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    CYCLIC DIAMINE N,N'-DISUBSTITUTED AND PROCESS FOR PREPARING THE SAME
    1.
    发明申请
    CYCLIC DIAMINE N,N'-DISUBSTITUTED AND PROCESS FOR PREPARING THE SAME 审中-公开
    循环二胺N，非取代和其制备方法

    公开(公告)号：WO1979000426A1

    公开(公告)日：1979-07-12

    申请号：PCT/DE1978000040

    申请日：1978-12-16

    Applicant: HOECHST AG

    Inventor： HOECHST AG ,  PERREY K ,  WEBER R ,  RECHENBERG W

    IPC: C07D405/06

    CPC classification number: C07D307/85

    Abstract: Compound having the formula (FORMULA) or its salts of addition of acids physiologically acceptable and process for its preparation, wherein is reacted: a) N-benzylpiperazine and 5-methoxy-benzofurane-2-carboxylic acid, a1) at a higher temperature and without using a condensing agent or a2) at a temperature of at least 15` C in presence of appropriate condensing agents, b) N-benzylpiperazine with an activated sub-product of 5-methoxybenzofurane-2-carboxylic acid or c) N-(5-methoxy-2-benzofuroyl)-piperazine with a benzyl halide, an alkyl-sulfonate of benzyl or an aryl-sulfonate of benzyl. Medicine, containing the above compound.

    Abstract translation: 具有式（式）的化合物或其生理上可接受的酸加成盐及其制备方法，其中反应：a）N-苄基哌嗪和5-甲氧基 - 苯并呋喃-2-羧酸，a1）在较高温度和 不使用缩合剂或a2）在适当的缩合剂存在下在至少15℃的温度下进行，b）N-苄基哌嗪与5-甲氧基苯并呋喃-2-羧酸的活化副产物或c）N-（ 5-苄氧基-2-甲氧基-2-苯并呋喃基） - 哌嗪与苄基卤，苄基的烷基磺酸盐或苄基的芳基磺酸盐。 含有上述化合物的药物。

    2.
    发明专利
    未知

    公开(公告)号：DK282279A

    公开(公告)日：1979-07-12

    申请号：DK282279

    申请日：1979-07-04

    Applicant: HOECHST AG

    Inventor： WEBER R O ,  PERREY K

    IPC: A61K31/34 ,  A61K31/343 ,  A61K31/495 ,  A61P25/24 ,  A61P25/26 ,  C07D241/04 ,  C07D307/83 ,  C07D307/85 ,  C07D405/06 ,  C07D

    Abstract: A compound of the formula or its acid addition salt with a physiologically compatible acid, a process for its preparation by a reaction selected from the group consisting of (a) reacting N-benzyl-piperazine and 5-methoxycumarilic acid (a1) at an elevated temperature in the absence of a condensation agent, (a2) at a temperature of at least 15 DEG C. in the presence of a condensation agent; (b) reacting N-benzyl-piperazine with an activated derivative of 5-methoxy-cumarilic acid; (c) N-(5-methoxycumaroyl)-piperazine with a benzyl compound selected from the group consisting of benzyl halide, benzylalkyl sulfonate and benzyl-aryl sulfonate and a pharmaceutical composition containing said compounds.

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