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    Electrochemical affinity biosensor system and method
    1.
    发明专利
    Electrochemical affinity biosensor system and method 审中-公开
    电化学生物传感器系统及方法

    公开(公告)号：JP2010229135A

    公开(公告)日：2010-10-14

    申请号：JP2010105307

    申请日：2010-04-30

    Applicant: F Hoffmann La Roche Ag ,  エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft

    Inventor： DIEBOLD ERIC R ,  GHOSHAL MITALI ,  DENG DAVID Z ,  TSAI JANE SHIOW-CHUAN

    IPC: C07D233/64 ,  C07D213/22 ,  C07F15/00 ,  G01N27/30 ,  G01N27/327 ,  G01N27/416 ,  G01N27/48 ,  G01N33/53 ,  G01N33/532 ,  G01N33/543 ,  G01N33/58

    CPC classification number: G01N33/5306 ,  C07F15/002 ,  C07F15/0026 ,  C12Q1/004 ,  G01N33/5438 ,  G01N2458/30

    Abstract: PROBLEM TO BE SOLVED: To provide a new osmium-based electrochemical species for detecting a wide variety of analytes using immunological techniques using an electrochemical oxidation/reduction label (also called an electron transfer agent or an electrochemical mediator label). SOLUTION: The new osmium-based electrochemical species usable in an immunoassay is provided. The osmium species can bond with a specific binding ligand for detecting related analytes and further can contain 1, 2 or 4 osmium centers that bond with the specific binding ligand using various bonding groups. Test sensors and diagnostic kits supporting electrode structures that can be used with the osmium-based electrochemical species are also provided. The test sensor can be fabricated to support interdigitated arrays of electrodes that have been designed to provide amplification of the electrical signal desired to analyze analytes that may be present at low concentration. COPYRIGHT: (C)2011,JPO&INPIT

    Abstract translation: 要解决的问题：提供一种新的基于锇的电化学物种，用于使用电化学氧化/还原标记（也称为电子转移剂或电化学介体标记）的免疫学技术检测各种各样的分析物。 解决方案：提供了可用于免疫测定的新的基于锇的电化学物质。 锇物质可与用于检测相关分析物的特异性结合配体结合，并且还可以含有使用各种键合基团与特异性结合配体键合的1,2或4个锇中心。 还提供了可用于锇基电化学物种的测试传感器和支持电极结构的诊断套件。 测试传感器可以被制造成支持已经被设计为提供期望分析可能以低浓度存在的分析物的电信号的放大的交叉指示的电极阵列。 版权所有（C）2011，JPO＆INPIT

    SYSTEM AND METHOD FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN A SAMPLE FLUID
    4.
    发明申请
    SYSTEM AND METHOD FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN A SAMPLE FLUID 审中-公开
    用于确定样品液中分析物浓度的系统和方法

    公开(公告)号：WO2011079938A3

    公开(公告)日：2011-08-25

    申请号：PCT/EP2010007931

    申请日：2010-12-23

    Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE

    Inventor： DIEBOLD ERIC R ,  BUCK HARVEY B JR ,  BEATY TERRY A

    IPC: G01N33/49

    CPC classification number: G01N27/3274 ,  G01N33/49

    Abstract: The present disclosure relates to various methods for measuring the amount of an analyte present in a biological fluid using an electrochemical testing process. Various embodiments are disclosed, including the use of AC test signals and the performance of tests having a Total Test Time within about 2.0 seconds or less, and/or having a clinically low Total System Error.

    Abstract translation: 本公开涉及使用电化学测试方法测量存在于生物流体中的分析物的量的各种方法。 公开了各种实施例，包括使用AC测试信号和在大约2.0秒或更短时间内具有总测试时间的测试和/或具有临床上低的总系统误差的测试。

    STATUS REPORTING OF A STRUCTURED COLLECTION PROCEDURE
    6.
    发明申请
    STATUS REPORTING OF A STRUCTURED COLLECTION PROCEDURE 审中-公开
    结构性收集程序的状态报告

