公开(公告)号：DK272778A

公开(公告)日：1978-12-19

申请号：DK272778

申请日：1978-06-16

Applicant: HOECHST AG

Inventor： WEBER R O ,  ANAGNOSTOPULOS H ,  GEBERT U

IPC: A61K31/495 ,  A61K31/505 ,  A61P25/04 ,  A61P43/00 ,  C07D239/22 ,  C07D239/54 ,  C07D239/56 ,  C07D295/13 ,  C07D401/06 ,  C07D403/00 ,  C07D

Abstract: Compounds of general formula are disclosed wherein appropriate substituents for R1, R2 to R5, R6, A, Q, X, and Z are defined for these novel hexahydropyrimidines. Procedures for the preparation of these compounds are also given. Because of the highly effective serotonin antagonistic activity in combination with a strong inhibiting effect on thrombocyte aggregation and good compatibility these compounds are effective in treating migraine. Additionally, the compounds also exhibit an anti-histamine activity, cause an increase in erythrocyte fluidity, a psychotropic activity, a weak bradykinin antagonism and hypotensive effects.

公开(公告)号：DK282279A

公开(公告)日：1979-07-12

申请号：DK282279

申请日：1979-07-04

Applicant: HOECHST AG

Inventor： WEBER R O ,  PERREY K

IPC: A61K31/34 ,  A61K31/343 ,  A61K31/495 ,  A61P25/24 ,  A61P25/26 ,  C07D241/04 ,  C07D307/83 ,  C07D307/85 ,  C07D405/06 ,  C07D

Abstract: A compound of the formula or its acid addition salt with a physiologically compatible acid, a process for its preparation by a reaction selected from the group consisting of (a) reacting N-benzyl-piperazine and 5-methoxycumarilic acid (a1) at an elevated temperature in the absence of a condensation agent, (a2) at a temperature of at least 15 DEG C. in the presence of a condensation agent; (b) reacting N-benzyl-piperazine with an activated derivative of 5-methoxy-cumarilic acid; (c) N-(5-methoxycumaroyl)-piperazine with a benzyl compound selected from the group consisting of benzyl halide, benzylalkyl sulfonate and benzyl-aryl sulfonate and a pharmaceutical composition containing said compounds.

公开(公告)号：DK511376A

公开(公告)日：1977-05-14

申请号：DK511376

申请日：1976-11-12

Applicant: HOECHST AG

Inventor： GEBERT U ,  MUSIL J ,  WEBER R O

IPC: C07D401/14 ,  A61K31/41 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4433 ,  A61P7/10 ,  A61P13/02 ,  A61P15/00 ,  A61P19/06 ,  A61P25/04 ,  A61P29/00 ,  C07D403/04 ,  C07D403/06 ,  C07D409/14 ,  C07D