公开(公告)号：AU5103796A

公开(公告)日：1996-10-16

申请号：AU5103796

申请日：1996-03-08

Applicant: HOECHST AG

Inventor： PEYMAN ANUSCHIRWAN ,  RUPPERT DIETER ,  RIESS GUNTHER

IPC: C07D213/89 ,  A61K31/44

公开(公告)号：NO177351C

公开(公告)日：1995-08-30

申请号：NO894663

申请日：1989-11-23

Applicant: HOECHST AG

Inventor： HENNING RAINER ,  URBACH HANSJORG ,  RUPPERT DIETER ,  SCHOLKENS BERNWARD

IPC: C07D213/40 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/4433 ,  A61K38/00 ,  A61K38/55 ,  A61P9/12 ,  C07D233/64 ,  C07D401/12 ,  C07D409/12 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81 ,  C07K5/08 ,  C07K5/087

Abstract: The invention relates to compounds of the formula I in which A is a radical of the formula II in which E is a CH2 group or a radical NR , G is a radical from the group comprising S, SO, SO2, O, CO, CS or a direct bond, B is an amino acid, D is a heterocycle, and R , R , R , R , R , R and R are defined in the description, and the salts thereof. The invention also relates to a process for preparing the compounds of the formula I and to the use thereof as medicines.

公开(公告)号：NO177351B

公开(公告)日：1995-05-22

申请号：NO894663

申请日：1989-11-23

Applicant: HOECHST AG

Inventor： HENNING RAINER ,  URBACH HANSJORG ,  RUPPERT DIETER ,  SCHOLKENS BERNWARD

IPC: C07D213/40 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/4433 ,  A61K38/00 ,  A61K38/55 ,  A61P9/12 ,  C07D233/64 ,  C07D401/12 ,  C07D409/12 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81 ,  C07K5/08 ,  C07K5/087

Abstract: The invention relates to compounds of the formula I in which A is a radical of the formula II in which E is a CH2 group or a radical NR , G is a radical from the group comprising S, SO, SO2, O, CO, CS or a direct bond, B is an amino acid, D is a heterocycle, and R , R , R , R , R , R and R are defined in the description, and the salts thereof. The invention also relates to a process for preparing the compounds of the formula I and to the use thereof as medicines.

公开(公告)号：NO177143B

公开(公告)日：1995-04-18

申请号：NO903952

申请日：1990-09-11

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  HENNING RAINER ,  LINZ WOLFGANG ,  NICKEL WOLF-ULRICH ,  RUPPERT DIETER ,  URBACH HANSJORG

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61P9/12 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07K5/02

Abstract: The invention relates to renin-inhibiting amino-acid derivatives of the formula in which R is a radical of a substituted nitrogen-containing heterocycle such as piperidine, X is CO, CS, SO2 or SO, Y is CH2, O or S, B is the residue of an amino acid of the formula H-B-OH, and R , R and R are as defined in the description, process for their preparation, agents containing them and their use.

公开(公告)号：FI93645B

公开(公告)日：1995-01-31

申请号：FI895568

申请日：1989-11-22

Applicant: HOECHST AG

Inventor： HENNING RAINER ,  URBACH HANSJOERG ,  RUPPERT DIETER ,  SCHOELKENS BERNWARD

IPC: C07D213/40 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/4433 ,  A61K38/00 ,  A61K38/55 ,  A61P9/12 ,  C07D233/64 ,  C07D401/12 ,  C07D409/12 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81 ,  C07D213/24 ,  C07D263/10 ,  C07D409/14

Abstract: The invention relates to compounds of the formula I in which A is a radical of the formula II in which E is a CH2 group or a radical NR , G is a radical from the group comprising S, SO, SO2, O, CO, CS or a direct bond, B is an amino acid, D is a heterocycle, and R , R , R , R , R , R and R are defined in the description, and the salts thereof. The invention also relates to a process for preparing the compounds of the formula I and to the use thereof as medicines.

