sugar combination Roa-Rod-Rod and their physiologically acceptable acid addition salts. 1. Claims for the Contracting State : AT A process for the preparation of a compound of the formula I see diagramm : EP0167954,P12,F2 wherein a) R1 and R2 are identical and each represent the sugar combination Roa-Rod-Rod or Roa-dF=CinB, or b) R1 and R2 are different and each represent the sugar combination Roa-Rod-Rod and Roa-dF-Rod, or c) R1 and R2 are different, R1 representing the sugar combination Roa-dF-CinA and R2 representing the sugar combination Roa-Rod-Rod or Roa-Rod-Acu, or R1 representing the sugar combination Roa-Rod-Acu and R2 representing the sugar combination Roa-Rod-Rod, and their physiologically acceptable acid addition salts, which comprises fermenting the microorganism Streptomyces purpurascens (DSM 2658) in the presence of a nutrient medium with an elevated oxygen supply, otherwise in a customary manner under aerobic conditions, and isolating the compounds formed from the culture liquid and the mycelium by extraction with organic solvents followed by chromatography or partition in a customary manner.

公开(公告)号：NO852758L

公开(公告)日：1986-01-13

申请号：NO852758

申请日：1985-07-09

Applicant: HOECHST AG

Inventor： ARETZ WERNER ,  BERSCHEID HANS GERD ,  FEHLHABER HANS-WOLFRAM ,  BOETTGER DIRK ,  KRAEMER HANS PETER

IPC: C07C50/36 ,  A61K31/12 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P35/00 ,  C07C45/00 ,  C07C67/00 ,  C07H15/252 ,  C12P7/26 ,  C12P19/56 ,  C12R1/465 ,  C12P

Abstract: 1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Compounds of the formula I see diagramm : EP0167954,P12,F1 wherein a) R1 and R2 are identical and each represent the sugar combination Roa-Rod-Rod or Roa-dF=CinB, or b) R1 and R2 are different and each represent the sugar combination Roa-Rod-Rod and Roa-dF-Rod, or c) R1 and R2 are different, R1 representing the sugar combination Roa-dF-CinA and R2 representing the sugar combination Roa-Rod-Rod or Roa-Rod-Acu, or R1 representing the sugar combination Roa-Rod-Acu and R2 representing the sugar combination Roa-Rod-Rod and their physiologically acceptable acid addition salts. 1. Claims for the Contracting State : AT A process for the preparation of a compound of the formula I see diagramm : EP0167954,P12,F2 wherein a) R1 and R2 are identical and each represent the sugar combination Roa-Rod-Rod or Roa-dF=CinB, or b) R1 and R2 are different and each represent the sugar combination Roa-Rod-Rod and Roa-dF-Rod, or c) R1 and R2 are different, R1 representing the sugar combination Roa-dF-CinA and R2 representing the sugar combination Roa-Rod-Rod or Roa-Rod-Acu, or R1 representing the sugar combination Roa-Rod-Acu and R2 representing the sugar combination Roa-Rod-Rod, and their physiologically acceptable acid addition salts, which comprises fermenting the microorganism Streptomyces purpurascens (DSM 2658) in the presence of a nutrient medium with an elevated oxygen supply, otherwise in a customary manner under aerobic conditions, and isolating the compounds formed from the culture liquid and the mycelium by extraction with organic solvents followed by chromatography or partition in a customary manner.

公开(公告)号：CA2075558A1

公开(公告)日：1993-02-09

申请号：CA2075558

申请日：1992-08-07

Applicant: HOECHST AG

Inventor： ROSCHER GUENTER ,  KLEINER HANS-JERG ,  BERGER HARALD ,  SCHMIDT MANFRED ,  UHMANN RAINER ,  BOETTGER DIRK

IPC: C07F9/48 ,  C07F9/38 ,  C08G79/02 ,  C08G79/04

Abstract: Process for the preparation of pure propanephosphonic anhydride, which comprises distilling crude, impure propanephosphonic anhydride having an average degree of polymerization of 20 to 200 and containing less than 0.5% by weight of water by heating to 230 to 300.degree.C under a pressure of 0.1 to 100 mbar, pure propanephosphonic anhydride having an average decree of polymerization of 20 to 60 being obtained.

