公开(公告)号：NO177597C

公开(公告)日：1995-10-18

申请号：NO893193

申请日：1989-08-08

Applicant: HOECHST AG

Inventor： HENKE STEPHAN ,  ANAGNOSTOPULOS HIRISTO ,  BREIPOHL GERHARD ,  KNOLLE JOCHEN ,  STECHL JENS ,  SCHOLKENS BERNWARD ,  FEHLHABER HANS-WOLFRAM

IPC: A61K38/17 ,  A61K38/00 ,  A61K38/08 ,  A61P9/00 ,  A61P9/02 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P25/04 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07K1/06 ,  C07K7/06 ,  C07K7/08 ,  C07K7/18

Abstract: Peptides of the formula I A-B-C-E-F-K-(D)-Tic-G-M-F'-I (I> in which A is hydrogen, alkyl, alkanoyl, alkoxycarbonyl, alkylsulphonyl, cycloalkyl, aryl, arylsulphonyl, heteroaryl or an amino acid, each of which can optionally be substituted, B is a basic amino acid, C is a di- or tripeptide, E is the residue of an aromatic amino acid, F is, independently of one another, an amino acid which is optionally substituted in the side chain or is a direct bond, G is an amino acid, F' is defined as F, can be -NH-(CH2)2-8 or optionally a direct bond, I is -OH, -NH2 or -NHC2H5 and K is a radical -NH(CH2)-1-4-CO- or is a direct bond, have bradykinin-antagonistic action. Their therapeutic uses comprise all pathological states which are promoted, induced or sustained by bradykinin and bradykinin- related peptides. The peptides of the formula I are prepared by known methods of peptide synthesis.

公开(公告)号：PT91692B

公开(公告)日：1995-05-31

申请号：PT9169289

申请日：1989-09-11

Applicant: HOECHST AG

Inventor： SCHOLKENS BERNWARD ,  HENKE STEPHAN ,  STECHL JENS ,  KNOLLE JOCHEN ,  FEHLHABER HANS-WOLFRAM ,  ANAGNOSTOPULOS HIRISTO ,  BREIPOHL GERHARD

IPC: A61K38/17 ,  A61K38/00 ,  A61K38/08 ,  A61P9/00 ,  A61P9/02 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P25/04 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07K1/06 ,  C07K7/06 ,  C07K7/08 ,  C07K7/18 ,  A61K37/02

Abstract: Peptides of the formula I A-B-C-E-F-K-(D)-Tic-G-M-F'-I (I> in which A is hydrogen, alkyl, alkanoyl, alkoxycarbonyl, alkylsulphonyl, cycloalkyl, aryl, arylsulphonyl, heteroaryl or an amino acid, each of which can optionally be substituted, B is a basic amino acid, C is a di- or tripeptide, E is the residue of an aromatic amino acid, F is, independently of one another, an amino acid which is optionally substituted in the side chain or is a direct bond, G is an amino acid, F' is defined as F, can be -NH-(CH2)2-8 or optionally a direct bond, I is -OH, -NH2 or -NHC2H5 and K is a radical -NH(CH2)-1-4-CO- or is a direct bond, have bradykinin-antagonistic action. Their therapeutic uses comprise all pathological states which are promoted, induced or sustained by bradykinin and bradykinin- related peptides. The peptides of the formula I are prepared by known methods of peptide synthesis.

公开(公告)号：MX9203277A

公开(公告)日：1992-07-01

申请号：MX9203277

申请日：1992-06-24

Applicant: HOECHST AG

Inventor： HENKE STEPHAN ,  ANAGNOSTOPULOS HIRISTO ,  BREIPHOL GERHARD ,  KNOLLE JOCHEN ,  STECHL JENS ,  SCHOLKENS BERNWARD

IPC: A61K38/17 ,  A61K38/00 ,  A61K38/08 ,  A61P9/00 ,  A61P9/02 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P25/04 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07K1/06 ,  C07K7/06 ,  C07K7/08 ,  C07K7/18 ,  C07K7/00

