公开(公告)号：KR790001860B1

公开(公告)日：1979-12-26

申请号：KR740003673

申请日：1974-09-23

Applicant: HOECHST AG

Inventor： LEROH U ,  BARTMANN W ,  MILOS BABEJ

IPC: C07C51/00

Abstract: Prostanoic acid [I; u= (CH2)m, m = 0-5, - R3CCR4-, (R3 = / ≠ R4 = H, C1-C5 alkyl, but when X is (CH2)1-3, R3,R4 ≠ H at the same time), V= single bond, O, W = R5CR6 (R5 = / ≠ R6 = 0), C1-C5 alkyl) and its acid salts useful as anticonvulsive, were prepd. by retro-Dieckmann condensation of II to give III, followed by alkali safonification of III, decarboxylating, and then isolating ethers from III.

公开(公告)号：KR790001361B1

公开(公告)日：1979-09-28

申请号：KR740002787

申请日：1974-06-15

Applicant: HOECHST AG

Inventor： BECK GERHARD ,  MILOS BABEJ ,  LERCH ULRICH ,  BARTMANN WILHELM

Abstract: Title compds. (I; R1,R2 = O; R3,R4 = C1-5 alkyl ; R5 = tetrahydropyranyl, H ; U = (CH2)0-5, cis- or trans-alkyl = c-alkyl; V = simple bond, O, furan, benzyl ; W = alkyl-C-alkyl; X = (CH2)0-4), similar in structure to natural prostaglandine, having strong antiprostaglandine activity were prepd. by reaction of II and in aprotic solvent. Thus, 3.66g (5RS,3'RS)-2-oxo-5 3'-(2"-tetrahydropyranyloxy) -trans-1'-octenyl -cyclopentane-carboxylic ester in C6H5CH3 were stirred with 1.35g potassium-t-butylate followed by reaction with 4g 7-iodo-heptanophosphoric ethyl ester to give I.

公开(公告)号：KR790001979B1

公开(公告)日：1979-12-30

申请号：KR790002417

申请日：1979-09-20

Applicant: HOECHST AG

Inventor： BARTMANN W ,  MILOS BABEJ ,  BECK G

IPC: C07C177/00

Abstract: Prostaglandin analogues and their intermediates (I; R1 and R2 are different, H or hydroxyl group, R3 = C1-5 alkyl, R4 = C1-5 alkyl, R5 = tetrahydropyranyl of H,U = (CH2)m, m = 0-5, R6 and R7 are same or not, H or C1-5 alkyl group, V = C1-5 alkyl, W =C1-5 alkyl, X = (CH2) m, m = 0-5). The compds, had strong antiprostaglandin activity. Thus, compd. II was reacted with hydrated metal complex to give I.