公开(公告)号：JPS62297325A

公开(公告)日：1987-12-24

申请号：JP11603987

申请日：1987-05-14

Applicant: HOECHST AG

Inventor： BADER HUBERT ,  RUEPPEL DIETHER ,  WALCH AXEL ,  MAGERSTAEDT MICHAEL

IPC: A61K9/00 ,  A61K9/16 ,  A61K9/20 ,  A61K9/22 ,  A61K47/00 ,  A61K47/34 ,  C08G69/02 ,  C08G69/10 ,  C08G69/44

公开(公告)号：NO307422B1

公开(公告)日：2000-04-03

申请号：NO950889

申请日：1995-03-08

Applicant: HOECHST AG

Inventor： AHLERS MICHAEL ,  WALCH AXEL ,  SEIPKE GERHARD ,  RUSSELL-JONES GREGORY JOHN

IPC: A61K47/34 ,  A61K9/51 ,  A61K47/48 ,  A61P3/00 ,  C08G69/40

Abstract: Nanoparticles contg. an active ingredient (A) and a poly (ketal tartaric acid amide) (B) with at least 95 mole% of repeating units of formula (I) are new: X = NH; R2 = alkyl or cycloalkyl, opt. with 1 or more inert substits.

公开(公告)号：NO301427B1

公开(公告)日：1997-10-27

申请号：NO932634

申请日：1993-07-21

Applicant: HOECHST AG

Inventor： AHLERS MICHAEL ,  GLOMBIK HEINER ,  GRABLEY SUSANNE ,  GRANZER ERNOLD ,  MUELLNER STEFAN ,  WALCH AXEL ,  XU GUAN-YU

IPC: A23L33/00 ,  A61K31/785 ,  A61K47/30 ,  A61P3/06 ,  A61P3/12 ,  C08F8/12 ,  C08F26/00 ,  C08F226/02 ,  C08F26/02 ,  A23L1/058

Abstract: The invention relates to polyvinylamine derivatives containing hydrophilic centres, of the formula I in which R , R , R , X, w, x, y and z are as defined, and to a process for their preparation, and to the use of these compounds as medicaments (drugs, pharmaceuticals), active compound (active ingredient) carriers and as foodstuff auxiliaries. The preparation starts, in particular, from highly pure polyvinylamines containing the recurring unit of the formula Ia whose preparation is likewise described.a

公开(公告)号：NO301018B1

公开(公告)日：1997-09-01

申请号：NO932635

申请日：1993-07-21

Applicant: HOECHST AG

Inventor： AHLERS MICHAEL ,  GLOMBIK HEINER ,  MUELLNER STEFAN ,  WALCH AXEL

IPC: A61P3/06 ,  C08F8/12 ,  A61K31/785 ,  C08F26/00 ,  C08F26/02 ,  C08F226/00

Abstract: The invention relates to crosslinked, nitrogen-containing vinyl copolymers containing units of the formula I and the physiologically acceptable salts thereof, where, in formula I, A1, A2, R, w, x, y and z are as defined, to a process for their preparation, and to the use of the compounds as medicaments (drugs, pharmaceuticals), active compound (active ingredient) carriers and as foodstuff auxiliaries.

公开(公告)号：AU673479B2

公开(公告)日：1996-11-07

申请号：AU1353195

申请日：1995-02-28

Applicant: HOECHST AG

Inventor： AHLERS MICHAEL ,  GLOMBIK HEINER ,  GRABLEY SUSANNE ,  GRANZER ERNOLD ,  MULLNER STEFAN ,  WALCH AXEL ,  XU GUAN-YU

IPC: A23L33/00 ,  A61K31/785 ,  A61K47/30 ,  A61P3/06 ,  A61P3/12 ,  C08F8/12 ,  C08F26/00 ,  C08F226/02 ,  C08F126/02 ,  A23L1/30 ,  A61K31/135

Abstract: The invention relates to polyvinylamine derivatives containing hydrophilic centres, of the formula I in which R , R , R , X, w, x, y and z are as defined, and to a process for their preparation, and to the use of these compounds as medicaments (drugs, pharmaceuticals), active compound (active ingredient) carriers and as foodstuff auxiliaries. The preparation starts, in particular, from highly pure polyvinylamines containing the recurring unit of the formula Ia whose preparation is likewise described.a

公开(公告)号：AU672643B2

公开(公告)日：1996-10-10

申请号：AU5232893

申请日：1993-12-10

Applicant: HOECHST AG

Inventor： STAHL WILHELM ,  AHLERS MICHAEL ,  WALCH AXEL ,  BARTNIK ECKHART ,  KRETZSCHMAR GERHARD ,  GRABLEY SUSANNE ,  SCHLEYERBACH RUDOLF

IPC: A61K31/715 ,  A61K31/765 ,  A61K31/785 ,  A61K31/80 ,  A61K47/48 ,  A61K49/00 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61P43/00 ,  C07H15/04 ,  C07H15/203 ,  C08B37/00 ,  C08G63/00 ,  C08G63/06 ,  C08G64/00 ,  C08G64/42 ,  C08G65/16 ,  C08G67/04 ,  C08G69/00 ,  C08G69/10 ,  C08G73/16 ,  A61K31/70 ,  C08F8/32

