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1.发明专利
公开(公告)号：CA1270100A
公开(公告)日：1990-06-05
申请号：CA521657
申请日：1986-10-28
Applicant: HOECHST AG
Inventor： KESSLER HORST , KUTSCHER BERNHARD , OBERMEIER RAINER , MUELLNER HUBERT
Abstract: The invention relates to peptides of the formula II in which W represents Lys (R1), D-lys (R1), Arg (R2) or D-Arg (R2), X represents Lys (R1), D-Lys (R1), Arg (R2) or D-Arg (R2), Y represents Asp (R3), D-Asp (R3), Glu (R3) or D-Glu (R3), U represents Val or D-Val, D represents Tyr, D-Tyr, Trp, D-Trp, Phe or D-Phe, and in which R1 represents a urethane-protective group, R2 represents a protective group for the guanidino function and R3 represents an ester-protective group, and wherein (a) all five radicals a represent peptide bonds or (b) one of the radicals a represents a C-terminal OH together with an N-terminal H (a=OH H-) of two aminoacid radicals and the remaining four radicals a each denote peptide bonds, and processes for their preparation and their use. The peptides of the invention can be used for the synthesis of peptides of the Formula I. The latter can be used for the treatment of immunodeficiencies, viral, fungoidal and chronic bacterial infections and autoimmune diseases and for the therapy of diseases which are caused by cells with immunologically relevant changes in the cell membrane characteristics (for example tumor cells).
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公开(公告)号：AU572174B2
公开(公告)日：1988-05-05
申请号：AU3145984
申请日：1984-08-02
Applicant: HOECHST AG
Inventor： KESSLER HORST , KUTSCHER BERNHARD , OBERMEIER RAINER , MULLNER HUBERT
IPC: A61K38/00 , C07K7/00 , C07K14/66 , C07C103/52
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公开(公告)号：DE3466225D1
公开(公告)日：1987-10-22
申请号：DE3466225
申请日：1984-08-01
Applicant: HOECHST AG
Inventor： KESSLER HORST PROF DR , KUTSCHER BERNHARD , OBERMEIER RAINER DR , MULLNER HUBERT DR
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4.发明专利
公开(公告)号：ZA8405982B
公开(公告)日：1985-03-27
申请号：ZA8405982
申请日：1984-08-02
Applicant: HOECHST AG
Inventor： KESSLER HORST , KUTSCHER BERNHARD , OBERMEIER RAINER , MUELLNER HUBERT
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公开(公告)号：AU3145984A
公开(公告)日：1985-02-07
申请号：AU3145984
申请日：1984-08-02
Applicant: HOECHST AG
Inventor： KESSLER HORST , MULLNER HUBERT , KUTSCHER BERNHARD , OBERMEIER RAINER
IPC: A61K38/00 , C07K7/00 , C07K14/66 , C07C103/52
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Patent Agency Ranking6.发明专利
公开(公告)号：CA1237713A
公开(公告)日：1988-06-07
申请号：CA460240
申请日：1984-08-02
Applicant: HOECHST AG
Inventor： KESSLER HORST , KUTSCHER BERNHARD , OBERMEIER RAINER , MUELLNER HUBERT
Abstract: of the disclosure: The invention relates to cyclopeptides of the formula I (I) in which A denotes Lys, D-Lys, Arg or D-Arg, B denotes Lys, D-Lys, Arg or D-Arg, C denotes Asp, D-Asp, Glu or D-Glu, U denotes Val or D-Val and D denotes Tyr, D-Tyr, Trp, D-Trp, Phe or D-Phe, 1 to 4 of the radicals A, B, C, U and D being in the D-configuration and the remaining radicals being in the D-configuration, processes for their preparation, their use and peptidic precursors and processes for their preparation.
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7.发明专利
公开(公告)号：AT29728T
公开(公告)日：1987-10-15
申请号：AT84109101
申请日：1984-08-01
Applicant: HOECHST AG
Inventor： KESSLER HORST PROF DR , KUTSCHER BERNHARD , OBERMEIER RAINER DR , MUELLNER HUBERT DR
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公开(公告)号：DE3401545A1
公开(公告)日：1985-02-14
申请号：DE3401545
申请日：1984-01-18
Applicant: HOECHST AG
Inventor： KESSLER HORST PROF DR , KUTSCHER BERNHARD , OBERMAIER RAINER DR , MUELLNER HUBERT DR
IPC: A61K38/00 , C07K7/00 , C07K14/66 , C07C103/52 , A61K37/02 , A61K45/05 , C07C102/00
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9.发明专利
公开(公告)号：ZA845982B
公开(公告)日：1985-03-27
申请号：ZA845982
申请日：1984-08-02
Applicant: HOECHST AG
Inventor： KESSLER HORST , KUTSCHER BERNHARD , OBERMEIER RAINER , MUELLNER HUBERT
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公开(公告)号：DK375684D0
公开(公告)日：1984-08-02
申请号：DK375684
申请日：1984-08-02
Applicant: HOECHST AG
Inventor： KESSLER HORST , KUTSCHER BERNHARD , OBERMAIER RAINER , MUELLNER HUBERT
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