公开(公告)号：KR780000095B1

公开(公告)日：1978-04-08

申请号：KR730000464

申请日：1973-03-22

Applicant: HOECHST AG

Inventor： DITTMAR W ,  LOHAUS G

IPC: C07D221/04 ,  A61K31/4412 ,  A61P31/04 ,  C07D213/64 ,  C07D213/89 ,  C07D221/10 ,  C07D221/20 ,  C07D405/04 ,  C07D405/06

公开(公告)号：US3746765A

公开(公告)日：1973-07-17

申请号：US3746765D

申请日：1971-08-05

Applicant: HOECHST AG

Inventor： RUSCHIG H ,  KOENIG J ,  DUWEL D ,  DITTMAR W ,  KLATT P

IPC: C07C235/84 ,  A61K20060101 ,  A61K31/00 ,  A61K31/16 ,  A61K31/165 ,  A61K31/18 ,  C07C20060101 ,  C07C233/00 ,  C07C233/12 ,  C07C327/38 ,  C07C103/86 ,  C07C153/05

CPC classification number: C07C265/12

Abstract: A COMPOUND OF FORMULA I

(2,6-DI(O=)CYCLOHEXYL)-C(=X)-NH-C6H3(-R1)-R2

IN WHICH X REPRESENTS ORYGEN OR SULFUR, R1 REPRESENTS HALOGEN, TRIFLUOROMETHYL, NITRO, ALKYL OF 1 TO 4 CARBON ATOMS, ALKOXY OF 1 TO 4 CARBON ATOMS OR HALOGEN-ALKOXY OF 1 TO 4 CARBON ATOMS, OR, IF X STANDS FOR SULFUR, R1 STANDS FOR HYDROGEN, AND R2 REPRESENTS HYDROGEN OR THE SUBSTITUENTS GIVEN FOR R1, WICH COMPOUND HAS INTERESTING CHEMOTHERAPEUTICAL PROPERTIES AND IS EFFECTIVE AGAINST INTESTINAL WORMS AS HELMINTHS, ESPECIALLY AGAINST LIVER FLUKES. BECAUSE OF THEIR ANTIMYCOTIC PROPERTIES, THE COMPOUNDS OF THE INVENTION MAY ALSO BE USED IN HUMAN MEDICINE AND IN VETERINARY MEDICINE TO ATTACK FUNGUS INFECTIONS.

公开(公告)号：US3806530A

公开(公告)日：1974-04-23

申请号：US26986772

申请日：1972-07-07

Applicant: HOECHST AG

Inventor： DITTMAR W ,  DORFELT C ,  FISCHER K

IPC: C07F7/22

CPC classification number: C07F7/2244

Abstract: WHEREIN R1, R2, R3 AND R4 ARE INDENTICAL OR DIFFERENT AND REPRESENT ALKYL RADICALS HAVING 1 TO 8 CARBON ATOMS, PHENYL RADICALS OR PHENYL RADICALS SUBSTITUTED BY LOWER ALKYL RADICALS AND R5 REPRESENTS HYDROGEN OR THE METHYL GROUP AND THE USE OF THESE COMPOUNDS FOR THE ANTIMICROBIAL FINISHING OF TEXTILES.

CYCLOBUTANE

1,1,2,2-TETRA(F-),3-(R1-SN(-R2)(-R3)-OOC-C(-R5)=CH-),4-R4-

TIN-ORGANIC COMPOUNDS OF THE FORMULA 1

公开(公告)号：NZ217637A

公开(公告)日：1990-02-26

申请号：NZ21763786

申请日：1986-09-19

Applicant: HOECHST AG

Inventor： SIEGEL H ,  KAMPE K-D ,  ALPERMANN H G ,  GERHARDS H J ,  USINGER P ,  SCHACHT U ,  LEVEN M ,  RAETHER W ,  DITTMAR W ,  SACHSE B

IPC: A61K31/41 ,  A61K31/415 ,  C07D233/60 ,  C07D233/64 ,  C07D249/08 ,  C07D521/00 ,  C07D405/06

Abstract: Arylmethylazoles of the formula I I in which Aryl is (substituted) phenyl or naphthyl; Z is CH or N; R1 and Q are H or alkyl; R2 is H, alk(en)yl or alkynyl; R3 and R4 are H, alkyl or other hydrocarbons; or R3 and R4 together are a -(CH2)2-11 chain or a bridged -(CH2)4-5 chain, and their acid addition salts, stereoisomers and optically active enantiomers possess outstanding antimycotic and antidepressant activity. They are obtained, inter alia, from arylmethylazoles II II which are reacted with a strong base and then with a carbonyl compound III O=CR3R4; thereafter, the product is reacted with the protic acid or with an alkyl halide IV R2Hal. If desired, the products are converted to the acid addition salts, or the stereoisomers or optically active enantiomers are resolved.

