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公开(公告)号：JP2010229135A
公开(公告)日：2010-10-14
申请号：JP2010105307
申请日：2010-04-30
Inventor： DIEBOLD ERIC R , GHOSHAL MITALI , DENG DAVID Z , TSAI JANE SHIOW-CHUAN
IPC: C07D233/64 , C07D213/22 , C07F15/00 , G01N27/30 , G01N27/327 , G01N27/416 , G01N27/48 , G01N33/53 , G01N33/532 , G01N33/543 , G01N33/58
CPC classification number: G01N33/5306 , C07F15/002 , C07F15/0026 , C12Q1/004 , G01N33/5438 , G01N2458/30
Abstract: PROBLEM TO BE SOLVED: To provide a new osmium-based electrochemical species for detecting a wide variety of analytes using immunological techniques using an electrochemical oxidation/reduction label (also called an electron transfer agent or an electrochemical mediator label). SOLUTION: The new osmium-based electrochemical species usable in an immunoassay is provided. The osmium species can bond with a specific binding ligand for detecting related analytes and further can contain 1, 2 or 4 osmium centers that bond with the specific binding ligand using various bonding groups. Test sensors and diagnostic kits supporting electrode structures that can be used with the osmium-based electrochemical species are also provided. The test sensor can be fabricated to support interdigitated arrays of electrodes that have been designed to provide amplification of the electrical signal desired to analyze analytes that may be present at low concentration. COPYRIGHT: (C)2011,JPO&INPIT
Abstract translation: 要解决的问题：提供一种新的基于锇的电化学物种，用于使用电化学氧化/还原标记（也称为电子转移剂或电化学介体标记）的免疫学技术检测各种各样的分析物。 解决方案：提供了可用于免疫测定的新的基于锇的电化学物质。 锇物质可与用于检测相关分析物的特异性结合配体结合，并且还可以含有使用各种键合基团与特异性结合配体键合的1,2或4个锇中心。 还提供了可用于锇基电化学物种的测试传感器和支持电极结构的诊断套件。 测试传感器可以被制造成支持已经被设计为提供期望分析可能以低浓度存在的分析物的电信号的放大的交叉指示的电极阵列。 版权所有（C）2011，JPO＆INPIT
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公开(公告)号：JP2011128168A
公开(公告)日：2011-06-30
申请号：JP2011039285
申请日：2011-02-25
Inventor： DIEBOLD ERIC R , GHOSHAL MITALI , DENG DAVID Z , TSAI JANE SHIOW-CHUAN
IPC: G01N33/53 , C07F15/00 , G01N27/30 , G01N27/48 , G01N33/532 , G01N33/543 , G01N33/58
CPC classification number: G01N33/5306 , C07F15/002 , C07F15/0026 , C12Q1/004 , G01N33/5438 , G01N2458/30
Abstract: PROBLEM TO BE SOLVED: To provide novel osmium-based electrochemical species for the detection of a wide variety of analytes using immunological techniques, and provide a test sensor and diagnostic kit for supporting electrode structures that can be used with the osmium-based electrochemical species. SOLUTION: The test sensor can be fabricated to support interdigitated arrays of electrodes that have been designed to provide amplification of an electrical signal desired to analyze analytes that may be present at low concentrations. COPYRIGHT: (C)2011,JPO&INPIT
Abstract translation: 要解决的问题：提供新的基于锇的电化学物质，用于使用免疫学技术检测各种各样的分析物，并提供用于支持电极结构的测试传感器和诊断试剂盒，其可以与锇基 电化学物种。 解决方案：测试传感器可以被制造成支持指定的电极阵列，其被设计为提供期望分析可能以低浓度存在的分析物的电信号的放大。 版权所有（C）2011，JPO＆INPIT
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公开(公告)号：JP2010248196A
公开(公告)日：2010-11-04
申请号：JP2010105310
申请日：2010-04-30
Inventor： DIEBOLD ERIC R , GHOSHAL MITALI , DENG DAVID Z , TSAI JANE SHIOW-CHUAN
IPC: C07D233/64 , C07D213/22 , C07D311/80 , C07D473/08 , C07D475/08 , C07D495/04 , C07F15/00 , G01N27/30 , G01N27/327 , G01N27/416 , G01N27/48 , G01N33/53 , G01N33/532 , G01N33/543 , G01N33/58
CPC classification number: G01N33/5306 , C07F15/002 , C07F15/0026 , C12Q1/004 , G01N33/5438 , G01N2458/30
Abstract: PROBLEM TO BE SOLVED: To provide novel osmium-based electrochemical species for the detection of wide variety of analytes by using immunological technologies. SOLUTION: Compounds such as compound 57 are provided. The electrochemical species may contain 1, 2, or 4 osmium centers which bind to specifically binding ligands by using various connecting groups. COPYRIGHT: (C)2011,JPO&INPIT
Abstract translation: 要解决的问题：通过使用免疫技术，提供新的锇基电化学物质，用于检测各种各样的分析物。 解决方案：提供诸如化合物57的化合物。 电化学物种可以含有通过使用各种连接基团结合特异性结合配体的1,2或4个锇中心。 版权所有（C）2011，JPO＆INPIT
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Patent Agency Ranking
公开(公告)号：WO2005026178A3
公开(公告)日：2005-11-24
申请号：PCT/US2004021187
申请日：2004-07-01
Applicant: ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , DIEBOLD ERIC R , GHOSHAL MITALI , DENG DAVID Z , TSAI JANE SHIOW-CHUAN
Inventor： DIEBOLD ERIC R , GHOSHAL MITALI , DENG DAVID Z , TSAI JANE SHIOW-CHUAN
IPC: C07F15/00 , G01N27/30 , G01N27/48 , G01N33/53 , G01N33/532 , G01N33/543 , G01N33/58
CPC classification number: G01N33/5306 , C07F15/002 , C07F15/0026 , C12Q1/004 , G01N33/5438 , G01N2458/30
Abstract: The present invention provides novel osmium-based electrochemical species for the detection of wide variety of analytes using immunological techniques. The present invention also provides diagnostic kits and test sensors supporting electrode structures that can be used with the osmium-based electrochemical species. The test sensor can be fabricated to support interdigitated arrays of electrodes that have been designed to provide amplification of the electrical signal amplification desired to analyze analytes that may be present at low concentrations.
