公开(公告)号：KR800001398B1

公开(公告)日：1980-12-02

申请号：KR760003232

申请日：1976-12-30

Applicant: HOECHST AG

Inventor： KAISER J ,  LATRELL R ,  BARTMANN W

IPC: A61K31/40 ,  C07D209/12

Abstract: The indole derivs. (I; R1 = pyrrolidino, piperidino, 4-hexamethyleneimino, morphorino, 4-hydroxypiperidino, 4-carbethoxy-piperidino, 1-piperaziny1; R2 = H, pyrrolidino, hexamethylene-imino, 4-hydroxypiperidino, morpholino, 1-piperazinyl; R3 = H, 6-methoxy; m= 1-2; R4 = H, Me, Ph, benzyl, alkoxypheny1), useful as hypotensive and antiarrhythmics, were prepd. by reaction of II(R = Cl, Br) and HNR5R6(R5, R6 = C1-6 alkyl). Thus, 51.2g II(R = Cl) was refluxed with 172g anhydrous piperazine in 500ml dioxane to give 46g 1-pheny1-2-piperazino-3-indole carbaldehyde.

公开(公告)号：NZ198308A

公开(公告)日：1984-03-30

申请号：NZ19830881

申请日：1981-09-08

Applicant: HOECHST AG

Inventor： KONZ E ,  HOCK F ,  KAISER J ,  KRUSE H

IPC: C07D217/14 ,  A61K31/47 ,  A61K31/495 ,  A61K31/505 ,  A61K31/55 ,  A61P9/12 ,  A61P25/00 ,  C07D217/22 ,  C07D401/04 ,  C07D401/12 ,  C07D405/02 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D401 ,  C07D405 ,  C07D409

Abstract: New isoquinoline derivatives of the general formula (I) and their physiologically acceptable salts, which exert pharmacological actions on the central nervous system and the heart circulation system, a process for the preparation of these compounds, medicaments containing them, and their use as neuroleptic, antihypertonic and antiarrhythmic agents, are described.

公开(公告)号：NZ182908A

公开(公告)日：1979-08-31

申请号：NZ18290876

申请日：1976-12-17

Applicant: HOECHST AG

Inventor： KAISER J ,  BARTMANN W ,  LATTRELL R

IPC: C07D209/40 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61P9/06 ,  A61P9/12 ,  C07D209/42 ,  C07D401/12 ,  C07D405/12

公开(公告)号：ZA767522B

公开(公告)日：1977-11-30

申请号：ZA767522

申请日：1976-12-17

Applicant: HOECHST AG

Inventor： KAISER J ,  LATTRELL R ,  BARTMANN W

IPC: C07D209/40 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61P9/06 ,  A61P9/12 ,  C07D209/42 ,  C07D401/12 ,  C07D405/12 ,  C07D ,  A61K

公开(公告)号：DK571476A

公开(公告)日：1977-06-20

申请号：DK571476

申请日：1976-12-17

Applicant: HOECHST AG

Inventor： LATTRELL R ,  BARTMANN W ,  KAISER J

IPC: C07D209/40 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61P9/06 ,  A61P9/12 ,  C07D209/42 ,  C07D401/12 ,  C07D405/12 ,  C07D

公开(公告)号：SE386673B

公开(公告)日：1976-08-16

申请号：SE7314785

申请日：1973-10-31

Applicant: HOECHST AG

Inventor： KAMPE K-D ,  BABEJ M ,  KAISER J

IPC: C07B31/00 ,  C07B57/00 ,  C07C67/00 ,  C07D263/28 ,  C07D263/52 ,  C07D263/58 ,  C07D263/60

Abstract: New 2-amino-2-oxazolines and their salts with physiologically tolerated acids which may be used as medicaments, in particular as antihypotonics, diuretics or antiphlogistics, and process for preparing them.

公开(公告)号：FI304674A

公开(公告)日：1975-04-21

申请号：FI304674

申请日：1974-10-17

Applicant: HOECHST AG

Inventor： KUNSTMANN R ,  KAISER J

IPC: C07D217/22 ,  C07D401/04 ,  C07D471/10 ,  C07D

公开(公告)号：NZ220099A

公开(公告)日：1989-05-29

申请号：NZ22009987

申请日：1987-04-27

Applicant: HOECHST AG

Inventor： LERCH U ,  HENNING R ,  KAISER J

IPC: A61K31/54 ,  A61K31/5415 ,  A61P3/00 ,  A61P3/14 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D279/16 ,  C07D417/12

Abstract: Benzothiazinone derivatives I (I) with R1 and R4 being H, alkyl, alkoxy, Hal, CF3, NO2, OH, acetamido or amino, R2 being H, (cyclo)alk(en)yl, cycloalkylakyl, phenyl or phenylalkyl, A being (CH2)mO(CH2)n, (CH2)p-CH(OH)-CH2)q, (CH2)p-CH(OCH3)-(CH2)q, or (CH2)rOCH2-CO- and (CH2)s-CO-, R5 being NR(6)R(7) or certain cyclic amines, show a calcium-antagonistic action. They are obtained, inter alia, from II (II) by reaction with III IIIa IIIb IIIc IIId IIIe A and B are same or different and are lower alkylene having 1 to 6 carbon atoms; and n is 3 to 4.

公开(公告)号：DK139679C

公开(公告)日：1979-10-22

申请号：DK547874

申请日：1974-10-18

Applicant: HOECHST AG

Inventor： KUNSTMANN R ,  KAISER J

IPC: C07D217/22 ,  C07D401/04 ,  C07D471/10 ,  C07D215/16 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06 ,  C07D487/10

公开(公告)号：ZA7607522B

公开(公告)日：1977-11-30

申请号：ZA7607522

申请日：1976-12-17

Applicant: HOECHST AG

Inventor： KAISER J ,  LATTRELL R ,  BARTMANN W

IPC: C07D209/40 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61P9/06 ,  A61P9/12 ,  C07D209/42 ,  C07D401/12 ,  C07D405/12 ,  C07D ,  A61K

CPC classification number: C07D209/42 ,  Y10S514/821