公开(公告)号：KR820002385B1

公开(公告)日：1982-12-29

申请号：KR790001318

申请日：1979-04-25

Applicant: HOECHST AG

Inventor： BARTMANN W ,  KONZ E ,  GEYER H

IPC: C07D217/22

Abstract: Isoquinolines I(R1 = amino group -N(R4)(R5); R4, R5 = alky1 and make 5-8 membered cycle with N; R2 = halogen, OH, nitro, amino, substituted amino, mono- or di-substituted pheny1, pyridy1 or thieny1; R3 = H, OH, halogen, C1-6 alky1, alkoxy, NO2, amino, ethylenedioxy; m = 1,2), exhibiting effective activities for melancholia, were prepd. by reacting compds. II (X = H, carboxy1; Y = cl, Br) with amines (III). Thus, 3-chloro-1-pheny1-isoquinoline-4-carboxylic acid was heated to 150oC in N-methy1-piperazine and maintained for 6 hr to give 3-N-methy1piperazino-1-pheny1-isoquinoline.

公开(公告)号：ZA7805414B

公开(公告)日：1979-09-26

申请号：ZA7805414

申请日：1978-09-25

Applicant: HOECHST AG

Inventor： BARTMANN W ,  LERCH U ,  KONZ E ,  SCHOELKENS B

IPC: C07D307/935 ,  A61K31/34 ,  A61K31/343 ,  A61P9/00 ,  C07D307/937 ,  C07D ,  A61K

CPC classification number: C07D307/937

公开(公告)号：NZ198308A

公开(公告)日：1984-03-30

申请号：NZ19830881

申请日：1981-09-08

Applicant: HOECHST AG

Inventor： KONZ E ,  HOCK F ,  KAISER J ,  KRUSE H

IPC: C07D217/14 ,  A61K31/47 ,  A61K31/495 ,  A61K31/505 ,  A61K31/55 ,  A61P9/12 ,  A61P25/00 ,  C07D217/22 ,  C07D401/04 ,  C07D401/12 ,  C07D405/02 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D401 ,  C07D405 ,  C07D409

Abstract: New isoquinoline derivatives of the general formula (I) and their physiologically acceptable salts, which exert pharmacological actions on the central nervous system and the heart circulation system, a process for the preparation of these compounds, medicaments containing them, and their use as neuroleptic, antihypertonic and antiarrhythmic agents, are described.

公开(公告)号：ZA8000441B

公开(公告)日：1981-01-28

申请号：ZA8000441

申请日：1980-01-24

Applicant: HOECHST AG

Inventor： SCHOELKENS B ,  KONZ E ,  BARTMANN W ,  LERCH U

IPC: C07D307/935 ,  A61K31/34 ,  A61K31/343 ,  A61K31/557 ,  A61P7/02 ,  C07D307/937 ,  C07D

CPC classification number: C07D307/937

公开(公告)号：ZA793991B

公开(公告)日：1980-08-27

申请号：ZA793991

申请日：1979-08-03

Applicant: HOECHST AG

Inventor： KONZ E ,  LERCH U ,  BARTMANN W ,  BECK G

IPC: A61K31/21 ,  A61K31/19 ,  A61P43/00 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D317/54 ,  C07D317/72 ,  C07D319/06 ,  C07D319/08 ,  C07C

公开(公告)号：NZ205513A

公开(公告)日：1986-05-09

申请号：NZ20551383

申请日：1983-09-07

Applicant: HOECHST AG

Inventor： KONZ E ,  KAISER J

IPC: A61K31/395 ,  A61K31/47 ,  A61K31/472 ,  A61P9/06 ,  C07D217/26 ,  C07D401/12 ,  C07D413/12 ,  C07D471/12 ,  C07D491/056 ,  C07D217/00 ,  C07D401/00

Abstract: Isoquinoline-4-carboxylic acid derivatives of the formula I I in which m, n, R1, R2, R3, A and X have the meansings indicated, and physiologically acceptable acid addition salts thereof, a process for their preparation, pharmaceutical formulations based on these compounds and the use thereof as antiarrythmic agents.

公开(公告)号：ZA7901266B

公开(公告)日：1980-03-26

申请号：ZA7901266

申请日：1979-03-16

Applicant: HOECHST AG

Inventor： KONZ E ,  SCHOELKENS B ,  BARTMANN W ,  LERCH U

IPC: C07D307/935 ,  A61K31/34 ,  A61K31/343 ,  A61K31/557 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D307/937 ,  C07D ,  A61K

CPC classification number: C07D307/937

公开(公告)号：DK170679A

公开(公告)日：1979-10-28

申请号：DK170679

申请日：1979-04-25

Applicant: HOECHST AG

Inventor： BARTMANN W ,  KONZ E ,  GEYER H M

IPC: A61K31/47 ,  A61K31/472 ,  A61P25/08 ,  A61P25/24 ,  A61P25/26 ,  C07D217/22 ,  C07D401/04 ,  C07D403/04 ,  C07D409/14 ,  C07D

公开(公告)号：ZA785414B

公开(公告)日：1979-09-26

申请号：ZA785414

申请日：1978-09-25

Applicant: HOECHST AG

Inventor： BARTMANN W ,  LERCH U ,  KONZ E ,  SCHOELKENS B

IPC: C07D307/935 ,  A61K31/34 ,  A61K31/343 ,  A61P9/00 ,  C07D307/937 ,  C07D ,  A61K

公开(公告)号：ZA80441B

公开(公告)日：1981-01-28

申请号：ZA80441

申请日：1980-01-24

Applicant: HOECHST AG

Inventor： SCHOELKENS B ,  KONZ E ,  BARTMANN W ,  LERCH U

IPC: C07D307/935 ,  A61K31/34 ,  A61K31/343 ,  A61K31/557 ,  A61P7/02 ,  C07D307/937 ,  C07D

Abstract: What is disclosed are prostacyclin analogs of the general formula I I which have a more specific action and/or a longer action than the naturally occurring prostacyclin PGI2, as well as intermediate products for their preparation and a process for their preparation. The compounds of formula I are distinguished by inhibitory action on thrombocyte aggregation and by relaxation of the vascular walls, in particular of the coronary arteries. They can thus be used as medicaments.