公开(公告)号：ZA7302042B

公开(公告)日：1974-01-30

申请号：ZA7302042

申请日：1973-03-23

Applicant: HOECHST AG

Inventor： DITTMAR W ,  LOHAUS G

IPC: C07D221/04 ,  A61K31/4412 ,  A61P31/04 ,  C07D213/64 ,  C07D213/89 ,  C07D221/10 ,  C07D221/20 ,  C07D405/04 ,  C07D405/06 ,  C07D

CPC classification number: C07D213/89 ,  C07D221/10 ,  C07D221/20

公开(公告)号：NZ219605A

公开(公告)日：1989-04-26

申请号：NZ21960587

申请日：1987-03-13

Applicant: HOECHST AG

Inventor： EHRHARDT H ,  BLUME E ,  RAETHER W ,  DITTMAR W

IPC: C07C41/00 ,  A01N43/50 ,  A01N43/653 ,  A61K31/12 ,  A61K31/13 ,  A61K31/41 ,  A61K31/495 ,  C07C49/175 ,  C07C49/84 ,  C07C67/00 ,  C07C201/00 ,  C07C205/59 ,  C07C213/00 ,  C07D213/70 ,  C07D233/56 ,  C07D233/60 ,  C07D239/38 ,  C07D249/08 ,  C07D295/10 ,  C07D295/116 ,  C07D307/38 ,  C07D333/28 ,  C07D401/14 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D521/00 ,  C07D231/12 ,  C07D295/04 ,  A61K31/45 ,  A61K31/00

Abstract: Compounds I where A equals t-butyl, phenyl, biphenylyl, phenoxyphenyl, benzylphenyl, benzyloxyphenyl, phenylthiophenyl, phenylsulfinylphenyl, phenylsulfonylphenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, indanyl, fluorenyl, thienyl, furyl, pyridyl, isoxazolyl, pyrazolyl, benzofuryl or benzothienyl, Z equals CO, CH2 or radicals of ketone derivatives; Y equals azole or equals -X-R8 (R8=(cyclo)alkyl or an aromatic) or equals a number of amine derivatives or equal acyl, are antimycotics. The preparation and use as medicaments are described.

公开(公告)号：ZA7605434B

公开(公告)日：1977-08-31

申请号：ZA7605434

申请日：1976-09-10

Applicant: HOECHST AG

Inventor： VON POELNITZ W ,  DITTMAR W ,  RODENBERG H ,  FUTTERER E ,  BOHN H

IPC: A61K8/00 ,  A61K8/98 ,  A61K38/22 ,  A61Q5/00 ,  A61Q7/00 ,  A61K

CPC classification number: A61Q7/00 ,  A61K8/982 ,  A61K38/22

公开(公告)号：NO763124L

公开(公告)日：1977-03-15

申请号：NO763124

申请日：1976-09-10

Applicant: HOECHST AG

Inventor： POELNITZ W FREIHERR VON ,  DITTMAR W ,  FUTTERER E ,  BOHN H ,  RODENBERG H

IPC: A61K8/00 ,  A61K8/98 ,  A61K38/22 ,  A61Q5/00 ,  A61Q7/00 ,  A61K

公开(公告)号：NO763124A

公开(公告)日：1977-03-15

申请号：NO763124

申请日：1976-09-10

Applicant: HOECHST AG

Inventor： POELNITZ W FREIHERR VON ,  DITTMAR W ,  FUTTERER E ,  BOHN H ,  RODENBERG H

IPC: A61K8/00 ,  A61K8/98 ,  A61K38/22 ,  A61Q5/00 ,  A61Q7/00 ,  A61K

CPC classification number: A61Q7/00 ,  A61K8/982 ,  A61K38/22

公开(公告)号：NO132197B

公开(公告)日：1975-06-23

申请号：NO348569

申请日：1969-09-01

Applicant: HOECHST AG

Inventor： LOHAUS G ,  DITTMAR W

IPC: C07D217/24 ,  C07D213/89 ,  C07D221/04 ,  C07D405/04