Abstract: Peptides of the formula I A-B-C-E-F-K-(D)-Tic-G-M-F'-I (I> in which A is hydrogen, alkyl, alkanoyl, alkoxycarbonyl, alkylsulphonyl, cycloalkyl, aryl, arylsulphonyl, heteroaryl or an amino acid, each of which can optionally be substituted, B is a basic amino acid, C is a di- or tripeptide, E is the residue of an aromatic amino acid, F is, independently of one another, an amino acid which is optionally substituted in the side chain or is a direct bond, G is an amino acid, F' is defined as F, can be -NH-(CH2)2-8 or optionally a direct bond, I is -OH, -NH2 or -NHC2H5 and K is a radical -NH(CH2)-1-4-CO- or is a direct bond, have bradykinin-antagonistic action. Their therapeutic uses comprise all pathological states which are promoted, induced or sustained by bradykinin and bradykinin- related peptides. The peptides of the formula I are prepared by known methods of peptide synthesis.

公开(公告)号：ZA8906068B

公开(公告)日：1991-01-30

申请号：ZA8906068

申请日：1989-08-09

Applicant: HOECHST AG

Inventor： HENKE STEPHAN ,  STEPHAN HENKE ,  ANAGNOSTOPULOS HIRISTO ,  HIRISTO ANAGNOSTOPULOS ,  BREIPOHL GERHARD ,  GERHARD BREIPOHL ,  KNOLLE JOCHEN ,  JOCHEN KNOLLE ,  STECHL JENS ,  JENS STECHL ,  SCHOELKENS BERNWARD ,  BERNWARD SCHOELKENS

IPC: C07K7/06 ,  A61K20060101 ,  A61K38/08 ,  A61K38/10 ,  C07K20060101 ,  C07K7/18 ,  C07K ,  A61K

公开(公告)号：HUT53292A

公开(公告)日：1990-10-28

申请号：HU31589

申请日：1989-01-25

Applicant: HOECHST AG

Inventor： RUEGER WOLFGANG ,  URBACH HANSJOERG ,  HENNING RAINER ,  STECHL JENS ,  USINGER PATRICIA ,  HOCK FRANZ

IPC: A61K20060101 ,  A61K37/64

公开(公告)号：AU3943189A

公开(公告)日：1990-05-31

申请号：AU3943189

申请日：1989-08-09

Applicant: HOECHST AG

Inventor： HENKE STEPHAN ,  ANAGNOSTOPULOS HIRISTO ,  BREIPOHL GERHARD ,  KNOLLE JOCHEN ,  STECHL JENS ,  SCHOLKENS BERNWARD

IPC: A61K38/17 ,  A61K38/00 ,  A61K38/08 ,  A61P9/00 ,  A61P9/02 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P25/04 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07K1/06 ,  C07K7/06 ,  C07K7/08 ,  C07K7/18 ,  A61K37/02

Abstract: Peptides of the formula I A-B-C-E-F-K-(D)-Tic-G-M-F'-I (I> in which A is hydrogen, alkyl, alkanoyl, alkoxycarbonyl, alkylsulphonyl, cycloalkyl, aryl, arylsulphonyl, heteroaryl or an amino acid, each of which can optionally be substituted, B is a basic amino acid, C is a di- or tripeptide, E is the residue of an aromatic amino acid, F is, independently of one another, an amino acid which is optionally substituted in the side chain or is a direct bond, G is an amino acid, F' is defined as F, can be -NH-(CH2)2-8 or optionally a direct bond, I is -OH, -NH2 or -NHC2H5 and K is a radical -NH(CH2)-1-4-CO- or is a direct bond, have bradykinin-antagonistic action. Their therapeutic uses comprise all pathological states which are promoted, induced or sustained by bradykinin and bradykinin- related peptides. The peptides of the formula I are prepared by known methods of peptide synthesis.