    公开(公告)号：WO2011157372A3

    公开(公告)日：2012-03-08

    申请号：PCT/EP2011002809

    申请日：2011-06-08

    Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE

    Inventor： SONI ABHISHEK S ,  GALLEY PAUL J ,  GREENBURG ALAN ,  BOUSAMRA STEVEN ,  WEINERT STEFAN ,  DIEBOLD ERIC R

    IPC: G06F19/00 ,  A61B5/145

    CPC classification number: G06F19/3456 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/4839 ,  A61B5/7275 ,  G06F19/3418 ,  G06F19/3468 ,  G06F19/3475 ,  G06F19/3481 ,  G06Q50/24 ,  G16H10/20 ,  G16H10/60 ,  G16H15/00

    Abstract: Embodiments related to a system and method managing the implementation, execution, data collection, data analysis and status reporting of a structured collection procedure running on a portable, hand-held collection device are disclosed. The collection device performing the structured collection procedure has program instructions that when executed by a processor cause the processor to initiate automatically a schedule of events of the structured collection procedure upon one or more entry criteria being met at some unknown time, store in memory patient data collected in accordance to the schedule of events, end automatically the structured collection procedure upon one or more exit criteria being met at some unknown time. Status reporting can be provided throughout the execution of the collection procedure.

    Abstract translation: 公开了涉及在便携式手持收集装置上运行的结构化收集过程的实现，执行，数据收集，数据分析和状态报告的系统和方法的实施例。 执行结构化收集过程的收集装置具有当处理器执行时使得处理器在某个未知时间满足一个或多个入口标准时自动启动结构化收集过程的事件调度的程序指令，存储在存储器患者数据中 根据事件进度收集，在一些未知时间满足一个或多个退出条件时自动结束结算收集程序。 可以在整个执行收集过程中提供状态报告。

    SYSTEMS AND METHODS FOR MULTIPLE ANALYTE ANALYSIS
    8.
    发明专利
    SYSTEMS AND METHODS FOR MULTIPLE ANALYTE ANALYSIS 未知

    公开(公告)号：CA2886112A1

    公开(公告)日：2014-05-08

    申请号：CA2886112

    申请日：2013-10-31

    Applicant: HOFFMANN LA ROCHE

    Inventor： DIEBOLD ERIC R ,  GERBER MARTIN T

    IPC: G01N33/66 ,  A61B5/00 ,  G01N33/487 ,  G01N33/49

    Abstract: Systems and methods for multiple analyte analysis are provided. In one embodiment, a method includes determining concentrations of first and second analytes in a sample. The first and second analytes may be, for example, glucose and hydroxybutyrate. In this form, an indication related to the measured concentration of hydroxybutyrate is provided in response to determining that the concentration of hydroxybutyrate is above a predetermined value. In a further aspect of this form, a quantitative indication representative of the measured glucose concentration is automatically provided regardless of the value of the measured glucose concentration. In another embodiment, a system includes a meter configured to interact with a test element to assess first and second analytes in a sample. Further embodiments, forms, objects, features, advantages, aspects, and benefits shall become apparent from the description and drawings.

    METHODS FOR MANUFACTURING A DUAL BIOSENSOR TEST STRIP
    9.
    发明专利
    METHODS FOR MANUFACTURING A DUAL BIOSENSOR TEST STRIP 未知

    公开(公告)号：CA2801946A1

    公开(公告)日：2012-01-05

    申请号：CA2801946

    申请日：2011-06-30

    Applicant: HOFFMANN LA ROCHE

    Inventor： RIGGLES RANDALL K ,  DIEBOLD ERIC R ,  JOSEPH ABNER DAVID ,  BEATY TERRY A

    IPC: G01N33/487

    Abstract: Some embodiments of the invention include a 2 -up manufacturing technique for producing test strips (100) to reduce costs, reduce waste, and increase output. Other techniques relating to the 2 -up technique, such as simultaneously manufacturing test strips (100) arranged in multiple columns, are also disclosed. Yet other techniques include cutting through the upper (110) and lower substrates (130) to form an overhang of either the upper (110) or the lower substrate (130). Other embodiments include a dual -use biosensor in which a user can apply a sample of bodily fluid to both test strips simultaneously.

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