公开(公告)号：ES2101925T3

公开(公告)日：1997-07-16

申请号：ES93118284

申请日：1993-11-11

Applicant: HOECHST AG

Inventor： SCHACH THOMAS DR ,  PAPENFUHS THEODOR DR

IPC: B01J23/44 ,  C07B39/00 ,  C07B61/00 ,  C07C17/00 ,  C07C17/23 ,  C07C25/13 ,  C07D213/61

Abstract: 1,3-Difluorobenzene is prepared by catalytic elimination of halogen from a 1,3-difluorohalobenzene by reacting a 1,3-difluorohalobenzene of the formula (1) in which R to R denote H, Cl or Br and at least one of the radicals R to R stands for Cl or Br, in the presence of a palladium catalyst and of an amine, if appropriate in the presence of water or of an organic solvent which is inert to the reactants and the reaction conditions, with hydrogen under pressure and at temperatures from about 70@ to about 140@C.

公开(公告)号：DE59203617D1

公开(公告)日：1995-10-19

申请号：DE59203617

申请日：1992-02-19

Applicant: HOECHST AG

Inventor： SCHACH THOMAS DR ,  PAPENFUHS THEODOR DR

IPC: C07C253/00 ,  C07C253/14 ,  C07C255/50

Abstract: Process for the preparation of 2,4-dichloro-5-fluorobenzonitrile, by reacting 5-bromo-2,4-dichlorofluorobenzene with about 10 to about 300 mol % of copper(I) cyanide in the presence of about 10 to about 2,000 mol % of a polar aprotic solvent at temperatures from about 100 DEG to about 250 DEG C. to give 2,4-dichloro-5-fluorobenzonitrile.

公开(公告)号：DE4416329A1

公开(公告)日：1995-11-16

申请号：DE4416329

申请日：1994-05-09

Applicant: HOECHST AG

Inventor： PFIRMANN RALF DR ,  SCHACH THOMAS DR

IPC: C07C17/093 ,  C07C25/13 ,  C07C201/08 ,  C07C205/12 ,  C07C209/36 ,  C07C211/52 ,  C07C253/00 ,  C07C255/50

Abstract: The prepn. of cpds. of formula (I) is claimed. R = NO2, NH2, CN, Br or Cl. The prepn. comprises (a) reaction of 2,3,4-trifluorochlorobenzene (III) with a nitrating agent at -10 to 50 degrees C, opt. in the presence of a water-insoluble solvent; (b) redn. of 2-chloro-3,4,5-trifluoronitrobenzene (Ia) or a mixt. contg. (Ia) and 5-chloro-2,3,4-trifluoronitrobenzene (IIa), in the presence of an organic solvent; and (c) isolation of 2-chloro-3,4,5-trifluoroaniline (Ib) or a mixt. of (Ib) and 5-chloro-2,3,4-trifluoroaniline (IIb), opt. diazotisation, and exchange of the diazo gp. for Cl, Br or CN. 2-Chloro-3,4,5-trifluorobenzene cpds. (I') of formula (I; R = NO2, NH2, CN or Cl) are new. Also claimed is the use of (I') in the prodn. of 2-chloro-3,4,5-trifluorobenzoic acid (IV) and antibacterial agents (V).

公开(公告)号：DE4034109A1

公开(公告)日：1992-04-30

申请号：DE4034109

申请日：1990-10-26

Applicant: HOECHST AG

Inventor： SCHACH THOMAS DR ,  PAPENFUHS THEODOR DR ,  HACKENBRUCH JOACHIM DR

IPC: B01J23/44 ,  C07B37/04 ,  C07B61/00 ,  C07C1/26 ,  C07C15/14 ,  C07C15/24 ,  C07C17/26 ,  C07C25/18 ,  C07C25/22 ,  C07C41/30 ,  C07C43/20 ,  C07C43/205 ,  C07C315/04 ,  C07C317/14

Abstract: Process for the production of diaryls of formula (1): R m - Ar - Ar - R m in which: Ar is a phenylene or naphthylene group; R1 is a hydrogen, fluorine or chlorine atom or an unbranched or branched alkyl (C1-C6)-alkyl(C1C6)-O-, alkyl (C1C6)-CO- or alkyl(C1C6)-SO2 group; and m is the number of the still unsubstituted ( alpha )-positions in the Ar group, by dehalogenating and dimerising a compound of formula (2): R m - Ar - X, in which Ar, R and m have the above significances and X is a chlorine or bromine atom, in the presence of a palladium catalyst on a substrate, a reducing agent, a halogen hydrogen acceptor, a polyether or polyether mixture and water at temperatures of 50 to 120 DEG C.

公开(公告)号：DE19544870A1

公开(公告)日：1997-06-05

申请号：DE19544870

申请日：1995-12-01

Applicant: HOECHST AG

Inventor： NEUBER MARITA DR ,  SCHACH THOMAS DR ,  PAPENFUHS THEODOR DR ,  PFIRMANN RALF DR ,  ROSCHER GUENTER DR

IPC: B01J27/122 ,  C07B61/00 ,  C07C17/093 ,  C07C17/35 ,  C07C25/13

公开(公告)号：DE59305733D1

公开(公告)日：1997-04-17

申请号：DE59305733

申请日：1993-11-11

Applicant: HOECHST AG

Inventor： SCHACH THOMAS DR ,  PAPENFUHS THEODOR DR

IPC: B01J23/44 ,  C07B39/00 ,  C07B61/00 ,  C07C17/00 ,  C07C17/23 ,  C07C25/13 ,  C07D213/61

Abstract: 1,3-Difluorobenzene is prepared by catalytic elimination of halogen from a 1,3-difluorohalobenzene by reacting a 1,3-difluorohalobenzene of the formula (1) in which R to R denote H, Cl or Br and at least one of the radicals R to R stands for Cl or Br, in the presence of a palladium catalyst and of an amine, if appropriate in the presence of water or of an organic solvent which is inert to the reactants and the reaction conditions, with hydrogen under pressure and at temperatures from about 70@ to about 140@C.

