公开(公告)号：JPH10204099A

公开(公告)日：1998-08-04

申请号：JP34263197

申请日：1997-12-12

Applicant: HOECHST AG

Inventor： VERTESY LASZLO ,  KNAUF MARTIN ,  WINK JOACHIM ,  ISERT DIETER ,  STAHL WILHELM ,  RIESS GUNTHER ,  ASZODI JOZSEF ,  BELLER DOMINIQUE LE

IPC: C12P1/06 ,  A61K38/00 ,  A61K38/10 ,  A61P31/00 ,  C07K7/08 ,  C12N1/20 ,  C12P21/02 ,  C12R1/465 ,  C12R1/645

Abstract: PROBLEM TO BE SOLVED: To provide the subject new non-toxic substance produced by a specific microorganism of the genus Streptomyces, active as an antibiotic substance, having high tolerance and effectively inhibiting human immunodeficiency virus. SOLUTION: This substance is a compound of the formula, its salt or its chemically equivalent substance. It has the following properties. Appearance, colorless; solubility, soluble in methanol, acetonitrile and water; stability, stable under neutral or moderately alkaline conditions and unstable in strongly acidic or strongly alkaline solution; molecular formula, C95 H97 N13 O30 ; molecular weight, 1900.90; etc. The compound can be produced by the fermentation with a microorganism HAG 4674 (DSM 11171) of the genus Streptomyces, its variant or mutant. The fermentation is preferably carried out in a nutrient solution containing 1-2% of oat flake and a minor element solution of 0.2-0.3% concentration under aerobic condition at 25-30 deg.C and pH5.5-8.5 for 24-140hr.

公开(公告)号：JPH10120686A

公开(公告)日：1998-05-12

申请号：JP22225897

申请日：1997-08-19

Applicant: HOECHST AG

Inventor： VERTESY LASZLO ,  KURZ MICHAEL ,  WINK JOACHIM ,  MARKUS ASTRID ,  STAHL WILHELM

IPC: C12P17/18 ,  A61K31/365 ,  A61P31/04 ,  A61P31/10 ,  A61P33/02 ,  C07D493/04 ,  C07H17/08 ,  C12N1/20 ,  C12P19/62 ,  C12R1/465

Abstract: PROBLEM TO BE SOLVED: To obtain a novel polyene antibiotic substances 3874H1 to H6 which are produced by Streptomyces DSM11007 and is useful as an antifungal agent of a therapeutic agent for treatment of diseases relating to increased steroidal concentration. SOLUTION: This novel polyene antibiotic agent is produced by Streptomyces DSM11007 and comprises the following 6 substances: antibiotic substance 3874H1 is represented by formula I, has the molecular formula of C58 H86 N2 O18 and the molecular weight of 1099.3; the antibiotic substance 3874H2 is represented by formula II, has the molecular formula of C59 H88 N2 O18 and the molecular weight of 1113.3; the antibiotic substance 3874H3 is represented by formula III, has the molecular formula of C57 H87 N2 O18 and the molecular weight of 1074.3; the antibiotic substance 3874H4 is represented by formula IV, has the molecular formula of C58 H84 N2 O18 and the molecular weight of 1097.3; the antibiotic substance 3874H5 is represented by formula V, has the molecular formula of C57 H85 N2 O18 and the molecular weight of 1072.3. The agent is useful as an antifungal agent and for treatment of diseases relating to increased steroidalal concentration. These antibiotic substances are obtained by fermentation of Streptomyces DSM11007 or its mutant under appropriate conditions and isolating the products from the culture mixture, respectively.

