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    2.
    发明专利
    未知

    公开(公告)号：FI44620B

    公开(公告)日：1971-08-31

    申请号：FI276865

    申请日：1965-11-18

    Applicant: HOECHST AG

    Inventor： WEYER R ,  STURM K ,  SIEDEL W

    IPC: C07D307/52 ,  C07C143/80

    Abstract: 1,126,672. Sulphamoylanthranilic hydroxylamides. FARBWERKE HOECHST A.G. 6 Dec., 1965 [8 Dec., 1964], No. 51658/65. Heading C2C. Novel compounds of the formula wherein R 1 is a benzyl, furfuryl or thenyl-(2) group, R 2 is a hydrogen or C 1-3 alkyl, R 3 is hydrogen or methoxy and X is Cl or Br are made either by reacting an appropriate 2,4-dihalo-5-sulphamoyl-benzoic hydroxylamide with an amine R 1 NH 2 , or by reacting a reactive derivative of a 4-halo-5-sulphamoyl-anthranilic acid, such as a halide or a symmetrical or mixed anhydride, with a hydroxylamine compound R 2 ONH 2 . 2,4 - Dihalo - 5 - sulphamoyl - benzoic hydroxylamide starting materials are made by treating the corresponding 2,4-dihalo-5-sulphamoyl-benzoic acid with thionyl chloride and reacting the resulting acid chloride with an amine R 2 ONH 2 . 4 - Halo - 5 - sulphamoyl - anthranilic acid halides and anhydrides are prepared from the free acid by standard methods for preparing acid halides and anhydrides. Pharmaceutical preparations having diuretic and saliuretic activity comprise the above compounds of the invention and a carrier, preferably in forms adapted to oral or parenteral administration.

    3.
    发明专利
    未知

    公开(公告)号：SE345851B

    公开(公告)日：1972-06-12

    申请号：SE1573265

    申请日：1965-12-06

    Applicant: HOECHST AG

    Inventor： STURM K ,  SIEDEL W ,  WEYER R

    IPC: C07D307/52 ,  C07C143/80 ,  C07D5/16 ,  C07D63/12

    Abstract: 1,126,672. Sulphamoylanthranilic hydroxylamides. FARBWERKE HOECHST A.G. 6 Dec., 1965 [8 Dec., 1964], No. 51658/65. Heading C2C. Novel compounds of the formula wherein R 1 is a benzyl, furfuryl or thenyl-(2) group, R 2 is a hydrogen or C 1-3 alkyl, R 3 is hydrogen or methoxy and X is Cl or Br are made either by reacting an appropriate 2,4-dihalo-5-sulphamoyl-benzoic hydroxylamide with an amine R 1 NH 2 , or by reacting a reactive derivative of a 4-halo-5-sulphamoyl-anthranilic acid, such as a halide or a symmetrical or mixed anhydride, with a hydroxylamine compound R 2 ONH 2 . 2,4 - Dihalo - 5 - sulphamoyl - benzoic hydroxylamide starting materials are made by treating the corresponding 2,4-dihalo-5-sulphamoyl-benzoic acid with thionyl chloride and reacting the resulting acid chloride with an amine R 2 ONH 2 . 4 - Halo - 5 - sulphamoyl - anthranilic acid halides and anhydrides are prepared from the free acid by standard methods for preparing acid halides and anhydrides. Pharmaceutical preparations having diuretic and saliuretic activity comprise the above compounds of the invention and a carrier, preferably in forms adapted to oral or parenteral administration.

    5.
    发明专利
    未知

    公开(公告)号：FI44607B

    公开(公告)日：1971-08-31

    申请号：FI179167

    申请日：1967-07-27

    Applicant: HOECHST AG

    Inventor： STURM K ,  SIEDEL W

    IPC: C07D307/14 ,  C07D307/68 ,  C07C143/78

    Abstract: 1,188,158. N-Acylated halogeno benzene-2,4- disulphonamides. FARBWERKE HOECHST A.G. 11 July, 1967 [13 July, 1966], No. 31773/67. Heading C2C. Novel compounds I wherein X is a chlorine or bromine atom, R is alkyl, alkoxyalkyl or tetrahydrofurfuryl and R 1 is an alkyl, cycloalkyl or cycloalkyl-alkyl radical which may be substituted by one or more halogen atoms or be singly unsaturated and which may contain up to 8 carbon atoms, or represents a phenyl, furyl, thienyl, phenylalkyl, furylalkyl or thienylalkyl radical which may be substituted in the phenyl radical by one or more substituents selected from halogen atoms and alkyl and alkoxy radicals and in which the alkylene bridge of the phenylalkyl, furylalkyl or thienylalkyl radical may be branched and/or singly unsaturated, are prepared by reacting a sulphohalide II with a reactive derivative of a carboxylic acid, R 1 -COOH, and treating the intermediate sulphohalide with ammonia. Pharmaceutical preparations possessing diuretic and saluretic action contain as active ingredient compounds I and are preferably administered orally.

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