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    PROCESS FOR PREPARING NETOXIC SALTS OF 6-METHYL-3,4- DIHYDRO-1,2,3-OXATHIAZIN-4-ON,2,2-DIOXIDE
    4.
    发明专利
    PROCESS FOR PREPARING NETOXIC SALTS OF 6-METHYL-3,4- DIHYDRO-1,2,3-OXATHIAZIN-4-ON,2,2-DIOXIDE 未知

    公开(公告)号：CS262439B2

    公开(公告)日：1989-03-14

    申请号：CS632386

    申请日：1986-09-01

    Applicant: HOECHST AG

    Inventor： REUSCHLING DIETER DR ,  LINKIES ADOLF DR ,  REIMANN WALTER DR ,  SCHWEIKERT OTTO E DR ,  MACK KARL E DR ,  EBERTZ WOLFGANG DR

    IPC: A23L27/20 ,  A23L27/30 ,  C07D291/06

    Abstract: The non-toxic salts of 6-methyl-3,4-dihydro-1,2,3-oxothiazin-4-one 2,2-dioxide are prepared by cyclizing acetoacetamide-N-sulfonic acid or its salts with an at least approximately equimolar amount of SO3 in the presence of a water-immiscible, inert organic solvent and, if appropriate, also an inert inorganic solvent, hydrolyzing the 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-one 2,2-dioxide obtained in the form of the SO3-adduct after the cyclization reaction, in the event that the amount of SO3 employed is more than equimolar, purifying the organic phase (which has separated out) by extraction with a small volume of water or dilute aqueous sulfuric acid, preferably only with water, and isolating, by neutralization with bases, the non-toxic salts of the 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-one 2,2-dioxide from the organic phase thus purified. The said salts are obtained in this process in an extremely pure form; they are valuable synthetic sweetening agents. The potassium salt is known as acesulfam (K).

    6.
    发明专利
    未知

    公开(公告)号：DE3779352D1

    公开(公告)日：1992-07-02

    申请号：DE3779352

    申请日：1987-04-14

    Applicant: HOECHST AG

    Inventor： LOHAUS GERHARD DR ,  DITTMAR WALTER DR ,  HAENEL HEINZ DR ,  RAETHER WOLFGANG DR ,  REUSCHLING DIETER DR ,  GROEBEL BENGT-THOMAS DR

    IPC: A61K31/44 ,  C07D213/89 ,  C07D309/38

    Abstract: (A) 1-Hydroxy-2-pyridones of formula (I) are new: R1-R3 = H or 1-4C alkyl; X = O or S; Y = H or up to 2 halogen atoms, i.e. Cl and/or Br; Z = a direct bond, O, S, C(R)2, or 2-10C alkylene or alkenylenemm (opt. substd. by 1-4C alkyl) in which one or more C atoms may be replaced by O and/or S, provided that these are sepd. by at least 2C atoms. R = H or 1-4C alkyl; Ar = mono- or bicyclic aryl opt. substd. by up to 3 of F, Cl, Br, OMe, 1-4C alkyl, CF3 and OCF3. (B) Intermediates of formula (IV) are also new. Specifically R1 = R3 = A; R2 = Me; X = O; Z = a bond, O or an O-contg. gp.; Ar = opt. substd. phenyl , biphenyl, phenylalkylphenyl or phenoxyphenyl.

    9.
    发明专利
    未知

    公开(公告)号：DE3410440A1

    公开(公告)日：1985-09-26

    申请号：DE3410440

    申请日：1984-03-22

    Applicant: HOECHST AG

    Inventor： CLAUSS KARL DR ,  LINKIES ADOLF DR ,  REUSCHLING DIETER DR

    IPC: A23L27/30 ,  C07D291/06 ,  A23L1/236

    Abstract: 6-Methyl-3,4-dihydro-1,2,3-oxathiazin-4-one 2,2-dioxide is prepared by reaction of acetoacetamide with at least approximately twice the molar amount of SO3 per mole of acetoacetamide, if appropriate in an inert inorganic or organic solvent. Relevant salts can be obtained, using bases, from the product which results in the form of the acid. The non-toxic salts, in particular the potassium salt, are valuable synthetic sweeteners.

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