公开(公告)号：PT864584E

公开(公告)日：2001-05-31

申请号：PT98110484

申请日：1994-06-01

Applicant: HOECHST AG

Inventor： SEIBERT GERHARD ,  WINK JOACHIM ,  MEIWES JOHANNES ,  MARKUS ASTRID ,  LASZLO VERTESY DR ,  HAMMANN PETER

IPC: C12P21/02 ,  A61K38/00 ,  A61K38/08 ,  A61K38/12 ,  A61P31/04 ,  C07K20060101 ,  C07K1/20 ,  C07K7/06 ,  C07K7/60 ,  C07K14/195 ,  C07K14/41 ,  C12N1/20 ,  C12P1/06 ,  C12P21/04 ,  C12R1/045

Abstract: Lipo-peptides of formula (I), where R1 is a saturated or unsaturated, branched or unbranched, 6-22C fatty acid or hydroxy fatty acid residue other than those of formula (II)-(VII), are new:

公开(公告)号：BR9704385A

公开(公告)日：1999-05-11

申请号：BR9704385

申请日：1997-08-18

Applicant: HOECHST AG

Inventor： VERTESY LASZLO ,  KURZ MICHAEL ,  WINK JOACHIM ,  MARKUS ASTRID DR ,  STAHL WILHELM

IPC: C12P17/18 ,  A61K31/365 ,  A61P31/04 ,  A61P31/10 ,  A61P33/02 ,  C07D493/04 ,  C07H17/08 ,  C12N1/20 ,  C12P19/62 ,  C12R1/465

Abstract: Polyene derivatives of formula (I-VI): their salts and obvious chemical equivalents are new. Molecular formula: (MF) C59H88N2O18 (II), molecular weight (mol. wt.) 1113.3; MF: C57H87NO18 (III), mol. wt. 1074.3; MF: C58H84N2O18 (IV), mol.wt. 1097.3; MF: C59H86N2O18 (V), mol. wt. 1111.3, and MF: C57H85NO18 (VI), mol. wt. 1072.3. X = a group of formula (a) or (b), and Y = CH=CH-CH=CH-Me or a group of formula (c) or (d). Also claimed is the micro-organism Streptomyces DSM 11007.

公开(公告)号：CA2213285A1

公开(公告)日：1998-02-19

申请号：CA2213285

申请日：1997-08-18

Applicant: HOECHST AG

Inventor： WINK JOACHIM ,  MARKUS ASTRID ,  KURZ MICHAEL ,  VERTESY LSSSZLO ,  STAHL WILHELM

IPC: C12P17/18 ,  A61K31/365 ,  A61P31/04 ,  A61P31/10 ,  A61P33/02 ,  C07D493/04 ,  C07H17/08 ,  C12N1/20 ,  C12P19/62 ,  C12R1/465 ,  C07H19/01 ,  A61K31/71

Abstract: Novel polyene antibiotics, 3874 H1 to H6, processes for their preparation and use Compounds of the formulae 3874 H1, molecular formula C58H86N2O18, MW 1099.3 (see fig. I) 3874 H2, molecular formula: C59H88N2O18, MW 1113.3 (see fig. II) 3874 H3, molecular formula: C57H87NO18, MW 1074.3 (see fig. III) 3874 H4, molecular formula: C58H84N2O18, MW 1097.3 3874 H5, molecular formula: C59H86N2O18, MW 1111.3 3874 H6, molecular formula: C57H85NO18, MW 1072.3 are suitable for treating fungal diseases and for treating diseases associated with an increased steroid concentration.

公开(公告)号：DE59104720D1

公开(公告)日：1995-03-30

申请号：DE59104720

申请日：1991-06-12

Applicant: HOECHST AG

Inventor： ULBRICH NORBERT ,  HILGENFELD ROLF ,  HAENEL HEINZ ,  SACHSE BURKHARD ,  BRAUN PETER ,  WINK JOACHIM ,  ECKES PETER ,  LOGEMANN JUERGEN ,  SCHELL JOZEF

IPC: A01H5/00 ,  A01N63/00 ,  A01N63/04 ,  A61K38/00 ,  C07K14/00 ,  C07K14/195 ,  C07K14/37 ,  C07K14/41 ,  C07K14/415 ,  C12N5/10 ,  C12N15/09 ,  C12N15/31 ,  C12N15/82 ,  C12P21/02 ,  C12R1/66

Abstract: The polypeptide with the sequence (SEQ ID NO: 1) - Ala-Thr-Tyr-Asn-Gly-Lys-Cys-Tyr-Lys-Lys-Asp- - Asn-Ile-Cys-Lys-Tyr-Lys-Ala-Gln-Ser-Gly-Lys- - Thr-Ala-Ile-Cys-Lys-Cys-Tyr-Val-Lys-Lys-Cys- - Pro-Arg-Asp-Gly-Ala-Lys-Cys-Glu-Phe-Asp-Ser- - Tyr-Lys-Gly-Lys-Cys-Tyr-Cys - can be produced by the fermentation of Aspergillus giganteus and used as an antifungal agent. Expression of this polypeptide gene in plants strongly inhibits the growth of phytopathogenic fungi on the plant.