Abstract translation: 本发明提供了用于使用免疫学技术检测各种分析物的新型锇基电化学物质。 本发明还提供了支持电极结构的诊断套件和测试传感器，其可以与锇基电化学物质一起使用。 可以制造测试传感器以支持指叉阵列的电极，所述电极已被设计为提供所需电信号放大的放大以分析可能以低浓度存在的分析物。
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公开(公告)号：ES2392170T3
公开(公告)日：2012-12-05
申请号：ES04809471
申请日：2004-07-01
Applicant: ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE
Inventor： DIEBOLD ERIC R , GHOSHAL MITALI , DENG DAVID Z , TSAI JANE SHIOW-CHUAN
IPC: G01N33/53 , C07F15/00 , G01N27/30 , G01N27/48 , G01N33/532 , G01N33/543 , G01N33/58
Abstract: Un compuesto de fórmula II: en el que R y R1 son los mismos o diferentes y cada uno puede seleccionarse entre: 2,2'-bipiridilo, 4,4'-disustituido-2,2'- bipiridilo, 5-5'-disustituido-2,2'-bipiridilo, 1,10-fenantrolinilo, 4,7-disustituido-1,10-fenantrolinilo, 5,6-disustituido- 1,10-fenantrolinilo, o N, N'-dimetil 2,2'-biimidazol, en el que cada sustituyente es un grupo metilo, etilo, o fenilo, y en el que los grupos R y R1 están coordinados con osmio a través de sus átomos de nitrógeno; R2 es hidrógeno, metilo, o etilo; --L--es un enlazante; E es un enlazante trivalente; B es un grupo que comprende un ligando capaz de unirse a una pareja de unión de analito específica; Z es cloro o bromo; X es un contraión; y y se selecciona para proporcionar una sal neutra; y m es de 2 a 4.
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公开(公告)号：CA2694876A1
公开(公告)日：2005-03-24
申请号：CA2694876
申请日：2004-07-01
Applicant: HOFFMANN LA ROCHE
Inventor： DIEBOLD ERIC R , GHOSHAL MITALI , DENG DAVID Z , TSAI JANE SHIOW-CHUAN
IPC: C07F15/00 , G01N27/30 , G01N27/48 , G01N33/53 , G01N33/532 , G01N33/543 , G01N33/58
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公开(公告)号：CA2530211A1
公开(公告)日：2005-03-24
申请号：CA2530211
申请日：2004-07-01
Applicant: HOFFMANN LA ROCHE
Inventor： DIEBOLD ERIC R , GHOSHAL MITALI , TSAI JANE SHIOW-CHUAN , DENG DAVID Z
IPC: C07F15/00 , G01N27/30 , G01N27/48 , G01N33/53 , G01N33/532 , G01N33/543 , G01N33/58
Abstract: The present invention provides novel osmium-based electrochemical species fo r the detection of wide variety of analytes using immunological techniques. Th e present invention also provides diagnostic kits and test sensors supporting electrode structures that can be used with the osmium-based electrochemical species. The test sensor can be fabricated to support interdigitated arrays of electrodes that have been designed to provide amplification of the electrica l signal amplification desired to analyze analytes that may be present at low concentrations.
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公开(公告)号：CA2530211C
公开(公告)日：2011-10-04
申请号：CA2530211
申请日：2004-07-01
Applicant: HOFFMANN LA ROCHE
Inventor： DIEBOLD ERIC R , GHOSHAL MITALI , DENG DAVID Z , TSAI JANE SHIOW-CHUAN
IPC: C07F15/00 , G01N27/30 , G01N27/48 , G01N33/53 , G01N33/532 , G01N33/543 , G01N33/58
Abstract: The present invention provides novel osmium-based electrochemical species for the detection of wide variety of analytes using immunological techniques. The present invention also provides diagnostic kits and test sensors supporting electrode structures that can be used with the osmium-based electrochemical species. The test sensor can be fabricated to support interdigitated arrays of electrodes that have been designed to provide amplification of the electrical signal amplification desired to analyze analytes that may be present at low concentrations.
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