PROCESS FOR PREPARING ACYLATED GLYCOSYL FLUORIDES

    公开(公告)号:CA2086618A1

    公开(公告)日:1992-01-03

    申请号:CA2086618

    申请日:1991-06-12

    Applicant: HOECHST AG

    Inventor: WIESNER MATTHIAS

    Abstract: HOE 90/F 196 Process for preparing acylated glycosyl fluorides Process for preparing acylated glycosyl fluorides by fluorination of saccharides, which are at least partially O-acylated, in anhydrous hydrogen fluoride, characterized in that the corresponding carboxylic anhydride is added to the hydrogen fluoride before the reaction and the reaction solution is processed after reaction times of at most 60 minutes.

    PROCESS FOR PRODUCING 1-FLUORO-GLYCURONIC ACIDS AND THEIR SALTS AND SUCH NEW 1-FLUORO-GLYCONIC ACIDS AND THEIR SALTS

    公开(公告)号:CA2057001A1

    公开(公告)日:1990-11-19

    申请号:CA2057001

    申请日:1990-05-11

    Applicant: HOECHST AG

    Abstract: HOE 89/F 149 of the disclosure: Process for the preparation of 1-fluoro-glycuronic acids and salts thereof, and such novel 1-fluoro-glycuronic acids and salts thereof Process for the preparation of 1-fluoro-glycuronic acids, which can contain protected amino groups, and salts thereof, characterized in that glycopyranosyl fluorides of mono- or oligosaccharides which carry at least one primary OH function are oxidized with oxygen as the oxidizing agent in an aqueous solution in the pH range from 6 to 9 in the presence of a catalyst which contains at least one platinum metal, and the 1-fluoro-glycuronic acids formed are at least partly neutralized. The invention furthermore relates to compounds of the general formula (I) in which M represents hydrogen or a cation, in particular an alkali metal, and X denotes oxygen or NH, independently of one another, wherein, if X = oxygen, R denotes hydrogen or a glycosidically bonded monosaccharide and if X = NH, R represents an acyl, alkyl, aryl or aralkyl protective group radical having up to 10 carbon atoms, but wherein only one of the groups RX has a meaning other than OH.

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