公开(公告)号：CA2086972A1

公开(公告)日：1993-07-10

申请号：CA2086972

申请日：1993-01-08

Applicant: HOECHST AG

Inventor： HOLLA WOLFGANG ,  BECKER GUENTHER ,  STAHL WILHELM ,  SCHUDOK MANFRED ,  THIEM JOACHIM ,  SAUERBREI BERND

IPC: C07H15/04 ,  C07K9/00 ,  C12N9/38 ,  C12P19/14 ,  C12P19/26 ,  C12P19/44 ,  C12P21/02 ,  C12P21/00

Abstract: HOE 92/F 001 of the disclosure The invention relates to a process for .beta.-galactosidase-catalyzed transglycosidation, wherein unphysiological or unnatural glycosides are employed as glycosyl donors for .beta.-galactosidase.

公开(公告)号：FI84483C

公开(公告)日：1991-12-10

申请号：FI872094

申请日：1987-05-12

Applicant: HOECHST AG

Inventor： HOPPE HANS-ULLRICH ,  GRABLEY SUSANNE ,  VOELSKOW HARTMUT ,  SCHLINGMANN MERTEN ,  KRAEMER HANS PETER ,  WIESNER MATTHIAS ,  THIEM JOACHIM

IPC: A61K31/42 ,  A61K31/47 ,  A61P31/04 ,  A61P33/02 ,  A61P35/02 ,  C07D498/06 ,  C07F7/18 ,  C07H15/252 ,  C07H17/00

公开(公告)号：FI84483B

公开(公告)日：1991-08-30

申请号：FI872094

申请日：1987-05-12

Applicant: HOECHST AG

Inventor： HOPPE HANS-ULLRICH ,  GRABLEY SUSANNE ,  VOELSKOW HARTMUT ,  SCHLINGMANN MERTEN ,  KRAEMER HANS PETER ,  WIESNER MATTHIAS ,  THIEM JOACHIM

IPC: A61K31/42 ,  A61K31/47 ,  A61P31/04 ,  A61P33/02 ,  A61P35/02 ,  C07D498/06 ,  C07F7/18 ,  C07H15/252 ,  C07H17/00

公开(公告)号：CA1269657A

公开(公告)日：1990-05-29

申请号：CA515622

申请日：1986-08-08

Applicant: HOECHST AG

Inventor： THIEM JOACHIM ,  DEGER HANS-MATTHIAS ,  FRITSCHE-LANG WOLFRAM ,  KREUZER MATTHIAS

IPC: B01J23/00 ,  B01J31/00 ,  C07B61/00 ,  C07H1/00 ,  C07H5/02 ,  C07H15/04 ,  C07H15/18 ,  C07H5/06

Abstract: Alkylated glycosyl fluorides free from hydroxyl groups can be prepared by converting glycosyl fluorides which still contain hydroxyl groups into the alkylated compounds in the manner of Williamson's ether synthesis in the presence of basic systems by means of alkylated agents. The alkylated glycosyl fluorides of the invention are suitable for use as starting compounds for the isolation of glycosides.

公开(公告)号：AU594764B2

公开(公告)日：1990-03-15

申请号：AU7278787

申请日：1987-05-13

Applicant: HOECHST AG

Inventor： HOPPE HANS-ULLRICH ,  GRABLEY SUSANNE ,  VOELSKOW HARTMUT ,  SCHLINGMANN MERTEN ,  KRAEMER HANS PETER ,  WIESNER MATTHIAS ,  THIEM JOACHIM

IPC: A61K31/42 ,  A61K31/47 ,  A61P31/04 ,  A61P33/02 ,  A61P35/02 ,  C07D498/06 ,  C07F7/18 ,  C07H15/252 ,  C07H17/00 ,  A61K31/44 ,  A61K31/445 ,  A61K31/695