公开(公告)号：ZA9403983B

公开(公告)日：1995-01-27

申请号：ZA9403983

申请日：1994-06-07

Applicant: HOECHST AG

Inventor： HAMMANN PETER ,  MEIWES JOHANNES ,  SEIBERT GERHARD ,  VERTESY LASZLO ,  WINK JOACHIM ,  MARKUS ASTRID

IPC: C12P21/02 ,  A61K38/00 ,  A61K38/08 ,  A61K38/12 ,  A61P31/04 ,  C07K20060101 ,  C07K1/20 ,  C07K7/06 ,  C07K7/60 ,  C07K14/195 ,  C07K14/41 ,  C12N1/20 ,  C12P1/06 ,  C12P21/04 ,  C12R1/045 ,  C07K ,  A61K

CPC classification number: C07K7/60 ,  A61K38/00 ,  Y10S435/827

公开(公告)号：AU6462094A

公开(公告)日：1994-12-15

申请号：AU6462094

申请日：1994-06-06

Applicant: HOECHST AG

Inventor： HAMMANN PETER ,  MEIWES JOHANNES ,  SEIBERT GERHARD ,  VERTESY LASZLO ,  WINK JOACHIM ,  MARKUS ASTRID

IPC: C12P21/02 ,  A61K38/00 ,  A61K38/08 ,  A61K38/12 ,  A61P31/04 ,  C07K20060101 ,  C07K1/20 ,  C07K7/06 ,  C07K7/60 ,  C07K14/195 ,  C07K14/41 ,  C12N1/20 ,  C12P1/06 ,  C12P21/04 ,  C12R1/045 ,  A61K37/02 ,  A61K9/50 ,  A61K9/66 ,  A61K9/28

Abstract: Lipo-peptides of formula (I), where R1 is a saturated or unsaturated, branched or unbranched, 6-22C fatty acid or hydroxy fatty acid residue other than those of formula (II)-(VII), are new:

公开(公告)号：NO942110L

公开(公告)日：1994-12-09

申请号：NO942110

申请日：1994-06-07

Applicant: HOECHST AG

Inventor： HAMMANN PETER ,  MEIWES JOHANNES ,  SEIBERT GERHARD ,  VERTESY LASZLO ,  WINK JOACHIM ,  MARKUS ASTRID

IPC: C12P21/02 ,  A61K38/00 ,  A61K38/08 ,  A61K38/12 ,  A61P31/04 ,  C07K20060101 ,  C07K1/20 ,  C07K7/06 ,  C07K7/60 ,  C07K14/195 ,  C07K14/41 ,  C12N1/20 ,  C12P1/06 ,  C12P21/04 ,  C12R1/045 ,  C07K7/50 ,  A61K

Abstract: Lipo-peptides of formula (I), where R1 is a saturated or unsaturated, branched or unbranched, 6-22C fatty acid or hydroxy fatty acid residue other than those of formula (II)-(VII), are new:

公开(公告)号：NO942110A

公开(公告)日：1994-12-09

申请号：NO942110

申请日：1994-06-07

Applicant: HOECHST AG

Inventor： HAMMANN PETER ,  MEIWES JOHANNES ,  SEIBERT GERHARD ,  VERTESY LASZLO ,  WINK JOACHIM ,  MARKUS ASTRID

IPC: C12P21/02 ,  A61K38/00 ,  A61K38/08 ,  A61K38/12 ,  A61P31/04 ,  C07K20060101 ,  C07K1/20 ,  C07K7/06 ,  C07K7/60 ,  C07K14/195 ,  C07K14/41 ,  C12N1/20 ,  C12P1/06 ,  C12P21/04 ,  C12R1/045 ,  C07K7/50 ,  A61K

CPC classification number: C07K7/60 ,  A61K38/00 ,  Y10S435/827