公开(公告)号：DE4444904A1

公开(公告)日：1996-06-27

申请号：DE4444904

申请日：1994-12-16

Applicant: HOECHST AG

Inventor： SCHACH THOMAS DR ,  PAPENFUHS THEODOR DR

IPC: C07C17/23 ,  C07D213/61 ,  C07C25/13 ,  C07B37/04

Abstract: Prodn. of fluoro-aromatic cpds. of formula FnArR1R2R3 (I) comprises reacting a (chloro or bromo)-fluoro-aromatic cpd. of formula XmFnArR1R2R3 with hydrogen in the presence of a palladium catalyst and a water-insoluble amine which forms a water-insoluble hydrohalide and opt. in an inert solvent. Ar = phenyl, naphthyl or pyridyl; R1-R3 = H, halo, 1-4C alkyl, phenyl, NR2, OR, CN, CHO or COR; R = H or 1-6C alkyl; X = Cl or Br; m, n = 1-5;

公开(公告)号：DE59300243D1

公开(公告)日：1995-07-13

申请号：DE59300243

申请日：1993-03-17

Applicant: HOECHST AG

Inventor： SCHACH THOMAS DR ,  PAPENFUHS THEODOR DR

IPC: B01J23/44 ,  C07B61/00 ,  C07C17/00 ,  C07C17/093 ,  C07C25/13 ,  C07C201/08 ,  C07C201/12 ,  C07C205/12 ,  C07C209/36 ,  C07C211/52

Abstract: In a process for the preparation of 3,5-difluoroaniline, …… (1) 2,4,5-trichloronitrobenzene is reacted with an alkali metal fluoride in the presence or absence of a polar aprotic solvent at temperatures from approximately 100 DEG C to approximately 250 DEG C, the precipitated salts are filtered off, and the crude solution is subjected to fractional distillation, … (2) the resulting 5-chloro-2,4-difluoronitrobenzene is subjected to denitrating chlorination with anhydrous chlorine gas in the absence of a Lewis acid or of another chlorination catalyst at temperatures from approximately 80 to approximately 250 DEG C, to give 1,3-dichloro-4,6-difluorobenzene, … (3) this compound is nitrated in oleum using mixed acid (sulphuric acid/nitric acid) at temperatures from approximately 15 to approximately 80 DEG C to give 2,6-dichloro-3,5-difluoronitrobenzene, and … (4) this compound is reduced with hydrogen in the presence of palladium as catalyst and in the presence of an inorganic or organic base at temperatures from approximately 40 to approximately 250 DEG C. …

公开(公告)号：DE4324367A1

公开(公告)日：1995-01-26

申请号：DE4324367

申请日：1993-07-21

Applicant: HOECHST AG

Inventor： SCHACH THOMAS DR ,  PAPENFUHS THEODOR DR

IPC: B01J31/02 ,  C07B61/00 ,  C07C201/12 ,  C07C205/12

Abstract: Fluoronitrobenzenes are prepared advantageously by a chlorine/fluorine exchange reaction in which a chlorine atom and a fluorine atom from the corresponding chloronitrobenzenes and an alkali metal fluoride are exchanged, the process being carried out by catalysing the reaction with a quaternary ammonium compound containing at least one alkoxypolyoxyalkyl radical.

公开(公告)号：DE19702282C2

公开(公告)日：1998-11-19

申请号：DE19702282

申请日：1997-01-23

Applicant: HOECHST AG

Inventor： PASENOK SERGEJ DR ,  APPEL WOLFGANG DR ,  PFIRMANN RALF DR ,  WESSEL THOMAS DR ,  SCHACH THOMAS DR ,  SCHUBERT HANS DR

IPC: B01J31/02 ,  C07B39/00 ,  C07B61/00 ,  C07C17/20 ,  C07C25/02 ,  C07C45/63 ,  C07C47/55 ,  C07C201/12 ,  C07C205/12 ,  C07C205/07 ,  C07C25/13 ,  C07D227/06 ,  C07D247/00 ,  C07D255/02

Abstract: PCT No. PCT/EP90/00332 Sec. 371 Date Jul. 21, 1999 Sec. 102(e) Date Jul. 21, 1999 PCT Filed Jan. 22, 1998 PCT Pub. No. WO98/32532 PCT Pub. Date Jul. 30, 1998Catalyst for halogen-fluorine exchange reactions on aromatics, consisting essentially of a mixture of one or more compounds of the component a) plus at least one compound of the components b), c) and/or d), wherein a) is an amidophosphonium salt of the formula (I) where A1, A2, A3, A4, A5, A6, A7, A8 are, independently of one another, identical or different and are each a straight-chain or branched alkyl or alkenyl having from 1 to 12 carbon atoms, cycloalkyl having from 4 to 8 carbon atoms, an aryl having from 6 to 12 carbon atoms, an aralkyl having from 7 to 12 carbon atoms, or A1 A2, A3A4, A5A6, A7A8 are, independently of one another, identical or different and are in each case connected to one another either directly or via O or N-A9 to form a ring having from 3 to 7 ring atoms, A9 is an alkyl having from 1 to 4 carbon atoms and B(-) is a monovalent acid anion or the equivalent of a polyvalent acid anion, b) a quaternary ammonium salt, c) a quaternary phosphonium salt, and d) a crown ether or a polyether of the formula (IV): R10 -(O-OxH2x)r-OR11 (IV).