公开(公告)号：FI872094A

公开(公告)日：1987-11-15

申请号：FI872094

申请日：1987-05-12

Applicant: HOECHST AG

Inventor： HOPPE HANS-ULLRICH ,  GRABLEY SUSANNE ,  VOELSKOW HARTMUT ,  SCHLINGMANN MERTEN ,  KRAEMER HANS PETER ,  WIESNER MATTHIAS ,  THIEM JOACHIM

IPC: A61K31/42 ,  A61K31/47 ,  A61P31/04 ,  A61P33/02 ,  A61P35/02 ,  C07D498/06 ,  C07F7/18 ,  C07H15/252 ,  C07H17/00 ,  C07D

公开(公告)号：DK243687A

公开(公告)日：1987-11-15

申请号：DK243687

申请日：1987-05-13

Applicant: HOECHST AG

Inventor： HOPPE HANS-ULLRICH ,  GRABLEY SUSANNE ,  VOELSKOW HARTMUT ,  SCHLINGMANN MERTEN ,  KRAEMER HANS PETER ,  WIESNER MATTHIAS ,  THIEM JOACHIM

IPC: A61K31/42 ,  A61K31/47 ,  A61P31/04 ,  A61P33/02 ,  A61P35/02 ,  C07D498/06 ,  C07F7/18 ,  C07H15/252 ,  C07H17/00

公开(公告)号：DK320685D0

公开(公告)日：1985-07-12

申请号：DK320685

申请日：1985-07-12

Applicant: HOECHST AG

Inventor： THIEM JOACHIM ,  FRITSCHE-LANG WOLFRAM ,  SCHLINGMANN MERTEN ,  DEGER HANS-MATTHIAS ,  KREUZER MATTHIAS

IPC: B01J27/00 ,  B01J27/12 ,  B01J27/135 ,  C07B61/00 ,  C07H1/00 ,  C07H15/04 ,  C07H15/18 ,  C07H15/20 ,  C07J75/00 ,  C07H

Abstract: A process for the manufacture of glycosides which comprises reacting a protected hexopyranosyl fluoride with an aglycon or a silyl ether thereof in the presence of a metal fluoride of group IV or V of the periodic table, said metal having an atomic number of at least 22 and being present in the fluoride in a higher, stable and non-oxidizing or weekly oxidizing stage.

公开(公告)号：CA1286288C

公开(公告)日：1991-07-16

申请号：CA536966

申请日：1987-05-13

Applicant: HOECHST AG

Inventor： HOPPE HANS-ULLRICH ,  GRABLEY SUSANNE ,  VOELSKOW HARTMUT ,  SCHLINGMANN MERTEN ,  KRAEMER HANS P ,  WIESNER MATTHIAS ,  THIEM JOACHIM

IPC: A61K31/42 ,  A61K31/47 ,  A61P31/04 ,  A61P33/02 ,  A61P35/02 ,  C07D498/06 ,  C07F7/18 ,  C07H15/252 ,  C07H17/00 ,  C07D498/04 ,  C07F7/10 ,  C07H15/26

Abstract: Streptazoline is reacted with naphthoquinones in a DielsAlder reaction, and the adduct is then oxidized. The resulting compounds have cytotoxic activity, in particular against leukemia cells, and have an antimicrobial action and act against protozoa.

公开(公告)号：CA1269660A

公开(公告)日：1990-05-29

申请号：CA518080

申请日：1986-09-12

Applicant: HOECHST AG

Inventor： THIEM JOACHIM ,  DEGER HANS-MATTHIAS ,  FRITSCHE-LANG WOLFRAM ,  KREUZER MATTHIAS

IPC: C07H5/02 ,  C07H13/04 ,  C07H15/18

Abstract: Glycosyl halides which are 0-acylated or 0-alkylated at least in the 2-position are transhalogenated with alkali metal hydrogen difluorides in a polar-aprotic solvent and, if appropriate, the product is anomerized with the addition of less than the stoichiometric amounts of an inorganic fluoride with a Lewis acid character. Depending on the substrate, the glycosyl fluorides with the 1,2-trans or 1,2-cis configuration are obtained. The glycosyl fluorides produced by the process of the invention are useful glycosylating agents in carbohydrate chemistry.