Abstract: The invention relates to physiologically compatible and physiologically degradable polymer-based carbohydrate receptor blocker with an HLB of 10 to 20, containing: carbohydrate portion - bifunctional spacer - hydrophilic biodegradable polymer - potentiator, where the carbohydrate portion consists of 1 to 20 naturally occurring, identical or different, monosaccharide units and is coupled via one or more bifunctional spacers, which is a natural or synthetic molecule, to a hydrophilic biodegradable polymer, and the polymer in turn is the carrier of one or more spacers and the hydrophilic biodegradable polymer is additionally linked to the potentiator which is a crosslinker, one or more groups with hydrophobic, hydrophilic or ionic properties or a solubility improver, to a method for the preparation and to its use in vivo for blocking carbohydrate-recognising receptors. The carbohydrate receptor blocker induces no incompatibility reaction in vivo either in its totality or in the form of breakdown products.

公开(公告)号：AU659746B2

公开(公告)日：1995-05-25

申请号：AU4209093

申请日：1993-07-21

Applicant: HOECHST AG

Inventor： AHLERS MICHAEL ,  GLOMBIK HEINER ,  GRABLEY SUSANNE ,  GRANZER ERNOLD ,  MULLNER STEFAN ,  WALCH AXEL ,  XU GUAN-YU

IPC: A23L33/00 ,  A61K31/785 ,  A61K47/30 ,  A61P3/06 ,  A61P3/12 ,  C08F8/12 ,  C08F26/00 ,  C08F226/02 ,  C08F26/02 ,  A23L1/30

Abstract: The invention relates to polyvinylamine derivatives containing hydrophilic centres, of the formula I in which R , R , R , X, w, x, y and z are as defined, and to a process for their preparation, and to the use of these compounds as medicaments (drugs, pharmaceuticals), active compound (active ingredient) carriers and as foodstuff auxiliaries. The preparation starts, in particular, from highly pure polyvinylamines containing the recurring unit of the formula Ia whose preparation is likewise described.a

公开(公告)号：AU1353195A

公开(公告)日：1995-05-25

申请号：AU1353195

申请日：1995-02-28

Applicant: HOECHST AG

Inventor： AHLERS MICHAEL ,  GLOMBIK HEINER ,  GRABLEY SUSANNE ,  GRANZER ERNOLD ,  MULLNER STEFAN ,  WALCH AXEL ,  XU GUAN-YU

IPC: A23L33/00 ,  A61K31/785 ,  A61K47/30 ,  A61P3/06 ,  A61P3/12 ,  C08F8/12 ,  C08F26/00 ,  C08F226/02 ,  C08F126/02 ,  A23L1/30 ,  A61K31/135

Abstract: The invention relates to polyvinylamine derivatives containing hydrophilic centres, of the formula I in which R , R , R , X, w, x, y and z are as defined, and to a process for their preparation, and to the use of these compounds as medicaments (drugs, pharmaceuticals), active compound (active ingredient) carriers and as foodstuff auxiliaries. The preparation starts, in particular, from highly pure polyvinylamines containing the recurring unit of the formula Ia whose preparation is likewise described.a

公开(公告)号：NZ248193A

公开(公告)日：1995-04-27

申请号：NZ24819393

申请日：1993-07-20

Applicant: HOECHST AG

Inventor： AHLERS MICHAEL ,  GLOMBIK HEINER ,  MULLNER STEFAN ,  WALCH AXEL

IPC: A61P3/06 ,  C08F8/12 ,  C08F26/00 ,  C08F26/02 ,  A61K31/785 ,  C08F8/32 ,  C08F16/32 ,  C08J3/24 ,  C08F26/06 ,  A61K47/48 ,  A23L1/307

Abstract: The invention relates to crosslinked, nitrogen-containing vinyl copolymers containing units of the formula I and the physiologically acceptable salts thereof, where, in formula I, A1, A2, R, w, x, y and z are as defined, to a process for their preparation, and to the use of the compounds as medicaments (drugs, pharmaceuticals), active compound (active ingredient) carriers and as foodstuff auxiliaries.

公开(公告)号：FI951053A0

公开(公告)日：1995-03-07

申请号：FI951053

申请日：1995-03-07

Applicant: HOECHST AG

Inventor： AHLERS MICHAEL ,  WALCH AXEL ,  SEIPKE GERHARD ,  RUSSELL-JONES GREGORY

IPC: A61K47/34 ,  A61K9/51 ,  A61K47/48 ,  A61P3/00 ,  A61K ,  C08G

Abstract: Nanoparticles contg. an active ingredient (A) and a poly (ketal tartaric acid amide) (B) with at least 95 mole% of repeating units of formula (I) are new: X = NH; R2 = alkyl or cycloalkyl, opt. with 1 or more inert substits.