公开(公告)号：DK174730B1

公开(公告)日：2003-10-06

申请号：DK72289

申请日：1989-02-16

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  BLUMBACH JUERGEN

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/00 ,  C07D501/32 ,  C07D501/34

Abstract: Cephemcarboxylic acid esters of the general formula +TR pharmaceutical preparations which are active against bacterial infections, which contain such cephem derivatives, a process for the preparation of the cephem derivatives and the pharmaceutical preparations, and also the use of the cephem derivatives for combating bacterial infections.

公开(公告)号：PT94347B

公开(公告)日：1997-01-31

申请号：PT9434790

申请日：1990-06-12

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  DUERCKHEIMER WALTER ,  ISERT DIETER ,  MENCKE BURKHARD

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/00 ,  C07D501/34 ,  C07D501/56

Abstract: Crystalline cephem acid addition salts of the general formula II pharmaceutical preparations active against bacterial infections and which contain such cephem derivatives, process for preparing the cephem derivatives and the pharmaceutical preparations, and use of the cephem derivatives for controlling bacterial infections.

公开(公告)号：AU7095691A

公开(公告)日：1991-08-15

申请号：AU7095691

申请日：1991-02-12

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  DURCKHEIMER WALTER ,  HORLEIN ROLF ,  MENCKE BURGHARD

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/00 ,  C07D501/04 ,  C07D501/18 ,  C07D501/34

Abstract: Prepn. of cpd. of formula (I) comprises reacting of 7-amino-cephalosporanic acid of formula (II) or deriv. with a mixt. of MeOH, methanesulphonic acid (III) and trifluoromethanesulphonic acid (IV). Pref. (II) is used in the form of an aromatic sulphonic acid salt, esp. as the p-toluenesulphonic acid dihydrate or its anhydrous analogue. 7-40 equivs. of (III), 0.5-5 equivs. of (IV) and 2-20 equivs. of MeOH are used relative to (II).

公开(公告)号：NO910556A

公开(公告)日：1991-08-14

申请号：NO910556

申请日：1991-02-12

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  DUERCKHEIMER WALTER ,  HOERLEIN ROLF ,  MENCKE BURGHARD

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/00 ,  C07D501/04 ,  C07D501/18 ,  C07D501/34

CPC classification number: C07D501/00

公开(公告)号：ZA904526B

公开(公告)日：1991-03-27

申请号：ZA904526

申请日：1990-06-12

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  FRIEDHELM ADAM ,  MENCKE BURKHARD ,  BURKHARD MENCKE ,  DUERCKHEIMER WALTER ,  WALTER DUERCKHEIMER ,  ISERT DIETER ,  DIETER ISERT

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/00 ,  C07D501/34 ,  C07D501/56 ,  C07D ,  A61K

Abstract: Crystalline cephem acid addition salts of the general formula II pharmaceutical preparations active against bacterial infections and which contain such cephem derivatives, process for preparing the cephem derivatives and the pharmaceutical preparations, and use of the cephem derivatives for controlling bacterial infections.

公开(公告)号：AU5903790A

公开(公告)日：1991-01-17

申请号：AU5903790

申请日：1990-07-13

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  DURCKHEIMER WALTER ,  SCHEUNEMANN KARL-HEINZ ,  ISERT DIETER ,  SEIBERT GERHARD

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D277/36 ,  C07D277/56 ,  C07D501/00 ,  C07D501/36

Abstract: Cephalosporin derivatives of the general formula pharmaceutical preparations active against bacterial infections which contain such cephalosporin derivatives, processes for the preparation of the cephalosporin derivatives, use of the cephalosporin derivatives for the preparation of a pharmaceutical for combating bacterial infections, and starting products for the preparation of cephalosporin derivatives.

公开(公告)号：ZA9002381B

公开(公告)日：1990-12-28

申请号：ZA9002381

申请日：1990-03-28

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  FRIEDHELM ADAM ,  DUERCKHEIMER WALTER ,  WALTER DUERCKHEIMER ,  FISCHER GERD ,  GERD FISCHER ,  MENCKE BURKHARD ,  BURKHARD MENCKE ,  SEIBERT GERHARD ,  GERHARD SEIBERT ,  KLESEL NORBERT ,  NORBERT KLESEL ,  ISERT DIETER ,  DIETER ISERT

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/06 ,  C07D501/22 ,  C07D501/34 ,  C07D501/46 ,  C07D ,  A61K

CPC classification number: C07D501/34

公开(公告)号：HU903828D0

公开(公告)日：1990-11-28

申请号：HU382890

申请日：1990-06-13

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  DUERCKHEIMER WALTER ,  MENCKE BURKHARD ,  ISERT DIETER

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/00 ,  C07D501/34 ,  C07D501/56

Abstract: Crystalline cephem acid addition salts of the general formula II pharmaceutical preparations active against bacterial infections and which contain such cephem derivatives, process for preparing the cephem derivatives and the pharmaceutical preparations, and use of the cephem derivatives for controlling bacterial infections.

公开(公告)号：CA2013226A1

公开(公告)日：1990-09-29

申请号：CA2013226

申请日：1990-03-28

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  DURCKHEIMER WALTER ,  FISCHER GERD ,  MENCKE BURKHARD ,  SEIBERT GERHARD ,  ISERT DIETER ,  KLESEL NORBERT

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/06 ,  C07D501/22 ,  C07D501/34 ,  C07D501/46

Abstract: Cephalosporin derivatives of the general formula pharmaceutical preparations active against bacterial infections and which contain such cephem derivatives, a process for the preparation of the cephem derivatives and of the pharmaceutical preparations, and use of the cephem derivatives for the control of bacterial infections.

公开(公告)号：HU901893D0

公开(公告)日：1990-08-28

申请号：HU189390

申请日：1990-03-29

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  DUERCKHEIMER WALTER ,  FISCHER GERD ,  MENCKE BURKHARD ,  SEIBERT GERHARD ,  ISERT DIETER ,  KLESEL NORBERT

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/06 ,  C07D501/22 ,  C07D501/34 ,  C07D501/46

Abstract: Cephalosporin derivatives of the general formula pharmaceutical preparations active against bacterial infections and which contain such cephem derivatives, a process for the preparation of the cephem derivatives and of the pharmaceutical preparations, and use of the cephem derivatives for the control of bacterial infections.