公开(公告)号：NZ219606A

公开(公告)日：1989-09-27

申请号：NZ21960687

申请日：1987-03-13

Applicant: HOECHST AG

Inventor： BLUME E ,  SCHAPER W ,  EHRHARDT H ,  RAETHER W ,  DITTMAR W ,  HANEL H ,  SACHSE B

IPC: C07D247/00 ,  A01N43/50 ,  A01N43/653 ,  C07C41/00 ,  C07C43/18 ,  C07C67/00 ,  C07C201/00 ,  C07C213/00 ,  C07C215/42 ,  C07C217/48 ,  C07C217/74 ,  C07C253/00 ,  C07C255/54 ,  C07C313/00 ,  C07C317/12 ,  C07C317/14 ,  C07C317/18 ,  C07C317/20 ,  C07C323/22 ,  C07D233/56 ,  C07D233/60 ,  C07D233/61 ,  C07D249/08 ,  C07D307/38 ,  C07D333/00 ,  C07D401/12 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12 ,  C07D521/00 ,  C07D239/06 ,  C07D231/12 ,  C07D405/08 ,  C07D405/14 ,  C07D417/08 ,  C07D417/14 ,  C07D403/06 ,  C07D403/08 ,  C07D403/14 ,  C07D401/06 ,  C07D401/08 ,  C07D401/14 ,  A61K31/41 ,  A61K31/415

Abstract: Compounds I I where A equals t-butyl or a large number of (substituted) aromatics; Y equals azolyl; or Y equals -X-R1 where X=oxygen or sulfur and R1 equals (cyclo)alkyl or (heterocyclic) aryl; or Y equals where R2 equals (cyclo)alkyl, acetyl or aryl; or Y equals -NR3R4 where R3/R4 is alkyl; or Y equals several nitrogen-containing heterocyclic rings; Z equals OH, alkylcarbonyloxy, hal, alkoxy or benzyloxy; and the salts thereof are effective antimycotics or fungicides. They are obtained by reaction of II II with (CH3)2 III and further reaction of the compound IV obtained from this with a nucleophile YM (M=hydrogen or a metal equivalent). The compounds I (where Z=OH) resulting from this can be acylated or alkylated, or converted into I where Z=hal.