公开(公告)号：CA610010A

公开(公告)日：1960-12-06

申请号：CA610010D

Applicant: HOECHST AG

Inventor： DIERY HELMUT ,  HEYNA JOHANNES ,  SCHMIDT-RUPPIN HEINZ

公开(公告)号：CA728143A

公开(公告)日：1966-02-15

申请号：CA728143D

Applicant: HOECHST AG

Inventor： ROLLY HEINRICH ,  LEDITSCHKE HEINRICH ,  SCHMIDT-RUPPIN HEINZ

公开(公告)号：GB854443A

公开(公告)日：1960-11-16

申请号：GB1794657

申请日：1957-06-05

Applicant: HOECHST AG

Inventor： DIERY HELMUT ,  SCHMIDT-RUPPIN HEINZ ,  HEYNA JOHANNES

IPC: B28C9/00 ,  C07F9/564

Abstract: The invention comprises ethyleneimine derivatives of the formula : in which R is an alkyl, cycloalkyl or aryl group. They may be obtained by reacting an appropriate thiophosphoric monoester dihalide, e.g. chloride or bromide with ethyleneimine in the presence of an acid-binding agent. Specified acid binding agents are tertiary amines, e.g. trimethylamine or triethylamine, anhydrous ammonia, sodium carbonate, potassium carbonate, sodium acetate, and sodium hydroxide. The reaction may be carried out in an aqueous medium or in an organic solvent, e.g. a hydrocarbon, chlorinated hydrocarbon, ketone or ether. Examples are given for the production of products of the above formula in which R is ethyl, butyl, cyclohexyl, isobutyl, n-amyl, and phenyl respectively. The products have the property of checking the growth of malignant tumours.

公开(公告)号：CA585045A

公开(公告)日：1959-10-13

申请号：CA585045D

Applicant: HOECHST AG

Inventor： ROLLY HEINRICH ,  SCHMIDT-RUPPIN HEINZ ,  LEDITSCHKE HEINRICH