公开(公告)号：WO2006119914A3

公开(公告)日：2007-02-01

申请号：PCT/EP2006004179

申请日：2006-05-04

Applicant: HOFFMANN LA ROCHE ,  ROCHE DIAGNOSTICS GMBH ,  FERRARI STEFANO ,  QUARDER ORTRUD ,  STEPHAN PETER

Inventor： FERRARI STEFANO ,  QUARDER ORTRUD ,  STEPHAN PETER

IPC: A61B5/00

CPC classification number: A61B5/14532 ,  A61B5/14528 ,  A61B5/1473

Abstract: The invention relates to a method and a device for determining the glucose concentration in tissue liquid (40). Said method and device are used for detecting (sensor 12) measured values for glucose and an endogenous reference substance in a sample liquid (42) obtained by means of microdialysis, microperfusion, or ultrafiltration (probe 10) and correcting the glucose value in accordance with the measured value for the reference substance. The invention is characterized in that the glucose recovery rate is determined from a non-linear correlation with the recovery rate for the ionic reference substance while the measured value for glucose is corrected therewith. Furthermore, the lactate concentration and/or pyruvate concentration is/are used as (an) additional reference substance(s) in the sample liquid to make further corrections.

Abstract translation: 本发明涉及一种用于确定在组织液从而在通过微透析微灌或超滤（探针10）中得到的葡萄糖浓度（40），样品液体的方法和装置，（42）的记录测定的葡萄糖和用于内源对照品值（传感器 12）根据所述测量值中的葡萄糖值的参考物质校正。 这里提出，用于从与回收率为离子对照品被确定并且该葡萄糖测量值的非线性关系葡萄糖的回收率与它纠正，并且还作为在用于进一步校正的样本液体中的另外的参考物质的乳酸和/或丙酮酸的浓度 被使用。

公开(公告)号：CA2607396A1

公开(公告)日：2006-11-16

申请号：CA2607396

申请日：2006-05-04

Applicant: HOFFMANN LA ROCHE

Inventor： QUARDER ORTRUD ,  FERRARI STEFANO ,  STEPHAN PETER

IPC: A61B5/00

Abstract: The invention relates to a method and a device for determining the glucose concentration in tissue liquid (40). Said method and device are used for detecting (sensor 12) measured values for glucose and an endogenous referenc e substance in a sample liquid (42) obtained by means of microdialysis, microperfusion, or ultrafiltration (probe 10) and correcting the glucose val ue in accordance with the measured value for the reference substance. The invention is characterized in that the glucose recovery rate is determined from a non-linear correlation with the recovery rate for the ionic reference substance while the measured value for glucose is corrected therewith. Furthermore, the lactate concentration and/or pyruvate concentration is/are used as (an) additional reference substance(s) in the sample liquid to make further corrections.