公开(公告)号：FI893878A

公开(公告)日：1990-02-21

申请号：FI893878

申请日：1989-08-17

Applicant: HOECHST AG

Inventor： ARETZ WERNER ,  BOETTGER DIRK ,  SEIBERT GERHARD ,  TUMULKA ALOIS ,  WELZEL PETER ,  HOBERT KURT

IPC: A61K31/19 ,  A61P31/04 ,  C07C59/125 ,  C07C59/60 ,  C07F9/09 ,  C07F9/655 ,  C07H13/12 ,  C07H15/203 ,  C12N1/20 ,  C12N9/16 ,  C12N9/99 ,  C12P7/42 ,  C12P9/00 ,  C12P19/26 ,  C12P19/44 ,  C12R1/07 ,  C12N

Abstract: It is possible with the aid of a Bacillus species or the appropriate enzymes obtained therefrom to degrade phosphoglycolipid antibiotics. The degradation products of the moenomycins have antibiotic activity or can be used as building block in the synthetic preparation of transglycosylase inhibitors.

公开(公告)号：DK407789A

公开(公告)日：1990-02-21

申请号：DK407789

申请日：1989-08-18

Applicant: HOECHST AG

Inventor： ARETZ WERNER ,  BOETTGER DIRK ,  SEIBERT GERHARD ,  TUMULKA ALOIS ,  WELZEL PETER ,  HOBERT KURT

IPC: A61K31/19 ,  A61P31/04 ,  C07C59/125 ,  C07C59/60 ,  C07F9/09 ,  C07F9/655 ,  C07H13/12 ,  C07H15/203 ,  C12N1/20 ,  C12N9/16 ,  C12N9/99 ,  C12P7/42 ,  C12P9/00 ,  C12P19/26 ,  C12P19/44 ,  C12R1/07 ,  C07C59/42 ,  C12N9/14

Abstract: It is possible with the aid of a Bacillus species or the appropriate enzymes obtained therefrom to degrade phosphoglycolipid antibiotics. The degradation products of the moenomycins have antibiotic activity or can be used as building block in the synthetic preparation of transglycosylase inhibitors.

公开(公告)号：HUT42134A

公开(公告)日：1987-06-29

申请号：HU260585

申请日：1985-07-04

Applicant: HOECHST AG

Inventor： ARETZ WERNER ,  BERSCHEID HANS G ,  BOETTGER DIRK ,  FEHLHABER HANS-WOLFRAM ,  KRAEMER HANS P

IPC: C07C50/36 ,  A61K31/12 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P35/00 ,  C07C45/00 ,  C07C67/00 ,  C07H15/252 ,  C12P7/26 ,  C12P19/56 ,  C12R1/465 ,  C12P19/60 ,  C12P29/00

Abstract: 1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Compounds of the formula I see diagramm : EP0167954,P12,F1 wherein a) R1 and R2 are identical and each represent the sugar combination Roa-Rod-Rod or Roa-dF=CinB, or b) R1 and R2 are different and each represent the sugar combination Roa-Rod-Rod and Roa-dF-Rod, or c) R1 and R2 are different, R1 representing the sugar combination Roa-dF-CinA and R2 representing the sugar combination Roa-Rod-Rod or Roa-Rod-Acu, or R1 representing the sugar combination Roa-Rod-Acu and R2 representing the sugar combination Roa-Rod-Rod and their physiologically acceptable acid addition salts. 1. Claims for the Contracting State : AT A process for the preparation of a compound of the formula I see diagramm : EP0167954,P12,F2 wherein a) R1 and R2 are identical and each represent the sugar combination Roa-Rod-Rod or Roa-dF=CinB, or b) R1 and R2 are different and each represent the sugar combination Roa-Rod-Rod and Roa-dF-Rod, or c) R1 and R2 are different, R1 representing the sugar combination Roa-dF-CinA and R2 representing the sugar combination Roa-Rod-Rod or Roa-Rod-Acu, or R1 representing the sugar combination Roa-Rod-Acu and R2 representing the sugar combination Roa-Rod-Rod, and their physiologically acceptable acid addition salts, which comprises fermenting the microorganism Streptomyces purpurascens (DSM 2658) in the presence of a nutrient medium with an elevated oxygen supply, otherwise in a customary manner under aerobic conditions, and isolating the compounds formed from the culture liquid and the mycelium by extraction with organic solvents followed by chromatography or partition in a customary manner.