公开(公告)号：NO893193L

公开(公告)日：1990-05-25

申请号：NO893193

申请日：1989-08-08

Applicant: HOECHST AG

Inventor： HENKE STEPHAN ,  ANAGNOSTOPULOS HIRISTO ,  BREIPOHL GERHARD ,  KNOLLE JOCHEN ,  STECHL JENS ,  SCHOELKENS BERNWARD ,  FEHLHABER HANS-WOLFRAM

IPC: A61K38/17 ,  A61K38/00 ,  A61K38/08 ,  A61P9/00 ,  A61P9/02 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P25/04 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07K1/06 ,  C07K7/06 ,  C07K7/08 ,  C07K7/18

Abstract: Peptides of the formula I A-B-C-E-F-K-(D)-Tic-G-M-F'-I (I> in which A is hydrogen, alkyl, alkanoyl, alkoxycarbonyl, alkylsulphonyl, cycloalkyl, aryl, arylsulphonyl, heteroaryl or an amino acid, each of which can optionally be substituted, B is a basic amino acid, C is a di- or tripeptide, E is the residue of an aromatic amino acid, F is, independently of one another, an amino acid which is optionally substituted in the side chain or is a direct bond, G is an amino acid, F' is defined as F, can be -NH-(CH2)2-8 or optionally a direct bond, I is -OH, -NH2 or -NHC2H5 and K is a radical -NH(CH2)-1-4-CO- or is a direct bond, have bradykinin-antagonistic action. Their therapeutic uses comprise all pathological states which are promoted, induced or sustained by bradykinin and bradykinin- related peptides. The peptides of the formula I are prepared by known methods of peptide synthesis.

公开(公告)号：ZA8900574B

公开(公告)日：1989-09-27

申请号：ZA8900574

申请日：1989-01-25

Applicant: HOECHST AG

Inventor： RUEGER WOLFGANG ,  WOLFGANG RUEGER ,  URBACH HANSJOERG ,  HANSJOERG URBACH ,  HENNING RAINER ,  RAINER HENNING ,  STECHL JENS ,  JENS STECHL ,  USINGER PATRICIA ,  PATRICIA USINGER ,  HOCK FRANZ ,  FRANZ HOCK

IPC: A61K20060101 ,  A61K

公开(公告)号：DK175344B1

公开(公告)日：2004-08-30

申请号：DK384089

申请日：1989-08-04

Applicant: HOECHST AG

Inventor： BREIPOHL GERHARD ,  KNOLLE JOCHEN ,  HENKE STEPHAN ,  ANAGNOSTOPULOS HIRISTO ,  STECHL JENS ,  SCHOELKENS BERNWARD ,  FEHLHABER HANS-WOLFRAM

IPC: A61K38/17 ,  A61K38/00 ,  A61K38/08 ,  A61P9/00 ,  A61P9/02 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P25/04 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07K1/06 ,  C07K7/06 ,  C07K7/08 ,  C07K7/18 ,  C07K16/00

Abstract: Peptides of the formula I A-B-C-E-F-K-(D)-Tic-G-M-F'-I (I> in which A is hydrogen, alkyl, alkanoyl, alkoxycarbonyl, alkylsulphonyl, cycloalkyl, aryl, arylsulphonyl, heteroaryl or an amino acid, each of which can optionally be substituted, B is a basic amino acid, C is a di- or tripeptide, E is the residue of an aromatic amino acid, F is, independently of one another, an amino acid which is optionally substituted in the side chain or is a direct bond, G is an amino acid, F' is defined as F, can be -NH-(CH2)2-8 or optionally a direct bond, I is -OH, -NH2 or -NHC2H5 and K is a radical -NH(CH2)-1-4-CO- or is a direct bond, have bradykinin-antagonistic action. Their therapeutic uses comprise all pathological states which are promoted, induced or sustained by bradykinin and bradykinin- related peptides. The peptides of the formula I are prepared by known methods of peptide synthesis.

公开(公告)号：FI94353C

公开(公告)日：1995-08-25

申请号：FI893738

申请日：1989-08-08

Applicant: HOECHST AG

Inventor： HENKE STEPHAN ,  ANAGNOSTOPULOS HIRISTO ,  BREIPOHL GERHARD ,  KNOLLE JOCHEN ,  STECHL JENS ,  SCHOELKENS BERNWARD ,  FEHLHABER HANS-WOLFRAM

IPC: A61K38/17 ,  A61K38/00 ,  A61K38/08 ,  A61P9/00 ,  A61P9/02 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P25/04 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07K1/06 ,  C07K7/06 ,  C07K7/08 ,  C07K7/18