公开(公告)号：JPH1169977A

公开(公告)日：1999-03-16

申请号：JP18370598

申请日：1998-06-30

Applicant: HOECHST AG

Inventor： THEN JOHANN ,  BARTSCH KLAUS ,  DEGER HANS-MATTHIAS ,  GRABLEY SUSANNE ,  MARQUARDT RUEDIGER

IPC: C12N15/09 ,  C12N1/20 ,  C12N1/21 ,  C12N9/10 ,  C12N15/00 ,  C12N15/54 ,  C12P13/04 ,  C12P13/06 ,  C12R1/01 ,  C12R1/05 ,  C12R1/185 ,  C12R1/19 ,  C12R1/38 ,  C12R1/425 ,  C12R1/465

Abstract: PROBLEM TO BE SOLVED: To efficiently produce L-tertiary leucine useful for an asymmetric synthesis or the like of an amino acid derivative in good efficiency, high purity and high yield by carrying out an amino exchange of dimethyloxobutanoic acid (salt) in the presence of an amino acid by using a microorganism. SOLUTION: 3,3-Dimethyl-2-oxobutanoic acid (salt) is subjected to an amino exchange in the presence of an amino acid as an amino group donor by using a microorganism such as Alcaligenes faecalis DSM 4115, for example, at pH 5-9, preferably 7-8.5 to provide the objective L-tertiary leucine in the method for producing the objective L-tertiary leucine. Preferably, the amino group donor and 3,3-dimethyl-2-oxobutanoic acid are used in the ratio of (1/1)-(2/1), and the amino exchange reaction is carried out by using a cell-extract, an isolated total protein or a purified transaminase.

公开(公告)号：CA1335658C

公开(公告)日：1995-05-23

申请号：CA538712

申请日：1987-06-03

Applicant: HOECHST AG

Inventor： THEN JOHANN ,  BARTSCH KLAUS ,  DEGER HANS-MATTHIAS ,  GRABLEY SUSANNE ,  MARQUARDT RUEDIGER

IPC: C12N15/09 ,  C12N1/20 ,  C12N1/21 ,  C12N9/10 ,  C12N15/00 ,  C12N15/54 ,  C12P13/04 ,  C12P13/06 ,  C12R1/01 ,  C12R1/05 ,  C12R1/185 ,  C12R1/19 ,  C12R1/38 ,  C12R1/425 ,  C12R1/465 ,  C07C229/08 ,  C07F9/30

Abstract: L-tertiary-Leucine and L-phosphinothricine are obtainable by transamination of the corresponding keto acids as a precursor in the presence of amino acids as amino group donors. The reaction is preferably carried out with microorganisms or their transaminases.

公开(公告)号：DK80292D0

公开(公告)日：1992-06-17

申请号：DK80292

申请日：1992-06-17

Applicant: HOECHST AG

Inventor： THIEM JOACHIM ,  DEGER HANS-MATTHIAS ,  FRITSCHE-LANG WOLFRAM ,  KREUZER MATTHIAS

IPC: B01J23/00 ,  B01J31/00 ,  C07B61/00 ,  C07H1/00 ,  C07H5/02 ,  C07H15/04 ,  C07H15/18

公开(公告)号：PT96148A

公开(公告)日：1991-10-15

申请号：PT9614890

申请日：1990-12-10

Applicant: HOECHST AG

Inventor： BEHME KLAUS-JURGEN ,  DEGER HANS-MATTHIAS

IPC: C08G18/00 ,  C08J9/08 ,  C08J9/14 ,  C08J9/00

公开(公告)号：NO910867L

公开(公告)日：1991-09-09

申请号：NO910867

申请日：1991-03-05

Applicant: HOECHST AG

Inventor： BEHME KLAUS-JUERGEN ,  DEGER HANS-MATTHIAS ,  SCHUETZ CLAUDIA

IPC: C08G18/08 ,  C08G18/00 ,  C08G101/00 ,  C08J9/02 ,  C08J9/14 ,  C08J9/08 ,  C08L75/00

Abstract: A process for the production of foams with the aid of blowing agents containing fluoroalkanes and fluorinated ethers, and the foams obtainable by this process. … The invention relates to a process for the production of foams based on polyisocyanates by reaction of polyisocyanates, compounds containing at least two hydrogen atoms which are reactive towards isocyanate groups, blowing agents and optionally further additives. The blowing agents used here comprise at least 10 mol% of at least one fluoroalkane of the formula (I) CaHbFc, where a = 2-6, b = 1-12 and c = 2-13, and at least one fluorinated ether of the formula (II) CaHbFc-O-CdHeFf, where a = 1-6, b = 1-12, c = 1-12, d = 1-2, e = 0-5 and f = 0-5. … The invention furthermore relates to the foams obtainable by this process.