公开(公告)号：FI89498B

公开(公告)日：1993-06-30

申请号：FI873295

申请日：1987-07-28

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  KLEEMANN HEINZ-WERNER ,  RUPPERT DIETER ,  SCHOELKENS BERNWARD

IPC: A61K31/415 ,  A61K38/00 ,  C07D233/54 ,  C07D233/64 ,  C07K1/00 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065

Abstract: The invention relates to compounds of the formula in which R1 is absent or denotes hydrogen, alkyl or acyl, A denotes an acyl radical or an amino acid residue, B denotes an amino acid residue, and R2, R3 and R4 are as defined in the specification, and to their salts, to a process for their preparation, to pharmaceutical products containing them, and to their use as medicaments, and intermediates for the preparation of these compounds.

公开(公告)号：ZA924521B

公开(公告)日：1993-02-24

申请号：ZA924521

申请日：1992-06-19

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  HOLGER HEITSCH ,  RUBACH HANSJOERG ,  HANSJOERG RUBACH ,  LINZ WOLFGANG ,  WOLFGANG LINZ ,  HENNING RAINER ,  RAINER HENNING ,  RUPPERT DIETER ,  DIETER RUPPERT

IPC: A61K31/495 ,  A61P9/12 ,  A61P43/00 ,  C07D241/10 ,  C07D249/08 ,  C07D401/04 ,  C07D487/04 ,  C07D519/00 ,  C07D ,  A61C

Abstract: Heterocyclic compounds of the formula (I) in which the radicals have the following meanings: R is, for example, propyl or isobutyl, R is, for example, phenyl or pyridyl, R is, for example, hydrogen, R is, for example, cyclohexylmethyl, R is, for example, hydrogen or hydroxyl, R is, for example, a radical of the formula (II> (CH2)5-CHR -Z (II> where R is, for example, hydrogen, Z represents a 5- to 7-membered heterocyclic ring and s denotes 0, 1, 2, 3 or 4; are potent renin-inhibiting compounds.

公开(公告)号：ZA9204521B

公开(公告)日：1993-02-24

申请号：ZA9204521

申请日：1992-06-19

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  HOLGER HEITSCH ,  RUBACH HANSJOERG ,  HANSJOERG RUBACH ,  LINZ WOLFGANG ,  WOLFGANG LINZ ,  HENNING RAINER ,  RAINER HENNING ,  RUPPERT DIETER ,  DIETER RUPPERT

IPC: A61K31/495 ,  A61P9/12 ,  A61P43/00 ,  C07D241/10 ,  C07D249/08 ,  C07D401/04 ,  C07D487/04 ,  C07D519/00 ,  C07D ,  A61C

CPC classification number: C07D487/04

公开(公告)号：NO922428L

公开(公告)日：1992-12-22

申请号：NO922428

申请日：1992-06-19

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  HENNING RAINER ,  URBACH HANSJOERG ,  RUPPERT DIETER ,  LINZ WOLFGANG

IPC: A61K31/495 ,  A61P9/12 ,  A61P43/00 ,  C07D241/10 ,  C07D249/08 ,  C07D401/04 ,  C07D487/04 ,  C07D519/00

Abstract: Heterocyclic compounds of the formula (I) in which the radicals have the following meanings: R is, for example, propyl or isobutyl, R is, for example, phenyl or pyridyl, R is, for example, hydrogen, R is, for example, cyclohexylmethyl, R is, for example, hydrogen or hydroxyl, R is, for example, a radical of the formula (II> (CH2)5-CHR -Z (II> where R is, for example, hydrogen, Z represents a 5- to 7-membered heterocyclic ring and s denotes 0, 1, 2, 3 or 4; are potent renin-inhibiting compounds.

公开(公告)号：AU630386B2

公开(公告)日：1992-10-29

申请号：AU4600589

申请日：1989-12-08

Applicant: HOECHST AG

Inventor： RUGER WOLFGANG ,  URBACH HANSJORG ,  RUPPERT DIETER ,  SCHOLKENS BERNWARD

IPC: C12N9/99 ,  A61K38/00 ,  A61K38/55 ,  A61P9/00 ,  A61P9/12 ,  A61P31/12 ,  C07K1/02 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81 ,  A61K37/02 ,  A61K37/64

Abstract: The present invention relates to compounds of the formula I in which A and B are, independently of one another, an amino acid, X either can be absent or is -O-, -S-, -CF2-, -CO- or -CHR , p and q are, independently of one another, 0, 1, 2, 3 or 4, and R to R are defined in the description, and the salts thereof. The invention also relates to a process for preparing the compounds of the formula I and to their use as medicines.