公开(公告)号：WO2006119914A3

公开(公告)日：2007-02-01

申请号：PCT/EP2006004179

申请日：2006-05-04

Applicant: HOFFMANN LA ROCHE ,  ROCHE DIAGNOSTICS GMBH ,  FERRARI STEFANO ,  QUARDER ORTRUD ,  STEPHAN PETER

Inventor： FERRARI STEFANO ,  QUARDER ORTRUD ,  STEPHAN PETER

IPC: A61B5/00

CPC classification number: A61B5/14532 ,  A61B5/14528 ,  A61B5/1473

Abstract: The invention relates to a method and a device for determining the glucose concentration in tissue liquid (40). Said method and device are used for detecting (sensor 12) measured values for glucose and an endogenous reference substance in a sample liquid (42) obtained by means of microdialysis, microperfusion, or ultrafiltration (probe 10) and correcting the glucose value in accordance with the measured value for the reference substance. The invention is characterized in that the glucose recovery rate is determined from a non-linear correlation with the recovery rate for the ionic reference substance while the measured value for glucose is corrected therewith. Furthermore, the lactate concentration and/or pyruvate concentration is/are used as (an) additional reference substance(s) in the sample liquid to make further corrections.

Abstract translation: 本发明涉及一种用于确定在组织液从而在通过微透析微灌或超滤（探针10）中得到的葡萄糖浓度（40），样品液体的方法和装置，（42）的记录测定的葡萄糖和用于内源对照品值（传感器 12）根据所述测量值中的葡萄糖值的参考物质校正。 这里提出，用于从与回收率为离子对照品被确定并且该葡萄糖测量值的非线性关系葡萄糖的回收率与它纠正，并且还作为在用于进一步校正的样本液体中的另外的参考物质的乳酸和/或丙酮酸的浓度 被使用。

公开(公告)号：WO2006092309A8

公开(公告)日：2007-11-22

申请号：PCT/EP2006001922

申请日：2006-03-02

Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE ,  DECK FRANK ,  QUARDER ORTRUD ,  WEISS THOMAS ,  HOERAUF CHRISTIAN ,  KISTNER MICHAEL ,  KONYA AHMET ,  HARTTIG HERBERT ,  BAADER FELIX ,  LIST HANS ,  EBERT KARL-PETER

Inventor： DECK FRANK ,  QUARDER ORTRUD ,  WEISS THOMAS ,  HOERAUF CHRISTIAN ,  KISTNER MICHAEL ,  KONYA AHMET ,  HARTTIG HERBERT ,  BAADER FELIX ,  LIST HANS ,  EBERT KARL-PETER

IPC: A61B5/151

CPC classification number: A61B5/15148 ,  A61B5/150022 ,  A61B5/15019 ,  A61B5/150198 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/150832 ,  A61B5/150916 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15128 ,  A61B5/1519 ,  A61B5/15194 ,  A61B5/15196

Abstract: The invention relates to a piercing system for removing bodily fluid from the skin of a human or animal. Said system comprises a disposable piercing unit (1), which contains a needle element (6) for puncturing the skin, a piercing device (2), which encompasses a piercing drive (4), said drive propelling a piercing displacement of the piercing unit (1), which is coupled to the piercing drive (4) by means of a coupling mechanism (3), a predefined value of the piercing depth being guaranteed using a piercing depth reference element (10), which comprises a skin contact surface (11) and the predefined value of the piercing depth being determined by the distance in the piercing direction between the skin contact surface (11) and the position of the needle tip at the inversion point of the piercing displacement. The piercing depth reference element (10) is connected to the needle element (6) and coupled to the drive in such a way that it is displaced together with the needle element (1) during at least one part of the propulsion phase and has a defined longitudinal position in the piercing direction in relation to the needle element (6), at least at the inverse point of the piercing displacement.

