公开(公告)号：AT29728T

公开(公告)日：1987-10-15

申请号：AT84109101

申请日：1984-08-01

Applicant: HOECHST AG

Inventor： KESSLER HORST PROF DR ,  KUTSCHER BERNHARD ,  OBERMEIER RAINER DR ,  MUELLNER HUBERT DR

IPC: C07K7/00 ,  A61K37/02

公开(公告)号：DE3401545A1

公开(公告)日：1985-02-14

申请号：DE3401545

申请日：1984-01-18

Applicant: HOECHST AG

Inventor： KESSLER HORST PROF DR ,  KUTSCHER BERNHARD ,  OBERMAIER RAINER DR ,  MUELLNER HUBERT DR

IPC: A61K38/00 ,  C07K7/00 ,  C07K14/66 ,  C07C103/52 ,  A61K37/02 ,  A61K45/05 ,  C07C102/00

公开(公告)号：ES2054734T3

公开(公告)日：1994-08-16

申请号：ES88108485

申请日：1988-05-27

Applicant: HOECHST AG

Inventor： KOLAR CENEK DR ,  KESSLER HORST PROF DR ,  KOTTENHAHN MATTHIAS ,  KLING ANDREAS

IPC: C07H15/04 ,  A61K31/70 ,  A61K31/7028 ,  A61P43/00 ,  C07K1/02 ,  C07K1/113 ,  C07K9/00 ,  A61K37/02 ,  A61K37/64

公开(公告)号：DE3718181A1

公开(公告)日：1988-12-15

申请号：DE3718181

申请日：1987-05-29

Applicant: HOECHST AG

Inventor： KOLAR CENEK DR ,  KESSLER HORST PROF DR ,  KOTTENHAHN MATTHIAS ,  KLING ANDREAS

IPC: C07H15/04 ,  A61K31/70 ,  A61K31/7028 ,  A61P43/00 ,  C07K1/02 ,  C07K1/113 ,  C07K9/00 ,  C07H15/18 ,  C07H15/26

公开(公告)号：DE3880021D1

公开(公告)日：1993-05-13

申请号：DE3880021

申请日：1988-05-27

Applicant: HOECHST AG

Inventor： KOLAR CENEK DR ,  KESSLER HORST PROF DR ,  KOTTENHAHN MATTHIAS ,  KLING ANDREAS

IPC: C07H15/04 ,  A61K31/70 ,  A61K31/7028 ,  A61P43/00 ,  C07K1/02 ,  C07K1/113 ,  C07K9/00 ,  A61K37/02 ,  A61K37/64

Abstract: Glycosylated amino acids and peptides of formula (I) are new. R1 = Me or CH2OR2; R2 = each H or a protecting gp. conventionally used in carbohydrate chemistry; A = a hydroxyamino acid; X = H or halogen; Y = H, an urethane protecting gp. or one or more opt. protected amino acids; W = OH, a carboxyl protecting gp. or one or more opt. protected amino acids; providing that there are 1-20 amino acids present in (I).

公开(公告)号：AT87939T

公开(公告)日：1993-04-15

申请号：AT88108485

申请日：1988-05-27

Applicant: HOECHST AG

Inventor： KOLAR CENEK DR ,  KESSLER HORST PROF DR ,  KOTTENHAHN MATTHIAS ,  KLING ANDREAS

IPC: C07H15/04 ,  A61K31/70 ,  A61K31/7028 ,  A61P43/00 ,  C07K1/02 ,  C07K1/113 ,  C07K9/00 ,  A61K37/02 ,  A61K37/64

公开(公告)号：DE3703159A1

公开(公告)日：1988-08-11

申请号：DE3703159

申请日：1987-02-03

Applicant: HOECHST AG

Inventor： KESSLER HORST PROF DR ,  HAUPT ANDREAS DR ,  SCHUDOK MANFRED

IPC: A61K38/00 ,  C07K7/06 ,  C07K14/655 ,  C07K7/64 ,  A61K37/02 ,  C07K1/06

Abstract: The invention relates to cyclic hexapeptides of the general formula I and cyclic dimeric hexapeptides of the general formula II in which R is Thr, Val, Ala or Phe; S is Lys, Orn, C IDENTICAL C-CH2-NH2 or CH2-C IDENTICAL C-CH2-NH2; T is Trp; U is Phe, Phe(p-NHZ) or Tyr, which can optionally be esterified; V is D-Pro or D-Ala; W is Phe or Phe(p-NHZ); X is H, Z, COC6H5, COC6H4(p-N3) or CO-(CH2)n-C6H 4(p-OSO3Na) Y is CO(CH2)n where a max. of 3 CH2 groups can be replaced by O, CO, CO-C6H4(p-CO), CO-O-(CH2CH2-O-)mCO or CO-C IDENTICAL C-CO, CO(CH=CH)nCO, to a process for their preparation and to their use as medicines.

公开(公告)号：DE3614904A1

公开(公告)日：1987-11-05

申请号：DE3614904

申请日：1986-05-02

Applicant: HOECHST AG

Inventor： KESSLER HORST PROF DR ,  HAUPT ANDREAS DR ,  SCHUDOK MANFRED

IPC: C07K5/10 ,  A61K38/00 ,  A61P1/00 ,  A61P1/16 ,  C07K1/06 ,  C07K1/113 ,  C07K7/06 ,  C07K7/64 ,  C07K14/575 ,  C07K14/655 ,  A61K37/02 ,  C07K3/04

Abstract: The invention relates to cyclic hexapeptides of the general formula I and cyclic dimeric hexapeptides of the general formula II in which R = Thr or Val; S = Lys or Orn; T = Trp; U = Phe or Phe(p-NHZ); V = D-Pro or D-Ala; W = Phe or Phe(p-NHZ); X = H, Z, COC6H5 or COC6H4(p-N3); and Y = CO(CH2)nCO or CO-O-(CH2-CH2-O)m-CO. A process for preparing these compounds and their use are described.

公开(公告)号：DE3466225D1

公开(公告)日：1987-10-22

申请号：DE3466225

申请日：1984-08-01

Applicant: HOECHST AG

Inventor： KESSLER HORST PROF DR ,  KUTSCHER BERNHARD ,  OBERMEIER RAINER DR ,  MULLNER HUBERT DR

IPC: A61K38/00 ,  C07K7/00 ,  C07K14/66 ,  A61K37/02

公开(公告)号：DE3324826A1

公开(公告)日：1985-01-17

申请号：DE3324826

申请日：1983-07-09

Applicant: HOECHST AG

Inventor： DAMM INGRID ,  KESSLER HORST PROF DR ,  RAO GOVID S PROF DR ,  USADEL KLAUS-HENNING PROF DR

IPC: A61K38/00 ,  C07K7/64 ,  C07C103/52 ,  A61K37/02

Abstract: The invention relates to cyclic hexapeptides of the general formula I U-Lys-V-W-X-Y in which U denotes Val or Thr, V denotes Trp or (5-F)Trp, each in the D- or L-form, W denotes Phe, Tyr or Phe(OR), X denotes Phe(OR) or Pro, each in the D- or L-form, and Y denotes Phe, Phe(Cl), Phe(OR) or, if X = Phe or Phe(OR), also denotes Pro, where R represents hydrogen or alkyl, processes for their preparation, as well as intermediates and processes for their preparation.