公开(公告)号：AU4865993A

公开(公告)日：1994-04-14

申请号：AU4865993

申请日：1993-09-27

Applicant: HOECHST AG

Inventor： LAL BANSI DR ,  GIDWANI RAMESH MATIORAM DR ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN DR ,  ENGLERT HEINRICH DR ,  SCHOLZ WOLFGANG DR

IPC: A61K31/47 ,  A61K31/472 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12

Abstract: Described are guanidinocarbonyl isoquinolines I, with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their prepara-tion, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.

公开(公告)号：ES2152938T3

公开(公告)日：2001-02-16

申请号：ES93115081

申请日：1993-09-20

Applicant: HOECHST AG

Inventor： LAL BANSI DR ,  GIDWANI RAMESH MATIORAM DR ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN DR

IPC: A61K31/472 ,  A61P9/00 ,  A61P9/04 ,  A61K31/47 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12

Abstract: Described are guanidinocarbonyl isoquinolines I, with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their prepara-tion, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.

公开(公告)号：DK0590455T3

公开(公告)日：2001-01-22

申请号：DK93115081

申请日：1993-09-20

Applicant: HOECHST AG

Inventor： LAL BANSI DR ,  GIDWANI RAMESH MATIORAM DR ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN DR ,  ENGLERT HEINRICH DR ,  SCHOLZ WOLFGANG DR

IPC: A61K31/472 ,  A61P9/00 ,  A61K31/47 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12

Abstract: Described are guanidinocarbonyl isoquinolines I, with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their prepara-tion, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.

公开(公告)号：AT198328T

公开(公告)日：2001-01-15

申请号：AT93115081

申请日：1993-09-20

Applicant: HOECHST AG

Inventor： LAL BANSI DR ,  GIDWANI RAMESH MATIORAM DR ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN DR ,  ENGLERT HEINRICH DR ,  SCHOLZ WOLFGANG DR

IPC: A61K31/47 ,  A61K31/472 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12

Abstract: Described are guanidinocarbonyl isoquinolines I, with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their prepara-tion, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.

公开(公告)号：AU662079B2

公开(公告)日：1995-08-17

申请号：AU4865993

申请日：1993-09-27

Applicant: HOECHST AG

Inventor： LAL BANSI DR ,  GIDWANI RAMESH MATIORAM DR ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN DR ,  ENGLERT HEINRICH DR ,  SCHOLZ WOLFGANG DR

IPC: A61K31/47 ,  A61K31/472 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12

Abstract: Described are guanidinocarbonyl isoquinolines I, with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their prepara-tion, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.

公开(公告)号：GR3035537T3

公开(公告)日：2001-06-29

申请号：GR20010400378

申请日：2001-03-09

Applicant: HOECHST AG

Inventor： LAL BANSI DR ,  GIDWANI RAMESH MATIORAM DR ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN DR ,  ENGLERT HEINRICH DR ,  SCHOLZ WOLFGANG DR

IPC: A61K31/472 ,  A61P9/00 ,  A61K31/47 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12

Abstract: Described are guanidinocarbonyl isoquinolines I, with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their prepara-tion, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.