Abstract translation: 用于收集体液从人或动物的皮肤上，用一次性采血部的柳叶刀切开系统（1）具有针构件（6），用于刺穿皮肤，穿刺装置（2），其包括穿刺驱动器（4），由 通过联接机构的装置连接到所述切缝驱动件的穿刺单元（1）的穿刺移动（3）（4）耦合，被驱动，由此，穿刺深度的由穿刺深度参考元件的装置的预定值（10）得到保证，其具有皮肤接触面（11）， 和穿刺深度的预定值.The通过在皮肤接触表面（11），并且在刺入运动穿刺深度参考元件的反转点的针尖（10）被连接在与所述针元件（6）这样的方式以及与所述驱动器的位置之间的穿刺方向的距离来确定， 它前进阶段的至少一部分过程中移动，与所述针构件（1）和至少一起 S具有相对于在刺穿移动的反转点的针构件（6）穿刺方向在限定的纵向位置。

公开(公告)号：WO2012092954A3

公开(公告)日：2012-10-18

申请号：PCT/EP2011006500

申请日：2011-12-22

Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE ,  STAIB ARNULF ,  QUARDER ORTRUD ,  WERNER GERHARD

Inventor： STAIB ARNULF ,  QUARDER ORTRUD ,  WERNER GERHARD

IPC: G09B23/00

CPC classification number: G06F19/70 ,  G09B23/28

Abstract: The invention relates to a method for evaluating a set of measurement data from an oral glucose tolerance test, wherein the set of measurement data contains a sequence of measurement data of the glucose concentration and, in addition, at least one sequence of measured values of a further analyte concentration. Provision is made according to the invention that, from the sequence of measured values of the glucose concentration and from in each case one of several predefined glucose sample profiles, in each case a value of a similarity measure is calculated that quantifies the similarity between the time profile of the sequence of measured values of the glucose concentration and the relevant glucose sample profile, and, from the sequence of measured values of the further analyte concentration and from several predefined analyte sample profiles, in each case a value of a further similarity measure is calculated that quantifies the similarity between the profile of the sequence of measured values of the further analyte concentration and the relevant analyte sample profile, the set of data is characterized, in a vector space having coordinate axes formed from the similarity measures, by a point whose coordinates contain the calculated values of the similarity measures, and the position of this point in relation to reference points that each represent a defined state of health is evaluated, in order to calculate a parameter that indicates the state of the glucose metabolism of the patient.

Abstract translation: 本发明涉及一种方法，用于评估一组口服葡萄糖耐受性测试的测量数据，其中，所述组测量数据包括中的葡萄糖浓度的测量数据的序列，和另一种分析物的测定值的附加的至少一种序列。 根据规定，在每种情况下的相似性度量的值是从葡萄糖浓度的测量值的序列来计算，并且在每种情况下，其量化的葡萄糖浓度和相应的葡萄糖模式历史的测量值的序列的时间进程之间的相似性几个预定葡萄糖样本的演变的一项的发明， 进一步的相似性中的一个值被从其他的分析物浓度的测量值的序列和多个预定的分析物样品的演变的量化其它分析物的浓度和相关的分析物模式历史的测量值的序列的形状之间的相似度计算，在矢量空间中的数据， 具有坐标由相似度措施形成的轴，其特征在于一个点的坐标包含的相似性度量的计算值，这点相对于的位置的基准点，每封 INEN定义健康代表，进行评估，以计算指示患者的葡萄糖代谢的状态的参数。

公开(公告)号：WO2006092309A3

公开(公告)日：2006-12-21

申请号：PCT/EP2006001922

申请日：2006-03-02

Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE ,  DECK FRANK ,  QUARDER ORTRUD ,  WEISS THOMAS ,  HOERAUF CHRISTIAN ,  KISTNER MICHAEL ,  KONYA AHMET ,  HARTTIG HERBERT ,  BAADER FELIX ,  LIST HANS ,  EBERT KARL-PETER

Inventor： DECK FRANK ,  QUARDER ORTRUD ,  WEISS THOMAS ,  HOERAUF CHRISTIAN ,  KISTNER MICHAEL ,  KONYA AHMET ,  HARTTIG HERBERT ,  BAADER FELIX ,  LIST HANS ,  EBERT KARL-PETER

IPC: A61B5/151

CPC classification number: A61B5/15148 ,  A61B5/150022 ,  A61B5/15019 ,  A61B5/150198 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/150832 ,  A61B5/150916 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15128 ,  A61B5/1519 ,  A61B5/15194 ,  A61B5/15196

Abstract: The invention relates to a piercing system for removing bodily fluid from the skin of a human or animal. Said system comprises a disposable piercing unit (1), which contains a needle element (6) for puncturing the skin, a piercing device (2), which encompasses a piercing drive (4), said drive propelling a piercing displacement of the piercing unit (1), which is coupled to the piercing drive (4) by means of a coupling mechanism (3), a predefined value of the piercing depth being guaranteed using a piercing depth reference element (10), which comprises a skin contact surface (11) and the predefined value of the piercing depth being determined by the distance in the piercing direction between the skin contact surface (11) and the position of the needle tip at the inversion point of the piercing displacement. The piercing depth reference element (10) is connected to the needle element (6) and coupled to the drive in such a way that it is displaced together with the needle element (1) during at least one part of the propulsion phase and has a defined longitudinal position in the piercing direction in relation to the needle element (6), at least at the inverse point of the piercing displacement.

