公开(公告)号：AU8982591A

公开(公告)日：1992-06-25

申请号：AU8982591

申请日：1991-12-18

Applicant: HOECHST AG

Inventor： MULLNER STEFAN ,  KONIG WOLFGANG ,  MULLER GUNTER

IPC: A61K38/00 ,  A61K38/06 ,  A61K38/08 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P43/00 ,  C07K1/113 ,  C07K5/08 ,  C07K5/087 ,  C07K5/10 ,  C07K7/00 ,  C07K7/06 ,  C07K14/62 ,  C07K7/40 ,  A61K37/02

Abstract: Short peptides of the formula I X-Y-A-B-C-Cys-D-E (I> in which A and B are an amino acid or a covalent bond, C and D are an amino acid or a substituted amino acid, E is a modified or unmodified amino acid or a covalent bond, X is a radical or hydrogen and Y is leucine or a covalent bond, or dimers of the peptides of the formula I with cystine as dimerisation component, the stereoisomeric forms thereof where appropriate or their physiologically tolerated salts, the preparation thereof, and their use for the treatment of diabetes mellitus are described.

公开(公告)号：CZ90999A3

公开(公告)日：1999-06-16

申请号：CZ90999

申请日：1997-09-15

Applicant: HOECHST AG

Inventor： ERTL JOHANN ,  PREIBISCH GERALD ,  MULLER GUNTER

IPC: C12N15/09 ,  A61K38/00 ,  A61K38/17 ,  A61K38/22 ,  A61K45/00 ,  A61P3/10 ,  A61P5/50 ,  C07K14/575 ,  C07K16/26 ,  C07K19/00 ,  C12P21/02

Abstract: The invention relates to pharmaceutical agents containing leptin antagonists for treating Type II diabetes. One leptin antagonist is based on a murine leptin fragment and comprises amino acids 116 to 167 or 116 to 166. Methods of treating Type II diabetes are also disclosed.

公开(公告)号：CZ9703775A3

公开(公告)日：1998-06-17

申请号：CZ377597

申请日：1997-11-27

Applicant: HOECHST AG

Inventor： FRICK WENDELIN ,  MULLER GUNTER

IPC: C07H15/207 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/715 ,  A61K31/716 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P5/00 ,  A61P5/48 ,  C07H3/04 ,  C07H3/06 ,  C07H11/04 ,  C07H15/203 ,  C08B37/00

CPC classification number: C07H3/06 ,  C07H3/04 ,  Y10S514/866

公开(公告)号：AU643349B2

公开(公告)日：1993-11-11

申请号：AU8982591

申请日：1991-12-18

Applicant: HOECHST AG

Inventor： MULLNER STEFAN ,  KONIG WOLFGANG ,  MULLER GUNTER

IPC: A61K38/00 ,  A61K38/06 ,  A61K38/08 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P43/00 ,  C07K1/113 ,  C07K5/08 ,  C07K5/087 ,  C07K5/10 ,  C07K7/00 ,  C07K7/06 ,  C07K14/62 ,  C07K7/40 ,  A61K37/02

Abstract: Short peptides of the formula I X-Y-A-B-C-Cys-D-E (I> in which A and B are an amino acid or a covalent bond, C and D are an amino acid or a substituted amino acid, E is a modified or unmodified amino acid or a covalent bond, X is a radical or hydrogen and Y is leucine or a covalent bond, or dimers of the peptides of the formula I with cystine as dimerisation component, the stereoisomeric forms thereof where appropriate or their physiologically tolerated salts, the preparation thereof, and their use for the treatment of diabetes mellitus are described.

公开(公告)号：PT99850A

公开(公告)日：1992-11-30

申请号：PT9985091

申请日：1991-12-18

Applicant: HOECHST AG

Inventor： MULLNER STEFAN ,  KONIG WOLFGANG ,  MULLER GUNTER

IPC: A61K38/00 ,  A61K38/06 ,  A61K38/08 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P43/00 ,  C07K1/113 ,  C07K5/08 ,  C07K5/087 ,  C07K5/10 ,  C07K7/00 ,  C07K7/06 ,  C07K14/62 ,  C07K7/40 ,  A61K37/02

Abstract: Short peptides of the formula I X-Y-A-B-C-Cys-D-E (I> in which A and B are an amino acid or a covalent bond, C and D are an amino acid or a substituted amino acid, E is a modified or unmodified amino acid or a covalent bond, X is a radical or hydrogen and Y is leucine or a covalent bond, or dimers of the peptides of the formula I with cystine as dimerisation component, the stereoisomeric forms thereof where appropriate or their physiologically tolerated salts, the preparation thereof, and their use for the treatment of diabetes mellitus are described.

公开(公告)号：FI915933A

公开(公告)日：1992-06-20

申请号：FI915933

申请日：1991-12-17

Applicant: HOECHST AG

Inventor： MULLNER STEFAN ,  KOENIG WOLFGANG ,  MULLER GUNTER

IPC: A61K38/00 ,  A61K38/06 ,  A61K38/08 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P43/00 ,  C07K1/113 ,  C07K5/08 ,  C07K5/087 ,  C07K5/10 ,  C07K7/00 ,  C07K7/06 ,  C07K14/62 ,  C07K

Abstract: Short peptides of the formula I X-Y-A-B-C-Cys-D-E (I> in which A and B are an amino acid or a covalent bond, C and D are an amino acid or a substituted amino acid, E is a modified or unmodified amino acid or a covalent bond, X is a radical or hydrogen and Y is leucine or a covalent bond, or dimers of the peptides of the formula I with cystine as dimerisation component, the stereoisomeric forms thereof where appropriate or their physiologically tolerated salts, the preparation thereof, and their use for the treatment of diabetes mellitus are described.

