公开(公告)号：NZ182329A

公开(公告)日：1978-06-02

申请号：NZ18232976

申请日：1976-10-14

Applicant: HOECHST AG

Inventor： LERCH U ,  SEEGAR K ,  BECK G ,  BARTMANN W

IPC: C07C69/73 ,  A61K31/23 ,  A61K31/34 ,  A61K31/341 ,  A61K31/357 ,  A61K31/38 ,  A61K31/381 ,  A61P43/00 ,  C07C51/00 ,  C07C59/46 ,  C07C59/62 ,  C07C59/82 ,  C07C67/00 ,  C07C253/00 ,  C07C255/46 ,  C07C401/00 ,  C07C405/00 ,  C07D307/54 ,  C07D317/30 ,  C07D319/08 ,  C07D333/24 ,  C07D407/12 ,  C07D409/06 ,  C07D409/14

Abstract: Cyclohexane derivs. (I) and their intermediates are new: In the formula one of R1, R2=H the other=hydroxy or together they form oxo; R3=H, 1-6C opt. branched opt. unsatd. aliphatic or cycloaliphatic radical, 7-9C araliphatic radical, a metallic ion, opt. substd. NH4 or a prim., sec. or tert. amine deriv. R4 is 1-10C opt. branched, opt. unsatd. aliphatic hydrocarbyl or 3-7C cycloaliphatic hydrocarbyl each opt. substd. by (a) 1-7C opt. branched, opt. unsatd. alkoxy or alkylthio, (b) phenoxy opt. substd. by 1 or 2 of 1-3C opt. halo substd. alkyl, halo, phenoxy (opt. substd. by halo) or 1-4C alkoxy, (c) furyloxy, thienyl or benyloxy each opt. mono or independently di-substd. by 1-3C opt. halo substd alkyl, halo or 1-4C alkoxy (d) 1 or 2 F atoms, CF3, or CF2-CF3, (e) 3-7C cycloalkyl (f) phenyl, thienyl or furyl each opt. mono- or independently di-substd. by 1-3C opt. halo substd. alkyl, halo or 1-4C alkoxy. R5 is 1-5C alkyl, 2-5C alkenyl or alkynyl or H; n=2, 3 or 4 and A=trans-CH=CH- or -CH2-CH2-. A typical cpd. is 7-3-(3-hydroxy-(E)-1-actene-1-yl cyclohexane-1-one-2-yl-(Z)-4-heptenoic acid.