公开(公告)号：HU908136D0

公开(公告)日：1991-06-28

申请号：HU813690

申请日：1990-12-10

Applicant: HOECHST AG

Inventor： BEHME KLAUS-JUERGEN ,  DEGER HANS-MATTHIAS

IPC: C08G18/00 ,  C08J9/08 ,  C08J9/14

公开(公告)号：HU908073D0

公开(公告)日：1991-06-28

申请号：HU807390

申请日：1990-12-05

Applicant: HOECHST AG

Inventor： BEHME KLAUS-JUERGEN ,  DEGER HANS-MATTHIAS

IPC: C08G18/00 ,  C08J9/14 ,  C08K5/06 ,  C08L75/04

Abstract: A process for the production of foams based on polyisocyanates by reacting polyisocyanates, compounds containing at least two hydrogen atoms which are reactive with isocyanate groups, blowing agents and optionally further additives, where a blowing agent is used which comprises at least 10 mol-% of one or more fluorinated ethers of the formula I… CaHbFc - O - CdHeFf where …… a = 1-6, … b = 1-12, … c = 1-12, … d = 1-2, … e = 0-5 and … f = 0-5. …

公开(公告)号：CA2031970A1

公开(公告)日：1991-06-13

申请号：CA2031970

申请日：1990-12-11

Applicant: HOECHST AG ,  SOLVAY

Inventor： BEHME KLAUS-JUERGEN ,  DEGER HANS-MATTHIAS

IPC: C08G18/00 ,  C08J9/08 ,  C08J9/14 ,  C08G18/08

Abstract: HOE 89/F 392K of the disclosure Process for producing foams with the aid of fluoroalkanes The invention relates to a process for producing foams based on polyisocyanates by reacting polyisocyanates, compounds having at least two hydrogen atoms reactive towards isocyanate groups, blowing agents and, if appropriate, further additives. In this process, a blowing agent is used which is composed to the extent of at least 10 mol % of one or more fluoroalkanes of the formula I CaHbFc where a = 4-6, b = 1-12 and c = 2-13.

公开(公告)号：FI906006A0

公开(公告)日：1990-12-05

申请号：FI906006

申请日：1990-12-05

Applicant: HOECHST AG

Inventor： BEHME KLAUS-JUERGEN ,  DEGER HANS-MATTHIAS

IPC: C08G18/00 ,  C08J9/14 ,  C08K5/06 ,  C08L75/04 ,  C08G

Abstract: A process for the production of foams based on polyisocyanates by reacting polyisocyanates, compounds containing at least two hydrogen atoms which are reactive with isocyanate groups, blowing agents and optionally further additives, where a blowing agent is used which comprises at least 10 mol-% of one or more fluorinated ethers of the formula I… CaHbFc - O - CdHeFf where …… a = 1-6, … b = 1-12, … c = 1-12, … d = 1-2, … e = 0-5 and … f = 0-5. …

公开(公告)号：AU602148B2

公开(公告)日：1990-10-04

申请号：AU7379487

申请日：1987-06-03

Applicant: HOECHST AG

Inventor： THEN JOHANN ,  BARTSCH KLAUS ,  DEGER HANS-MATTHIAS ,  GRABLEY SUSANNE ,  MARQUARDT RUDIGER

IPC: C12N15/09 ,  C12N1/20 ,  C12N1/21 ,  C12N9/10 ,  C12N15/00 ,  C12N15/54 ,  C12P13/04 ,  C12P13/06 ,  C12R1/01 ,  C12R1/05 ,  C12R1/185 ,  C12R1/19 ,  C12R1/38 ,  C12R1/425 ,  C12R1/465 ,  C07F9/30

Abstract: Prodn. of L-tert.-leucine (Ia) or L-phosphinothricin (Ib) is effected by tranamination of 3,3-dimethyl-2-oxobutyric acid (IIa) or (3-carboxy-3-oxopropyl)methylphosphinic acid (IIb), or their salts, with an amino acid (III) as amino gp. binder. Pref. the reaction is effected in the presence of a transaminase enzyme at pH 7-8.5 using a (III):(II) ratio of 1-5:1, esp. 1-2:1. The enzyme is used in pure form, in the form of a microorganism, or in the form of a cell extract or protein isolate derived from a microorganism. The microorganism is a Paracoccus, Alcaligenes, Pseudomonas, Serratia, Agrobacterium, Streptomyces or Enterbacterium strain, or a genetically manipulated microorganism, esp. E.coli ATCC 11303 transformed with a plasmid contg. a tyrB or 1lvE gene.