公开(公告)号：HUT61336A

公开(公告)日：1992-12-28

申请号：HU394691

申请日：1991-12-13

Applicant: HOECHST AG

Inventor： ZEEK AXEL ,  BREIDING-MACK SABINE ,  GOEHRT AXEL ,  GRABLEY SUSANNE ,  GRANZER ERNOLD ,  HUETTER KLAUS ,  THIERICKE RALF ,  WINK JOACHIM

IPC: A61K31/35 ,  A61K31/352 ,  A61P3/06 ,  C07D311/74 ,  C07D493/08 ,  C07H19/01 ,  C12P17/06 ,  C12P19/02 ,  C12P19/44 ,  C12R1/77 ,  C12P17/02

Abstract: It is possible with the aid of a Fusarium strain to prepare metabolites of the following formula I in which R is hydrogen or hydroxyl, R is hydroxyl or an oxo group, R is methoxy or hydroxyl or, together with R , forms an ether bridge and R is hydrogen or hydroxyl, R is hydrogen or, together with R , represents an additional bond and R is hydrogen or, together with R , is an additional bond. The metabolites are to be used, in particular, for inhibiting cholesterol biosynthesis.

公开(公告)号：HU201354B

公开(公告)日：1990-10-28

申请号：HU376887

申请日：1987-08-26

Applicant: HOECHST AG

Inventor： BREIDING-MACK SABINE ,  GRABLEY SUSANNE ,  SEIBERT GERHARD ,  VOELSKOW HARTMUT ,  ZEEK AXEL

IPC: A61K31/535 ,  A61K31/538 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P33/02 ,  A61P33/10 ,  A61P43/00 ,  C07D265/38 ,  C12N1/20 ,  C12P17/14 ,  C12P17/18 ,  C12R1/465

Abstract: Streptomyces spec. DSM 3813 produces novel compounds with a basic phenoxazinone structure, which have an antifungal and antiviral action and can be used as lipoxygenase inhibitors.

公开(公告)号：HUT59957A

公开(公告)日：1992-07-28

申请号：HU336791

申请日：1991-10-25

Applicant: HOECHST AG

Inventor： ZEEK AXEL ,  PHILIPPS SIEGRID ,  GRABLEY SUSANNE ,  GRANZER ERNOLD ,  HUETTER KLAUS ,  THIERICKE RALF ,  WINK JOACHIM

IPC: A61K31/34 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07D407/06 ,  C07H17/04 ,  C07H17/08 ,  C12N1/20 ,  C12P17/08 ,  C12P19/60 ,  C12P19/62 ,  C12R1/465 ,  C12R1/625 ,  C12P17/16 ,  A61K31/71

Abstract: Macrolactones of the formula I with pharmacological action can be prepared with the aid of Streptoverticillium and Streptomyces strains in which R is hydrogen or the group

公开(公告)号：HU913946D0

公开(公告)日：1992-02-28

申请号：HU394691

申请日：1991-12-13

Applicant: HOECHST AG

Inventor： ZEEK AXEL ,  BREIDING-MACK SABINE ,  GOEHRT AXEL ,  GRABLEY SUSANNE ,  GRANZER ERNOLD ,  HUETTER KLAUS ,  THIERICKE RALF ,  WINK JOACHIM

IPC: A61K31/35 ,  A61K31/352 ,  A61P3/06 ,  C07D311/74 ,  C07D493/08 ,  C07H19/01 ,  C12P17/06 ,  C12P19/02 ,  C12P19/44 ,  C12R1/77

Abstract: It is possible with the aid of a Fusarium strain to prepare metabolites of the following formula I in which R is hydrogen or hydroxyl, R is hydroxyl or an oxo group, R is methoxy or hydroxyl or, together with R , forms an ether bridge and R is hydrogen or hydroxyl, R is hydrogen or, together with R , represents an additional bond and R is hydrogen or, together with R , is an additional bond. The metabolites are to be used, in particular, for inhibiting cholesterol biosynthesis.

公开(公告)号：HU913367D0

公开(公告)日：1992-01-28

申请号：HU336791

申请日：1991-10-25

Applicant: HOECHST AG

Inventor： ZEEK AXEL ,  PHILIPPS SIEGRID ,  GRABLEY SUSANNE ,  GRANZER ERNOLD ,  HUETTER KLAUS ,  THIERICKE RALF ,  WINK JOACHIM

IPC: A61K31/34 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07D407/06 ,  C07H17/04 ,  C07H17/08 ,  C12N1/20 ,  C12P17/08 ,  C12P19/60 ,  C12P19/62 ,  C12R1/465 ,  C12R1/625

Abstract: Macrolactones of the formula I with pharmacological action can be prepared with the aid of Streptoverticillium and Streptomyces strains in which R is hydrogen or the group

公开(公告)号：HUT44624A

公开(公告)日：1988-03-28

申请号：HU376887

申请日：1987-08-26

Applicant: HOECHST AG

Inventor： ZEEK AXEL ,  BREIDING-MACK SABINE ,  GRABLEY SUSANNE ,  VOELSKOW HARTMUT ,  SEIBERT GERHARD

IPC: A61K31/535 ,  A61K31/538 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P33/02 ,  A61P33/10 ,  A61P43/00 ,  C07D265/38 ,  C12N1/20 ,  C12P17/14 ,  C12P17/18 ,  C12R1/465

Abstract: Streptomyces spec. DSM 3813 produces novel compounds with a basic phenoxazinone structure, which have an antifungal and antiviral action and can be used as lipoxygenase inhibitors.