公开(公告)号：PT590455E

公开(公告)日：2001-04-30

申请号：PT93115081

申请日：1993-09-20

Applicant: HOECHST AG

Inventor： LANG HANS-JOCHEN ,  ENGLERT HEINRICH ,  LAL BANSI ,  WOLFGANG SCHOLZ DR ,  RAMESH MATIORAM GIDWANI DR ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI

IPC: A61K31/472 ,  A61P9/00 ,  A61K31/47 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12

Abstract: Described are guanidinocarbonyl isoquinolines I, with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their prepara-tion, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.

公开(公告)号：FI103884B1

公开(公告)日：1999-10-15

申请号：FI934185

申请日：1993-09-24

Applicant: HOECHST AG

Inventor： LAL BANSI ,  GIDWANI RAMESH MATIORAM ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN ,  ENGLERT HEINRICH ,  SCHOLZ WOLFGANG

IPC: A61K31/472 ,  A61P9/00 ,  A61P9/04 ,  A61K31/47 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12

Abstract: Described are guanidinocarbonyl isoquinolines I, with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their prepara-tion, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.

公开(公告)号：AU4865993A

公开(公告)日：1994-04-14

申请号：AU4865993

申请日：1993-09-27

Applicant: HOECHST AG

Inventor： LAL BANSI DR ,  GIDWANI RAMESH MATIORAM DR ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN DR ,  ENGLERT HEINRICH DR ,  SCHOLZ WOLFGANG DR

IPC: A61K31/47 ,  A61K31/472 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12

Abstract: Described are guanidinocarbonyl isoquinolines I, with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their prepara-tion, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.

公开(公告)号：NO933450A

公开(公告)日：1994-03-29

申请号：NO933450

申请日：1993-09-27

Applicant: HOECHST AG

Inventor： LAL BANSI ,  GIDWANI RAMESH MATIORAM ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN ,  ENGLERT HEINRICH CHRISTIAN ,  SCHOLZ WOLFGANG

IPC: A61K31/47 ,  A61K31/472 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12

CPC classification number: C07D401/04 ,  C07D217/26 ,  C07D413/04

公开(公告)号：PT88923B

公开(公告)日：1993-01-29

申请号：PT8892388

申请日：1988-11-03

Applicant: HOECHST AG

Inventor： KANNAN RAJESHWARI ,  LAL BANSI ,  RAJAGOPALAN RAMANUJAM ,  NOMANBHAIDOHADWALLA ALIHUSSEIN ,  RUPP RICHARD HELMUT ,  KHANDELWAL YATENDRA

IPC: A61K31/35 ,  A61K31/352 ,  A61P9/04 ,  A61P9/12 ,  A61P27/02 ,  C07D311/92 ,  C07F7/18 ,  A61K31/695

Abstract: Acyl-labdane derivatives of the formula a process for their preparation and the use of the substances as pharmaceutical agents, in particular as medicaments having activity against increased internal ocular pressure and increased blood pressure.

公开(公告)号：PT85302B

公开(公告)日：1990-03-30

申请号：PT8530287

申请日：1987-07-10

Applicant: HOECHST AG

Inventor： RAJAGOPALAN RAMANUJAM ,  SOUZA NOEL JOHN DE ,  NOMANBHAIDOHADWALLA ALIHUSSEIN ,  RUPP RICHARD HELMUT ,  KHANDELWAL YATENDRA

IPC: A61K31/35 ,  A61K31/352 ,  A61P9/12 ,  C07D311/92 ,  C07D405/12 ,  C07F7/18

Abstract: 7-Acyloxy-6-aminoacyloxypolyoxylabdanes and their physiologically acceptable salts have the pharmacological properties associated with the polyoxylabdane class, but in particular exhibit a pronounced selective hypotensive effect.

公开(公告)号：GR3035537T3

公开(公告)日：2001-06-29

申请号：GR20010400378

申请日：2001-03-09

Applicant: HOECHST AG

Inventor： LAL BANSI DR ,  GIDWANI RAMESH MATIORAM DR ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN DR ,  ENGLERT HEINRICH DR ,  SCHOLZ WOLFGANG DR

IPC: A61K31/472 ,  A61P9/00 ,  A61K31/47 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12

Abstract: Described are guanidinocarbonyl isoquinolines I, with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their prepara-tion, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.

公开(公告)号：DE69329787T2

公开(公告)日：2001-06-13

申请号：DE69329787

申请日：1993-09-20

Applicant: HOECHST AG

Inventor： LAL DR ,  GIDWANI DR ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG DR ,  ENGLERT DR ,  SCHOLZ DR

IPC: A61K31/472 ,  A61P9/00 ,  A61K31/47 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12

Abstract: Described are guanidinocarbonyl isoquinolines I, with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their prepara-tion, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.

公开(公告)号：ZA937141B

公开(公告)日：1994-05-18

申请号：ZA937141

申请日：1993-09-27

Applicant: HOECHST AG

Inventor： LAL BANSI ,  GIDWANI RAMESH MATIORAM ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  LANG HANS-JOCHEN ,  ENGLERT HEINRICH ,  SANKAR CHINNAKULANDAI ,  SCHOLZ WOLFGANG

IPC: A61K31/472 ,  A61P9/00 ,  A61K31/47 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12 ,  C07D ,  A61K

Abstract: Described are guanidinocarbonyl isoquinolines I, with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their prepara-tion, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.

公开(公告)号：PT92032A

公开(公告)日：1990-04-30

申请号：PT9203289

申请日：1989-10-19

Applicant: HOECHST AG

Inventor： BICKEL MARTIN ,  BLUMBACH JURGEN ,  LAL BANSI ,  RAJAGOPALAN RAMANUJAM ,  NOMANBHAIDOHADWALLA ALIHUSSEIN ,  RUPP RICHARD HELMUT ,  BAL-TEMBE SWATI ,  PUNEKAR NARAYAN SUDHINDRA

IPC: C07D295/08 ,  A61K31/445 ,  C07D211/36 ,  C07D295/088 ,  C07D295/092 ,  C07D211/00 ,  A61K31/435

Abstract: Compounds of the formula III in which R4 - R6 have the given meaning, have a spasmolytic activity.