公开(公告)号：CA2222103C

公开(公告)日：2007-08-28

申请号：CA2222103

申请日：1997-11-25

Applicant: HOECHST AG

Inventor： FRICK WENDELIN ,  MULLER GUNTER

IPC: C07H11/00 ,  C07H15/207 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/715 ,  A61K31/716 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P5/00 ,  A61P5/48 ,  A61P5/50 ,  C07H3/04 ,  C07H3/06 ,  C07H11/04 ,  C07H13/00 ,  C07H15/203 ,  C08B37/00

Abstract: Inositolglycans having insulin-like action Compounds of the formula I A-Z-R (I) are described, where A is the radical H - P(O)(OH) -, H - P(S)(OH) -, HO-- P(S)(OH) -, HS-P(S)(OH) -, (C1-C4) - alkyl - P(O)(OH) -, (C1-C4) - alkyl - P(S)(OH)-, S(O)2(OR1) -, S(O)(OR1)-, NH2 - C(O) -, R1R2N -, R1R2N - C(O) - NH -, R1O - SO2 - NH -, (C1-C4) - alkyl - SO2 -, (C1-C4) - alkyl - S(O) - or R1 - S -, Z is 2 to 6 substituted or unsubstituted sugar radicals and R is substituted or unsubstituted inositol. The compounds of the formula I are suitable for the treatment of diabetes mellitus or noninsulin-dependent diabetes.

公开(公告)号：CZ294886B6

公开(公告)日：2005-04-13

申请号：CZ377597

申请日：1997-11-27

Applicant: HOECHST AG

Inventor： FRICK WENDELIN ,  MULLER GUNTER

IPC: C07H15/207 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/715 ,  A61K31/716 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P5/00 ,  A61P5/48 ,  C07H3/04 ,  C07H3/06 ,  C07H11/04 ,  C07H15/203 ,  C08B37/00

Abstract: In the present invention, there is disclosed inositol glycans exhibiting insulin like activity of the general formula A - Z - R, in which A represents the groups HP(O)(OH)-, S(O)i2(ORe1)-, NHi2C(O)-, Z denotes 2 to 6 sugar radicals and R represents inositol and phosphates thereof. The invented inositol glycans are suitable for the treatment of diabetes mellitus or noninsulin-dependent diabetes. There is also described process of their preparation, their use as well as pharmaceutical compositions in which the above-indicated substances are comprised.

公开(公告)号：CA2058020C

公开(公告)日：2003-10-28

申请号：CA2058020

申请日：1991-12-18

Applicant: HOECHST AG

Inventor： MULLNER STEFAN ,  KONIG WOLFGANG ,  MULLER GUNTER

IPC: A61K38/00 ,  A61K38/06 ,  A61K38/08 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P43/00 ,  C07K1/113 ,  C07K5/08 ,  C07K5/087 ,  C07K5/10 ,  C07K7/00 ,  C07K7/06 ,  C07K14/62 ,  A61K38/04 ,  C07K5/04

Abstract: Short peptides with insulin activity Short peptides of the formula I X-Y-A-B-C-Cys-D-E (I) where A and B are an amino acid or a covalent bond, C and D are an amino acid or a substituted amino acid, E is a modified or unmodified amino acid or a covalent bond, X is a radical or hydrogen and Y is leucine or a covalent bond, or dimers of the peptides of the formula I with cystine as dimerization component, the stereoisomeric forms thereof where appropriate, or the physiologically tolerated salts thereof, the preparation thereof and the use thereof for the treatment of diabetes mellitus are described.

公开(公告)号：AU4538297A

公开(公告)日：1998-06-04

申请号：AU4538297

申请日：1997-11-26

Applicant: HOECHST AG

Inventor： FRICK WENDELIN ,  MULLER GUNTER

IPC: C07H15/207 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/715 ,  A61K31/716 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P5/00 ,  A61P5/48 ,  C07H3/04 ,  C07H3/06 ,  C07H11/04 ,  C07H15/203 ,  C08B37/00 ,  C07H13/00

Abstract: Inositol glycan derivatives of formula (I), their salts and stereoisomeric forms, are new: A-Z-R (I) A = HP(=O)(OH), HP(=S)(OH), HOP(=S)(OH), HSP(=S)(OH), (1-4C alkyl)P(=O)(OH), (1-4C alkyl)P(=S)(OH), SO2ORl, S(=O)OR1, NH2CO, NR1R2, R1R2NCONH, R1OSO2NH, (1-4C alkyl)SO2, (1-4C alkyl)S(=O) or R1S; R1, R2 = H or 1-4C alkyl; Z = 2-6 sugar residues (optionally substituted by up to 6 Me, sugar residue, di-sugar residue, SO2OH, CONR1R2, CO(1-4C alkyl), P(=O)(H)OH, P(=O)(OH)2, P(=S)(H)OH, P(=S)(OH)2, P(=S)(SH)(OH), P(=O)(OH)OCH2CH2NR1R2), or the glycosidic bridge between the 2-6 sugar residues may be 1-6 fold replaced by CH2 or S; R = inositol, inositol phosphate, inositol thiophosphate, inositol cyclo-phosphate, inositol cyclo-thiophosphate (optionally substituted by 1-2 phosphate or thiophosphate, or single substitution by cyclo-phosphate or cyclo-thiophosphate), or inositol (where two neighbouring OH groups are replaced by CH2SO2NH).