公开(公告)号：DE59307409D1

公开(公告)日：1997-10-30

申请号：DE59307409

申请日：1993-06-28

Applicant: HOECHST AG

Inventor： BECK GERHARD DR ,  JENDRALLA JOACHIM-HEINER DR ,  KESSELER KURT DR

IPC: C07D319/06

公开(公告)号：AT156477T

公开(公告)日：1997-08-15

申请号：AT92107395

申请日：1992-04-30

Applicant: HOECHST AG

Inventor： LERCH ULRICH DR ,  JENDRALLA JOACHIM-HEINER DR ,  SEURING BERNHARD DR ,  HENNING RAINER DR

IPC: B01J31/24 ,  C07B61/00 ,  C07C231/02 ,  C07C231/18 ,  C07C233/14 ,  C07C233/22 ,  C07C233/40 ,  C07D211/44 ,  C07D211/58 ,  C07D241/04 ,  C07F9/572 ,  C07F15/00

Abstract: Two processes for the preparation of the optically pure compounds of the general formula 1 are described in which R and R are, for example, alkyl, R and R are, for example, hydrogen and R is, for example, hydrogen. Both processes include the enantioselective hydrogenation of a C=C double bond and the regioselective monoamide formation of a dicarboxylic acid derivative as key steps.

公开(公告)号：ES2097238T3

公开(公告)日：1997-04-01

申请号：ES92107396

申请日：1992-04-30

Applicant: HOECHST AG

Inventor： LERCH ULRICH DR ,  JENDRALLA JOACHIM-HEINER DR ,  SEURING BERNHARD DR ,  HENNING RAINER DR

IPC: C07F9/50 ,  C07C45/50 ,  C07F9/572 ,  C07F15/00

公开(公告)号：DE4422672A1

公开(公告)日：1996-01-04

申请号：DE4422672

申请日：1994-06-30

Applicant: HOECHST AG

Inventor： JENDRALLA JOACHIM-HEINER DR

IPC: B01J31/24 ,  C07B61/00 ,  C07F9/50 ,  C07F9/53 ,  C07F15/00 ,  C07B53/00 ,  C07D295/108

Abstract: Novel biphenyl-2,2'-diyl-bis diphenyl- phosphines of formulae (I) and (II) with the biphenyl rings in (I) opt. substd. by up to 8 F and/or Cl are claimed, as are also (i) prepn. of (I) and (II) by reaction in an org. solvent of a biphenyl phosphine oxide of formula (III) (opt. having up to 6 additional F and/or Cl on the biphenyl rings) with either (i) Cl2SiMeH and NBu3 or (ii) a refluxing mixt. of HSiCl3 and NBu3; (ii) cpd. (III) as a novel cpd.; (iii) prepn. of (III) and its intermediates; (iv) Rh(I)-, Ru(II)-, Pd(II)- and PD(O)- complexes of (I) and (II) and their use as catalysts, esp. for addn., substitution, adducting or coupling reactions; and (v) prepn. of the complexes (iv). X = F or Cl.

公开(公告)号：ES2184774T3

公开(公告)日：2003-04-16

申请号：ES95109922

申请日：1995-06-26

Applicant: HOECHST AG

Inventor： JENDRALLA JOACHIM-HEINER DR

IPC: B01J31/24 ,  C07B61/00 ,  C07F9/50 ,  C07F9/53 ,  C07F15/00

Abstract: Novel biphenyl-2,2'-diyl-bis diphenyl- phosphines of formulae (I) and (II) with the biphenyl rings in (I) opt. substd. by up to 8 F and/or Cl are claimed, as are also (i) prepn. of (I) and (II) by reaction in an org. solvent of a biphenyl phosphine oxide of formula (III) (opt. having up to 6 additional F and/or Cl on the biphenyl rings) with either (i) Cl2SiMeH and NBu3 or (ii) a refluxing mixt. of HSiCl3 and NBu3; (ii) cpd. (III) as a novel cpd.; (iii) prepn. of (III) and its intermediates; (iv) Rh(I)-, Ru(II)-, Pd(II)- and PD(O)- complexes of (I) and (II) and their use as catalysts, esp. for addn., substitution, adducting or coupling reactions; and (v) prepn. of the complexes (iv). X = F or Cl.

