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    1.
    发明专利
    未知

    公开(公告)号：FI109541B

    公开(公告)日：2002-08-30

    申请号：FI911978

    申请日：1991-04-24

    Applicant: HOECHST AG

    Inventor： BREIPOHL GERHARD ,  HENKE STEPHAN ,  KNOLLE JOCHEN ,  SCHOELKENS BERNWARD ,  HOCK FRANZ

    IPC: A61K38/00 ,  A61K38/08 ,  A61K38/17 ,  A61P29/00 ,  A61P37/08 ,  C07K1/02 ,  C07K7/06 ,  C07K7/18

    Abstract: Peptides of the formula I A-B-C-E-F-K-(D)-Tic-G-M-F'-I (I> in which A is hydrogen, alkyl, alkanoyl, alkoxycarbonyl, alkylsulphonyl, cycloalkyl, aryl, arylsulphonyl, heteroaryl or an amino acid, each of which can optionally be substituted, B is a basic amino acid, C is a di- or tripeptide, E is the residue of an aliphatic or alicyclic-aliphatic amino acid, F is, independently of one another, an amino acid which is optionally substituted in the side chain or is a direct bond, G is an amino acid, F' is defined as F, can be -NH-(CH2)2-8 or a direct bond, I is -OH, -NH2 or -NHC2H5, and K is a radical -NH-(CH2)1-4-CO-, or is a direct bond, have a bradykinin-antagonistic action. Their therapeutic uses comprise all pathological states which are mediated, induced or assisted by bradykinin and bradykinin-related peptides. The peptides of the formula I are prepared by known methods of peptide synthesis.

    PEPTIDES WITH A BRADYKININ-ANTAGONISTIC ACTION
    9.
    发明专利
    PEPTIDES WITH A BRADYKININ-ANTAGONISTIC ACTION 未知

    公开(公告)号：CA2041268A1

    公开(公告)日：1991-10-27

    申请号：CA2041268

    申请日：1991-04-25

    Applicant: HOECHST AG

    Inventor： BREIPOHL GERHARD ,  HENKE STEPHAN ,  KNOLLE JOCHEN ,  SCHOELKENS BERNWARD ,  HOCK FRANZ

    IPC: A61K38/00 ,  A61K38/08 ,  A61K38/17 ,  A61P29/00 ,  A61P37/08 ,  C07K1/02 ,  C07K7/06 ,  C07K7/18 ,  C07K7/02

    Abstract: Peptides with a bradykinin-antagonistic action Peptides of the formula I A-B-C-E-F-K-(D)-Tic-G-M-F'-I ~~(I) in which A is hydrogen, alkyl, alkanoyl, alkoxycarbonyl, alkylsulfonyl, cycloalkyl, aryl, arylsulfonyl, heteroaryl or an amino acid, each of which can optionally be substi- tuted, B is a basic amino acid, C is a di- or tripeptide E is the residue of an aliphatic or alicyclic-aliphatic amino acid, F is, independently of one another, an amino acid which is optionally substituted in the side chain or a direct bond, G is an amino acid, F' is as defined as F, can be -NH-(CH2)2-8 or optionally a direct bond, I is -OH, -NH2 or -NHC2H5, and K is a radical -NH-(CH2)1-4-CO- or is a direct bond, have a bradykinin-antagonistic action. Their therapeutic uses comprise all pathological states which are mediated, induced or assisted by bradykinin or bradykinin-related peptides. The peptides of the formula I are prepared by known methods of peptide synthesis.

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