Abstract translation: 用于收集体液从人或动物的皮肤上，用一次性采血部的柳叶刀切开系统（1）具有针构件（6），用于刺穿皮肤，穿刺装置（2），其包括穿刺驱动器（4），由 通过联接机构的装置连接到所述切缝驱动件的穿刺单元（1）的穿刺移动（3）（4）耦合，被驱动，由此，穿刺深度的由穿刺深度参考元件的装置的预定值（10）得到保证，其具有皮肤接触面（11）， 和穿刺深度的预定值.The通过在皮肤接触表面（11），并且在刺入运动穿刺深度参考元件的反转点的针尖（10）被连接在与所述针元件（6）这样的方式以及与所述驱动器的位置之间的穿刺方向的距离来确定， 在推进阶段的至少一部分期间它至少与针元件（1）一起移动 s在刺穿运动的反向点处具有相对于针元件（6）在穿刺方向上限定的纵向位置。

公开(公告)号：DK2661741T3

公开(公告)日：2019-06-24

申请号：DK11808833

申请日：2011-12-22

Applicant: HOFFMANN LA ROCHE

Inventor： STAIB ARNULF ,  QUARDER ORTRUD ,  WERNER GERHARD

IPC: G09B23/00

公开(公告)号：AU2009291267A1

公开(公告)日：2010-03-18

申请号：AU2009291267

申请日：2009-05-27

Applicant: HOFFMANN LA ROCHE

Inventor： QUARDER ORTRUD ,  MISCHLER REINHOLD ,  RIEGER EWALD ,  STAIB ARNULF ,  GILLEN RALPH ,  KAMECKE ULRIKE

IPC: A61B5/00

Abstract: The electrode system comprises a counter electrode (2) with an electric conductor, a working electrode (1) with an electric conductor on which an enzyme layer is arranged that consists of immobilized enzyme molecules for catalytic transformation of analytes, and a diffusion brake, which slows down the diffusion of the analytes from body fluid surrounding the electrode system, to enzyme molecules. The enzyme layer is formed in the form of several fields that are arranged to each other on the conductor of the working electrode in an interval. The electrode system comprises a counter electrode (2) with an electric conductor, a working electrode (1) with an electric conductor on which an enzyme layer is arranged that consists of immobilized enzyme molecules for catalytic transformation of analytes, and a diffusion brake, which slows down the diffusion of the analytes from body fluid surrounding the electrode system, to enzyme molecules. The enzyme layer is formed in the form of several fields that are arranged to each other on the conductor of the working electrode in an interval. The two of the fields of the enzyme layer of 5 mm are removed from one another. An interval between adjoining fields of the enzyme layer is 0.3 mm. The fields of the enzyme layer of 2 mm extend itself in two directions vertical to each other. The diffusion brake is formed as a layer covering the enzyme layer. The enzyme cooperates with a catalytic redox mediator that reduces or prevents an oxygen dependence of the catalytic conversion of the analytes. The catalytic redox mediator transfers hydrogen peroxide and causes a direct electron transfer. The electrode system is bent without breaking around 90[deg] . The working electrode comprises a spacer that is arranged by the conductor over the enzyme layer. The spacer covers the working electrode and the counter electrode as solid layer. The electric conductors of the working electrode and the counter electrode are arranged on a substrate (4). The conductor of the working electrode has narrow positions between the enzyme layer fields and the conductor of the counter electrode has contour following the progress of the conductor of the working electrode. An independent claim is included for a sensor with electrode system.