公开(公告)号：AT172713T

公开(公告)日：1998-11-15

申请号：AT92104085

申请日：1992-03-10

Applicant: HOECHST AG

Inventor： JENDRALLA JOACHIM-HEINER DR ,  JACOBI DETLEF DR ,  KAMMERMEIER BERNHARD DR

IPC: C07C229/00 ,  C07C269/06 ,  C07C271/20 ,  C07C271/22 ,  C07C315/04 ,  C07C317/44 ,  C07D217/16

Abstract: A method is described for the preparation of optically pure symmetric compounds of the formula I in which R , R and R are described in the description, with the simultaneous control of the four centres of chirality identified with .

公开(公告)号：ES2106104T3

公开(公告)日：1997-11-01

申请号：ES92107395

申请日：1992-04-30

Applicant: HOECHST AG

Inventor： LERCH ULRICH DR ,  JENDRALLA JOACHIM-HEINER DR ,  SEURING BERNHARD DR ,  HENNING RAINER DR

IPC: C07B61/00 ,  C07C231/02 ,  C07C231/18 ,  B01J31/24 ,  C07C233/14 ,  C07C233/22 ,  C07C233/40 ,  C07D211/44 ,  C07D211/58 ,  C07D241/04 ,  C07F9/572 ,  C07F15/00

Abstract: Two processes for the preparation of the optically pure compounds of the general formula 1 are described in which R and R are, for example, alkyl, R and R are, for example, hydrogen and R is, for example, hydrogen. Both processes include the enantioselective hydrogenation of a C=C double bond and the regioselective monoamide formation of a dicarboxylic acid derivative as key steps.

公开(公告)号：CZ282299B6

公开(公告)日：1997-06-11

申请号：CS154792

申请日：1992-05-22

Applicant: HOECHST AG

Inventor： DEFOSSA ELISABETH DR ,  FISCHER GERD DR ,  JENDRALLA JOACHIM-HEINER DR ,  LATTRELL RUDOLF DR ,  WOLLMANN THEODOR DR ,  ISERT DIETER DR

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07B57/00 ,  C07D417/12 ,  C07D501/00 ,  C07D501/12 ,  C07D501/18 ,  C07D501/32 ,  C07D501/34

Abstract: The invention relates to crystalline acid addition salts of the two diastereomers of the 1-(2,2-dimethylpropionyloxy)ethyl ester of 3-cephem-4-carboxylic acid of the general formula II in which X represents the anion of a physiologically acceptable, mono- or polybasic, inorganic or organic acid and the group =N-OH is in the syn position, pharmaceutical preparations active against bacterial infections and which contain such cephem derivatives, a process for the preparation of the cephem derivatives, and the use of the cephem derivatives for the control of bacterial infections.

公开(公告)号：GR3022548T3

公开(公告)日：1997-05-31

申请号：GR970400238

申请日：1997-02-12

Applicant: HOECHST AG

Inventor： LERCH ULRICH DR ,  JENDRALLA JOACHIM-HEINER DR ,  SEURING BERNHARD DR ,  HENNING RAINER DR

IPC: C07F9/50 ,  C07C45/50 ,  C07F9/572 ,  C07F15/00

公开(公告)号：CZ9203044A3

公开(公告)日：1993-05-12

申请号：CS304492

申请日：1992-10-06

Applicant: HOECHST AG

Inventor： JACOBI DETLEF DR ,  JENDRALLA JOACHIM-HEINER DR ,  KAMMERMEIER BERNHARD DR

IPC: C07C229/00 ,  C07C213/00 ,  C07C215/18 ,  C07C269/00 ,  C07C269/06 ,  C07C271/16 ,  C07C271/20 ,  C07C271/22 ,  C07C315/04 ,  C07C317/44 ,  C07C317/50 ,  C07D217/12 ,  C07D217/16 ,  C07D217/18 ,  C07H15/04

CPC classification number: C07C271/20 ,  C07C213/00 ,  C07C269/00 ,  C07C271/22 ,  C07C315/04 ,  C07D217/16 ,  C07D217/18 ,  C07C317/44