公开(公告)号：AT491391T

公开(公告)日：2011-01-15

申请号：AT06015187

申请日：2006-07-21

Applicant: HOFFMANN LA ROCHE

Inventor： HOENES JOACHIM ,  ZIMMER VOLKER ,  VOELKEL DIRK ,  HAAR HANS-PETER ,  QUARDER ORTRUD ,  KUHR HANS-JUERGEN ,  HARTTIG HERBERT

IPC: A61B5/151

Abstract: The recovery device has a lancet (1), which has a lancet body (2) with two tips (3). The tips have different lengths. The device has a selection unit for a tip, so that pricking is carried out with definite penetrating depth in a body part, where the body part is arranged opposite to the device, depending on the length of the selected tip. The pricking is not done with the non-selected tip. The two tips are arranged in different directions at the lancet body, in a star forming linear manner. The device has a drive unit for moving the lancet. An independent claim is also included for a lancet, which has a lancet body with two tips, having different lengths.

公开(公告)号：CA2607396A1

公开(公告)日：2006-11-16

申请号：CA2607396

申请日：2006-05-04

Applicant: HOFFMANN LA ROCHE

Inventor： QUARDER ORTRUD ,  FERRARI STEFANO ,  STEPHAN PETER

IPC: A61B5/00

Abstract: The invention relates to a method and a device for determining the glucose concentration in tissue liquid (40). Said method and device are used for detecting (sensor 12) measured values for glucose and an endogenous referenc e substance in a sample liquid (42) obtained by means of microdialysis, microperfusion, or ultrafiltration (probe 10) and correcting the glucose val ue in accordance with the measured value for the reference substance. The invention is characterized in that the glucose recovery rate is determined from a non-linear correlation with the recovery rate for the ionic reference substance while the measured value for glucose is corrected therewith. Furthermore, the lactate concentration and/or pyruvate concentration is/are used as (an) additional reference substance(s) in the sample liquid to make further corrections.

公开(公告)号：CA2598770A1

公开(公告)日：2006-09-08

申请号：CA2598770

申请日：2006-03-02

Applicant: HOFFMANN LA ROCHE

Inventor： BAADER FELIX ,  QUARDER ORTRUD ,  WEISS THOMAS ,  HARTTIG HERBERT ,  EBERT KARL-PETER ,  DECK FRANK ,  LIST HANS ,  KISTNER MICHAEL ,  HOERAUF CHRISTIAN ,  KONYA AHMET

IPC: A61B5/151

Abstract: The invention relates to a piercing system for removing bodily fluid from th e skin of a human or animal. Said system comprises a disposable piercing unit (1), which contains a needle element (6) for puncturing the skin, a piercing device (2), which encompasses a piercing drive (4), said drive propelling a piercing displacement of the piercing unit (1), which is coupled to the piercing drive (4) by means of a coupling mechanism (3), a predefined value of the piercing depth being guaranteed using a piercing depth reference element (10), which comprises a skin contact surface (11) and the predefined value o f the piercing depth being determined by the distance in the piercing directio n between the skin contact surface (11) and the position of the needle tip at the inversion point of the piercing displacement. The piercing depth referen ce element (10) is connected to the needle element (6) and coupled to the drive in such a way that it is displaced together with the needle element (1) duri ng at least one part of the propulsion phase and has a defined longitudinal position in the piercing direction in relation to the needle element (6), at least at the inverse point of the piercing displacement.

公开(公告)号：ES2424879T3

公开(公告)日：2013-10-09

申请号：ES09812678

申请日：2009-05-27

Applicant: HOFFMANN LA ROCHE

Inventor： QUARDER ORTRUD ,  MISCHLER REINHOLD ,  RIEGER EWALD ,  STAIB ARNULF ,  GILLEN RALPH ,  KAMECKE ULRIKE

IPC: A61B5/145 ,  A61B5/1486

Abstract: Sistema de electrodos para medir la concentración de un analito bajo condiciones in vivo, que comprendeun contraelectrodo (2) que presenta un conductor eléctrico (2a), un electrodo de trabajo (1) que presenta unconductor eléctrico (1a) sobre el que se aplica una capa de enzima (5) que contiene moléculas inmovilizadas deenzima para la conversión catalítica del analito, y una barrera de difusión (8) que enlentece la difusión del analitodesde el líquido corporal circundante al sistema de electrodos hasta las moléculas de enzima, caracterizado porquela capa de enzima (5) se ha diseñado en forma de múltiples campos que se disponen sobre el conductor (1a) delelectrodo de trabajo (1) separados por cierta distancia